GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

RAT:RB

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Rb1 (synonyms: Rb-1)
Protein Name(s) Retinoblastoma-associated protein

pRb Rb pp105

External Links
UniProt P33568
EMBL D25233
L07126
PIR S35544
RefSeq NP_058741.1
UniGene Rn.55115
BioGrid 246837
IntAct P33568
STRING 10116.ENSRNOP00000021752
PhosphoSite P33568
PaxDb P33568
PRIDE P33568
GeneID 24708
KEGG rno:24708
UCSC RGD:3540
CTD 5925
RGD 3540
eggNOG NOG296920
HOGENOM HOG000136539
HOVERGEN HBG008967
InParanoid P33568
KO K06618
OrthoDB EOG7P5T04
PhylomeDB P33568
TreeFam TF105568
NextBio 604187
PRO PR:P33568
Proteomes UP000002494
Genevestigator P33568
GO GO:0005634
GO:0016605
GO:0003677
GO:0019900
GO:0008134
GO:0007049
GO:0016568
GO:0097284
GO:0045445
GO:0043066
GO:0006469
GO:0051726
GO:0043550
GO:0006357
GO:0006351
Gene3D 1.10.472.10
InterPro IPR013763
IPR002720
IPR002719
IPR015030
IPR028309
IPR024599
PANTHER PTHR13742
Pfam PF11934
PF01858
PF01857
PF08934
SMART SM00385
SUPFAM SSF47954

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0120163

negative regulation of cold-induced thermogenesis

PMID:19417128[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13405

P

Seeded From UniProt

complete

colocalizes_with

GO:0008024

cyclin/CDK positive transcription elongation factor complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06400

C

Seeded From UniProt

complete

involved_in

GO:0045445

myoblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06400

P

Seeded From UniProt

complete

involved_in

GO:0043550

regulation of lipid kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06400

P

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06400

F

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06400

C

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06400

F

Seeded From UniProt

complete

involved_in

GO:0006469

negative regulation of protein kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06400

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06400

C

Seeded From UniProt

complete

involved_in

GO:1903944

negative regulation of hepatocyte apoptotic process

PMID:8649852[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:9697699[3]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:728892

F

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:15659706[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10725332[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015799
FB:FBgn0038390
MGI:MGI:97874
PANTHER:PTN000348425

P

Seeded From UniProt

complete

involved_in

GO:0048667

cell morphogenesis involved in neuron differentiation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97874
PANTHER:PTN000348429

P

Seeded From UniProt

complete

part_of

GO:0035189

Rb-E2F complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97874
PANTHER:PTN000348429
UniProtKB:P06400

C

Seeded From UniProt

complete

involved_in

GO:0031175

neuron projection development

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97874
PANTHER:PTN000348429

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97874
PANTHER:PTN000348429

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000348425
UniProtKB:Q9LKZ3

P

Seeded From UniProt

complete

involved_in

GO:0007346

regulation of mitotic cell cycle

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000348425
UniProtKB:P06400

P

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103300
MGI:MGI:105085
MGI:MGI:97874
PANTHER:PTN000348425

C

Seeded From UniProt

complete

colocalizes_with

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015799
MGI:MGI:103300
MGI:MGI:105085
MGI:MGI:97874
PANTHER:PTN000348425
RGD:3540
UniProtKB:P06400
UniProtKB:Q08999
UniProtKB:Q9LKZ3
WB:WBGene00003020

C

Seeded From UniProt

complete

enables

GO:0001102

RNA polymerase II activating transcription factor binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97874
PANTHER:PTN000348425

F

Seeded From UniProt

complete

enables

GO:0001012

RNA polymerase II regulatory region DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015799
PANTHER:PTN000348425

F

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015799
PANTHER:PTN000348425
RGD:3541

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002719
InterPro:IPR002720

C

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028309

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033057

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033057

F

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033057

P

Seeded From UniProt

complete

part_of

GO:0035189

Rb-E2F complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033057

C

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033057

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002719
InterPro:IPR002720
InterPro:IPR028309

P

Seeded From UniProt

complete

involved_in

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033057

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Mercader, J et al. (2009) Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice. Am. J. Physiol. Endocrinol. Metab. 297 E184-93 PubMed GONUTS page
  2. ↑ Fan, G et al. (1996) The retinoblastoma gene product inhibits TGF-beta1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells. Oncogene 12 1909-19 PubMed GONUTS page
  3. ↑ Woitach, JT et al. (1998) A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat. Genet. 19 371-4 PubMed GONUTS page
  4. ↑ Tan, KA et al. (2005) Androgen regulation of stage-dependent cyclin D2 expression in Sertoli cells suggests a role in modulating androgen action on spermatogenesis. Biol. Reprod. 72 1151-60 PubMed GONUTS page
  5. ↑ Gill, RM & Hamel, PA (2000) Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle. J. Cell Biol. 148 1187-201 PubMed GONUTS page
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=RAT:RB&oldid=5939758"