RAT:OPRM

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Oprm1 (synonyms: Ror-b)
Protein Name(s)	Mu-type opioid receptor M-OR-1 MOR-1 Opioid receptor B
External Links
UniProt	P33535
EMBL	D16349 L20684 L13069 U02083 L22455 U35424 AY309003 AY309004 AY225402 AY225403 AY309000 AY309002 S77863 S75669
PIR	I56504 I56517 S69010
RefSeq	NP_001033686.1 NP_001033688.2 NP_001033689.1 NP_001033690.1 NP_037203.1
UniGene	Rn.10118
ProteinModelPortal	P33535
IntAct	P33535
STRING	10116.ENSRNOP00000057371
BindingDB	P33535
ChEMBL	CHEMBL2094129
GuidetoPHARMACOLOGY	319
PhosphoSite	P33535
Ensembl	ENSRNOT00000024682 ENSRNOT00000051837
GeneID	25601
KEGG	rno:25601
CTD	4988
RGD	3234
eggNOG	NOG279457
GeneTree	ENSGT00760000118797
HOGENOM	HOG000230486
HOVERGEN	HBG106919
InParanoid	P33535
KO	K04215
OMA	CTDPFTH
OrthoDB	EOG7BKCVQ
TreeFam	TF315737
Reactome	REACT_211747 REACT_233455 REACT_250028 REACT_250147
NextBio	607309
PRO	PR:P33535
Proteomes	UP000002494
ExpressionAtlas	P33535
Genevestigator	P33535
GO	GO:0005737 GO:0030425 GO:0032839 GO:0032590 GO:0005925 GO:0005887 GO:0016020 GO:0045121 GO:0043204 GO:0004979 GO:0031005 GO:0001965 GO:0031681 GO:0004930 GO:0038047 GO:0019904 GO:0005245 GO:0002438 GO:0007191 GO:0007193 GO:0031635 GO:0048149 GO:0070588 GO:0071315 GO:0033554 GO:0007186 GO:0006955 GO:0007626 GO:0007194 GO:0043951 GO:0051481 GO:0045019 GO:0061358 GO:0038003 GO:0007200 GO:0032100 GO:0043950 GO:0007204 GO:0070374 GO:0050769 GO:0045429 GO:0060079 GO:2000310 GO:0051930 GO:0042220 GO:0045471 GO:0032094 GO:0070848 GO:0032496 GO:0043278 GO:0019233 GO:0042060
InterPro	IPR000276 IPR017452 IPR000105 IPR001418
Pfam	PF00001
PRINTS	PR00237 PR00537 PR00384
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003924	GTPase activity	PMID:16682964^[1]	ECO:0000314			F		Figure 2a: In the presents of morphine, gene (marked with symbol mu) is found to bind to GTP. More GTP is bound when in presents of larger concentration of morphine.	complete CACAO 9819
	GO:0010975	regulation of neuron projection development	PMID:16682965^[2]	ECO:0000314			P		Figure 5: interactions of Oprm1 (designated by symbol mu in figure) in the presence of morphine is observed to increase number of cells with neurite development. Neurite development in cells increase as morphine dose increases.	complete CACAO 9821
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97266	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97266	C		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:17976846^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:17384143^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061358	negative regulation of Wnt protein secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35372	P		Seeded From UniProt	complete
involved_in	GO:0051481	negative regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35372-1	P		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42866	P		Seeded From UniProt	complete
involved_in	GO:0045019	negative regulation of nitric oxide biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35372-1	P		Seeded From UniProt	complete
involved_in	GO:0043951	negative regulation of cAMP-mediated signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35372-1	P		Seeded From UniProt	complete
enables	GO:0038047	morphine receptor activity	PMID:9224819^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42866	P		Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	PMID:9572309^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007197	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	PMID:8051154^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:1846076^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:9224819^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35372	F		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:11312309^[9]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:11312309^[9]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0097444	spine apparatus	PMID:11312309^[9]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:15748148^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	PMID:17142830^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:18065149^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	PMID:16565164^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	PMID:12710986^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	PMID:10908631^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:17156932^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:17157995^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044849	estrous cycle	PMID:21041644^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	PMID:16753266^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	PMID:16194531^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:17194545^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	PMID:15949635^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0042383	sarcolemma	PMID:15961389^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	PMID:17425581^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:17605252^[25]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038047	morphine receptor activity	PMID:19172190^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0038047	morphine receptor activity	PMID:11779147^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0038003	opioid receptor signaling pathway	PMID:19172190^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	PMID:16194531^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	PMID:16194531^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:17553897^[28]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	PMID:18805404^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032094	response to food	PMID:19301417^[30]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031681	G-protein beta-subunit binding	PMID:19682558^[31]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2716	F		Seeded From UniProt	complete
