RAT:RGS2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Rgs2
Protein Name(s)	Regulator of G-protein signaling 2 RGS2
External Links
UniProt	Q9JHX0
EMBL	AF279918 AF321837 AY043246 BC061969 AJ318489
RefSeq	NP_445905.1
UniGene	Rn.1892
ProteinModelPortal	Q9JHX0
SMR	Q9JHX0
STRING	10116.ENSRNOP00000005156
Ensembl	ENSRNOT00000005156
GeneID	84583
KEGG	rno:84583
UCSC	RGD:621665
CTD	5997
RGD	621665
eggNOG	NOG252352
GeneTree	ENSGT00760000118903
HOGENOM	HOG000233512
HOVERGEN	HBG013233
InParanoid	Q9JHX0
KO	K18154
OMA	QQAFIKP
OrthoDB	EOG7VHSZ5
PhylomeDB	Q9JHX0
TreeFam	TF315837
Reactome	REACT_263374
NextBio	617163
PRO	PR:Q9JHX0
Proteomes	UP000002494
Genevestigator	Q9JHX0
GO	GO:0005737 GO:0009898 GO:0005829 GO:0043005 GO:0005730 GO:0005886 GO:0048487 GO:0005096 GO:0050873 GO:0007049 GO:0043951 GO:0010614 GO:0045744 GO:0043407 GO:0010519 GO:0060452 GO:0043547 GO:0031116 GO:0071877 GO:0006417 GO:0055119 GO:0060087 GO:0007283 GO:0038032
Gene3D	1.10.196.10
InterPro	IPR016137 IPR024066
Pfam	PF00615
PRINTS	PR01301
SMART	SM00315
SUPFAM	SSF48097
PROSITE	PS50132

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0071878	negative regulation of adrenergic receptor signaling pathway	PMID:20362664^[1]	ECO:0000315			P	Figure 6: RGS2 overexpression leads to a reduction in cAMP accumulation in rat neonatal ventricular cardiomyocytes.	complete
	GO:0071875	adrenergic receptor signaling pathway	PMID:20362664^[1]	ECO:0000314			P	Figure 1: Activation of B-AR induces RGS expression in cultured cardiomyocytes	complete
	GO:0010614	negative regulation of cardiac muscle hypertrophy	PMID:20362664^[1]	ECO:0000315			P	Figure 4+5: RGS2 overexpression attenuates ISO-induced (B-AR) cardiomyoctye hypertrophy and hypertrophic gene expression.	complete
	GO:0043405	regulation of MAP kinase activity	PMID:20362664^[1]	ECO:0000314			P	Figurre 7: Immunoblots show that RGS2 decreases ERK phosphorylation (a) and increases JNK phosphorylation (B) - part of MAP kinase pathway.	complete
	GO:0051896	regulation of protein kinase B signaling cascade	PMID:20362664^[1]	ECO:0000314			P	Figure 8: Immunoblots show thatRGS2 limits signalling leading to Akt phosphorylation in cardiomyocytes	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41220	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41220	C	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41220	F	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41220	P	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:21291891^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1900924	negative regulation of glycine import across plasma membrane	PMID:21798518^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	PMID:16380388^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060135	maternal process involved in female pregnancy	PMID:12712095^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	PMID:16820281^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:628596	F	Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	PMID:21798518^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	PMID:11968023^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:28736108^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:16820281^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030728	ovulation	PMID:11058559^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:24576550^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:16820281^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:11906535^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15946253^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	PMID:26321241^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0140194	negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0060452	positive regulation of cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0060087	relaxation of vascular smooth muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0055119	relaxation of cardiac muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0050873	brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0043951	negative regulation of cAMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0010614	negative regulation of cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
involved_in	GO:0010519	negative regulation of phospholipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	C	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08849 ensembl:ENSMUSP00000115558	C	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	C	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	F	Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R939 ensembl:ENSP00000235382	C	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034947	F	Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034947	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0343	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Nunn, C et al. (2010) RGS2 inhibits beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Cell. Signal. 22 1231-9 PubMed GONUTS page
↑ Chakir, K et al. (2011) RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J. Mol. Cell. Cardiol. 50 1000-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Ji, M et al. (2011) RGS2 and RGS4 modulate melatonin-induced potentiation of glycine currents in rat retinal ganglion cells. Brain Res. 1411 1-8 PubMed GONUTS page
↑ Zhang, W et al. (2006) Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. J. Biol. Chem. 281 5811-20 PubMed GONUTS page
↑ Suarez, VR et al. (2003) Expression of regulator of G protein signaling-2 in rat myometrium during pregnancy and parturition. Am. J. Obstet. Gynecol. 188 973-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Heo, K et al. (2006) RGS2 promotes formation of neurites by stimulating microtubule polymerization. Cell. Signal. 18 2182-92 PubMed GONUTS page
↑ Thirunavukkarasu, K et al. (2002) Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. J. Cell. Biochem. 85 837-50 PubMed GONUTS page
↑ Luessen, DJ et al. (2017) Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex. Brain Res. 1672 106-112 PubMed GONUTS page
↑ Ujioka, T et al. (2000) Expression of regulator of G-protein signaling protein-2 gene in the rat ovary at the time of ovulation. Biol. Reprod. 63 1513-7 PubMed GONUTS page
↑ Chidiac, P et al. (2014) The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes. Cell. Signal. 26 1226-34 PubMed GONUTS page
↑ Ingi, T & Aoki, Y (2002) Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain. Eur. J. Neurosci. 15 929-36 PubMed GONUTS page
↑ Kveberg, L et al. (2005) Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D. Immunology 115 358-65 PubMed GONUTS page
↑ Sun, H et al. (2015) The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience 307 253-61 PubMed GONUTS page

