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RAT:RNF4
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Rnf4 (synonyms: Snurf) | |
| Protein Name(s) | E3 ubiquitin-protein ligase RNF4
RING finger protein 4 Small nuclear ring finger protein Protein SNURF | |
| External Links | ||
| UniProt | O88846 | |
| EMBL | AF022081 AY050655 BC062024 | |
| RefSeq | NP_062055.1 XP_008768493.1 XP_008768494.1 XP_008768495.1 | |
| UniGene | Rn.30015 | |
| PDB | 3NG2 4AP4 | |
| PDBsum | 3NG2 4AP4 | |
| ProteinModelPortal | O88846 | |
| SMR | O88846 | |
| BioGrid | 247945 | |
| IntAct | O88846 | |
| STRING | 10116.ENSRNOP00000019555 | |
| PhosphoSite | O88846 | |
| PRIDE | O88846 | |
| GeneID | 29274 | |
| KEGG | rno:29274 | |
| CTD | 6047 | |
| RGD | 3583 | |
| eggNOG | NOG327779 | |
| HOGENOM | HOG000059548 | |
| HOVERGEN | HBG018577 | |
| InParanoid | O88846 | |
| OrthoDB | EOG7SN8F1 | |
| PhylomeDB | O88846 | |
| TreeFam | TF328387 | |
| UniPathway | UPA00143 | |
| EvolutionaryTrace | O88846 | |
| NextBio | 608631 | |
| PRO | PR:O88846 | |
| Proteomes | UP000002494 | |
| Genevestigator | O88846 | |
| GO | GO:0005737 GO:0005654 GO:0005634 GO:0016605 GO:0050681 GO:0003677 GO:0030331 GO:0016874 GO:0031491 GO:0033142 GO:0032184 GO:0017025 GO:0004842 GO:0008270 GO:0071480 GO:0072711 GO:0060548 GO:0045944 GO:0045893 GO:0043161 GO:0051865 GO:0070979 GO:0070936 GO:0085020 GO:0070534 GO:0016567 GO:0090234 GO:0090169 GO:0046685 GO:0006351 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR001841 IPR013083 IPR017907 | |
| Pfam | PF13639 | |
| SMART | SM00184 | |
| PROSITE | PS00518 PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 4a, 4b, 4c. |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 2 and Figure 8. |
complete | |||||
|
involved_in |
GO:0090234 |
regulation of kinetochore assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090169 |
regulation of spindle assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0085020 |
protein K6-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070979 |
protein K11-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070534 |
protein K63-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051865 |
protein autoubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046685 |
response to arsenic-containing substance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032184 |
SUMO polymer binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032184 |
SUMO polymer binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031491 |
nucleosome binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0016605 |
PML body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072711 |
cellular response to hydroxyurea |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071480 |
cellular response to gamma radiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071394 |
cellular response to testosterone stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071243 |
cellular response to arsenic-containing substance |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060548 |
negative regulation of cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051865 |
protein autoubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050681 |
androgen receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:2147 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044752 |
response to human chorionic gonadotropin |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033142 |
progesterone receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:731081 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032355 |
response to estradiol |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032184 |
SUMO polymer binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031624 |
ubiquitin conjugating enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:1317341 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030331 |
estrogen receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:10551 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017025 |
TBP-class protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008584 |
male gonad development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1201691 |
P |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0016605 |
PML body |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000548419 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1201691 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016605 |
PML body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Moilanen, AM et al. (1998) Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol. Cell. Biol. 18 5128-39 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Häkli, M et al. (2001) The RING finger protein SNURF is a bifunctional protein possessing DNA binding activity. J. Biol. Chem. 276 23653-60 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Tatham, MH et al. (2008) RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat. Cell Biol. 10 538-46 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Häkli, M et al. (2004) Transcriptional coregulator SNURF (RNF4) possesses ubiquitin E3 ligase activity. FEBS Lett. 560 56-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Geoffroy, MC et al. (2010) Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. Mol. Biol. Cell 21 4227-39 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Yin, Y et al. (2012) SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev. 26 1196-208 PubMed GONUTS page
- ↑ Adams, V et al. (2001) Differentially expressed genes in L6 rat skeletal muscle myoblasts after incubation with inflammatory cytokines. Cytokine 13 342-8 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Plechanovová, A et al. (2011) Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat. Struct. Mol. Biol. 18 1052-9 PubMed GONUTS page
- ↑ 9.0 9.1 Hirvonen-Santti, SJ et al. (2004) Small nuclear RING finger protein expression during gonad development: regulation by gonadotropins and estrogen in the postnatal ovary. Endocrinology 145 2433-44 PubMed GONUTS page
- ↑ 10.0 10.1 Yan, W et al. (2002) Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation. Mech. Dev. 118 247-53 PubMed GONUTS page
- ↑ Chakraborty, C et al. (1995) Plasma clearance, tissue uptake and expression of pituitary peptide 23/pancreatitis-associated protein in the rat. J. Endocrinol. 145 461-9 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
- GO:0071394 ! cellular response to testosterone stimulus
- GO:0071345 ! cellular response to cytokine stimulus
- GO:0071480 ! cellular response to gamma radiation
- GO:0072711 ! cellular response to hydroxyurea
- GO:0071243 ! cellular response to arsenic-containing substance
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
g
m
n
p
- GO:0016605 ! PML body
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0051865 ! protein autoubiquitination
- GO:0042803 ! protein homodimerization activity
- GO:0085020 ! protein K6-linked ubiquitination
- GO:0070979 ! protein K11-linked ubiquitination
- GO:0070936 ! protein K48-linked ubiquitination
- GO:0070534 ! protein K63-linked ubiquitination
- GO:0016567 ! protein ubiquitination
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t
u
