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RAT:PHB2
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Phb2 (ECO:0000250 with UniProtKB:Q99623) (synonyms: Bcap37 (ECO:0000312 with EMBL:AAH83705.1)) | |
| Protein Name(s) | Prohibitin-2
B-cell receptor-associated protein BAP37 BAP-37 | |
| External Links | ||
| UniProt | Q5XIH7 | |
| EMBL | BC083705 U75391 U75392 | |
| RefSeq | NP_001013053.1 | |
| UniGene | Rn.64535 | |
| ProteinModelPortal | Q5XIH7 | |
| BioGrid | 250411 | |
| IntAct | Q5XIH7 | |
| MINT | MINT-4594704 | |
| PhosphoSite | Q5XIH7 | |
| PaxDb | Q5XIH7 | |
| PRIDE | Q5XIH7 | |
| Ensembl | ENSRNOT00000017472 | |
| GeneID | 114766 | |
| KEGG | rno:114766 | |
| UCSC | RGD:620203 | |
| CTD | 11331 | |
| RGD | 620203 | |
| eggNOG | COG0330 | |
| GeneTree | ENSGT00550000075076 | |
| HOGENOM | HOG000205692 | |
| HOVERGEN | HBG004457 | |
| InParanoid | Q5XIH7 | |
| KO | K17081 | |
| OMA | NIQDSGF | |
| OrthoDB | EOG7V4B04 | |
| PhylomeDB | Q5XIH7 | |
| TreeFam | TF354230 | |
| NextBio | 618857 | |
| PRO | PR:Q5XIH7 | |
| Proteomes | UP000002494 | |
| Genevestigator | Q5XIH7 | |
| GO | GO:0070062 GO:0005743 GO:0016363 GO:0005634 GO:0043234 GO:0060749 GO:0060744 GO:0033147 GO:0033600 GO:0045892 GO:0060762 GO:0006351 | |
| InterPro | IPR001107 IPR000163 | |
| PANTHER | PTHR23222 | |
| Pfam | PF01145 | |
| PRINTS | PR00679 | |
| SMART | SM00244 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016363 |
nuclear matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0001230 |
mass spectrometry evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0001230 |
mass spectrometry evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0001230 |
mass spectrometry evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048786 |
presynaptic active zone |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048786 |
presynaptic active zone |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048786 |
presynaptic active zone |
ECO:0001230 |
mass spectrometry evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048786 |
presynaptic active zone |
ECO:0001230 |
mass spectrometry evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0001230 |
mass spectrometry evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071300 |
cellular response to retinoic acid |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009611 |
response to wounding |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060762 |
regulation of branching involved in mammary gland duct morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060749 |
mammary gland alveolus development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060744 |
mammary gland branching involved in thelarche |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033600 |
negative regulation of mammary gland epithelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033147 |
negative regulation of intracellular estrogen receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35129 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902808 |
positive regulation of cell cycle G1/S phase transition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0071944 |
cell periphery |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0033218 |
amide binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031536 |
positive regulation of exit from mitosis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016363 |
nuclear matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007062 |
sister chromatid cohesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007005 |
mitochondrion organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006606 |
protein import into nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99623 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kuramori, C et al. (2009) Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus. Biochem. Biophys. Res. Commun. 379 519-25 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Boyken, J et al. (2013) Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Neuron 78 285-97 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Dosemeci, A et al. (2007) Composition of the synaptic PSD-95 complex. Mol. Cell Proteomics 6 1749-60 PubMed GONUTS page
- ↑ 4.0 4.1 Zhou, TB et al. (2014) Effect of all-trans retinoic acid treatment on prohibitin and renin-angiotensin-aldosterone system expression in hypoxia-induced renal tubular epithelial cell injury. J Renin Angiotensin Aldosterone Syst 15 243-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Xu, T et al. (2014) Expression of PHB2 in rat brain cortex following traumatic brain injury. Int J Mol Sci 15 3299-318 PubMed GONUTS page
- ↑ Long, L et al. (2013) Dynamic change of Prohibitin2 expression in rat sciatic nerve after crush. Cell. Mol. Neurobiol. 33 689-98 PubMed GONUTS page
c
m
- Mammalia
- GO:0060749 ! mammary gland alveolus development
- GO:0060744 ! mammary gland branching involved in thelarche
- GO:0016020 ! membrane
- Metazoa
- GO:0005741 ! mitochondrial outer membrane
- GO:0005743 ! mitochondrial inner membrane
- GO:0007005 ! mitochondrion organization
- GO:0005739 ! mitochondrion
- GO:0003674 ! molecular function
- Muridae
- Murinae
- Muroidea
n
- GO:0043066 ! negative regulation of apoptotic process
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0043433 ! negative regulation of DNA-binding transcription factor activity
- GO:0033147 ! negative regulation of intracellular estrogen receptor signaling pathway
- GO:0033600 ! negative regulation of mammary gland epithelial cell proliferation
- GO:0016363 ! nuclear matrix
- GO:0005634 ! nucleus
p
- GO:0070374 ! positive regulation of ERK1 and ERK2 cascade
- GO:1902808 ! positive regulation of cell cycle G1/S phase transition
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0031536 ! positive regulation of exit from mitosis
- GO:0014069 ! postsynaptic density
- GO:0048786 ! presynaptic active zone
- GO:0032991 ! protein-containing complex
- GO:0006606 ! protein import into nucleus
- GO:0050821 ! protein stabilization
r