[PMID:20362664-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Nunn, C et al. (2010) RGS2 inhibits beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Cell. Signal. 22 1231-9 PubMed GONUTS page

[PMID:21291891-2] Chakir, K et al. (2011) RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J. Mol. Cell. Cardiol. 50 1000-7 PubMed GONUTS page

[PMID:21798518-3] 3.0 ^3.1 Ji, M et al. (2011) RGS2 and RGS4 modulate melatonin-induced potentiation of glycine currents in rat retinal ganglion cells. Brain Res. 1411 1-8 PubMed GONUTS page

[PMID:16380388-4] Zhang, W et al. (2006) Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. J. Biol. Chem. 281 5811-20 PubMed GONUTS page

[PMID:12712095-5] Suarez, VR et al. (2003) Expression of regulator of G protein signaling-2 in rat myometrium during pregnancy and parturition. Am. J. Obstet. Gynecol. 188 973-7 PubMed GONUTS page

[PMID:16820281-6] 6.0 ^6.1 ^6.2 Heo, K et al. (2006) RGS2 promotes formation of neurites by stimulating microtubule polymerization. Cell. Signal. 18 2182-92 PubMed GONUTS page

[PMID:11968023-7] Thirunavukkarasu, K et al. (2002) Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. J. Cell. Biochem. 85 837-50 PubMed GONUTS page

[PMID:28736108-8] Luessen, DJ et al. (2017) Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex. Brain Res. 1672 106-112 PubMed GONUTS page

[PMID:11058559-9] Ujioka, T et al. (2000) Expression of regulator of G-protein signaling protein-2 gene in the rat ovary at the time of ovulation. Biol. Reprod. 63 1513-7 PubMed GONUTS page

[PMID:24576550-10] Chidiac, P et al. (2014) The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes. Cell. Signal. 26 1226-34 PubMed GONUTS page

[PMID:11906535-11] Ingi, T & Aoki, Y (2002) Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain. Eur. J. Neurosci. 15 929-36 PubMed GONUTS page

[PMID:15946253-12] Kveberg, L et al. (2005) Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D. Immunology 115 358-65 PubMed GONUTS page

[PMID:26321241-13] Sun, H et al. (2015) The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience 307 253-61 PubMed GONUTS page

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RAT:RGS2

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