involved_in	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway	PMID:17157995^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031005	filamin binding	PMID:19172190^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:17194545^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:20214800^[32]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:735139	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:17157995^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15961389^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:22337865^[33]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:15748148^[10]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:68438	F		Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	PMID:11779147^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:11779147^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:17157995^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15961389^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:15525342^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002438	acute inflammatory response to antigenic stimulus	PMID:19298846^[35]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042923	neuropeptide binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000659780 UniProtKB:A0A1D5P5H3 UniProtKB:A0A1D5PUD6	F		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200938 ZFIN:ZDB-GENE-030729-1	F		Seeded From UniProt	complete
enables	GO:0038047	morphine receptor activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002796119 RGD:3234	F		Seeded From UniProt	complete
involved_in	GO:0038003	opioid receptor signaling pathway	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000659929 RGD:3234	P		Seeded From UniProt	complete
enables	GO:0031681	G-protein beta-subunit binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002796119 RGD:3234	F		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97441 PANTHER:PTN000659929	P		Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036789 FB:FBgn0036790 FB:FBgn0266429 MGI:MGI:97438 MGI:MGI:98327 MGI:MGI:98328 PANTHER:PTN000659780	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266429 MGI:MGI:97439 PANTHER:PTN001200938 UniProtKB:P41145 UniProtKB:P41146 ZFIN:ZDB-GENE-990415-199	C		Seeded From UniProt	complete
enables	GO:0004979	beta-endorphin receptor activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002796119 UniProtKB:P35372	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330275 PANTHER:PTN001200938 RGD:3234 UniProtKB:P41146 UniProtKB:Q9Y5Y4	F		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002796119 UniProtKB:P35372	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005245	P		Seeded From UniProt	complete
involved_in	GO:0071315	cellular response to morphine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0038047	P		Seeded From UniProt	complete
involved_in	GO:0071315	cellular response to morphine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0038047	P		Seeded From UniProt	complete
involved_in	GO:0071315	cellular response to morphine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0038047	P		Seeded From UniProt	complete
involved_in	GO:0071315	cellular response to morphine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0038047	P		Seeded From UniProt	complete
involved_in	GO:0080135	regulation of cellular response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35372 ensembl:ENSP00000394624	P		Seeded From UniProt	complete
involved_in	GO:0061358	negative regulation of Wnt protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35372 ensembl:ENSP00000394624	P		Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35372 ensembl:ENSP00000394624	P		Seeded From UniProt	complete
enables	GO:0004979	beta-endorphin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35372 ensembl:ENSP00000394624	F		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35372 ensembl:ENSP00000394624	F		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	C		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P		Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	P		Seeded From UniProt	complete
enables	GO:0004985	opioid receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42866 ensembl:ENSMUSP00000101236	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004979	beta-endorphin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000105	F		Seeded From UniProt	complete
enables	GO:0004985	opioid receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001418	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000105 InterPro:IPR000276 InterPro:IPR001418	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000105 InterPro:IPR000276 InterPro:IPR001418 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:11572871^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:11572871^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Rios, C et al. (2006) mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br. J. Pharmacol. 148 387-95 PubMed GONUTS page
↑ Christie, MJ (2006) Opioid and cannabinoid receptors: friends with benefits or just close friends? Br. J. Pharmacol. 148 385-6 PubMed GONUTS page
↑ Koyama, S & Akaike, N (2008) Activation of mu-opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons. Neurosci. Res. 60 22-8 PubMed GONUTS page
↑ Rozenfeld, R & Devi, LA (2007) Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers. FASEB J. 21 2455-65 PubMed GONUTS page
↑ ^5.0 ^5.1 Chakrabarti, S et al. (1997) The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation. Mol. Pharmacol. 52 105-13 PubMed GONUTS page
↑ Lee, JW et al. (1998) Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. J. Neurochem. 70 2203-11 PubMed GONUTS page
↑ Surratt, CK et al. (1994) -mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity. J. Biol. Chem. 269 20548-53 PubMed GONUTS page
↑ Schroeder, JE et al. (1991) Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current. Neuron 6 13-20 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Wang, H & Pickel, VM (2001) Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors. J. Neurosci. 21 3242-50 PubMed GONUTS page
↑ ^10.0 ^10.1 Wang, HL et al. (2005) Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist. J. Neurochem. 92 1285-94 PubMed GONUTS page
↑ Mousa, SA et al. (2007) Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain. Brain 130 502-13 PubMed GONUTS page
↑ McQuiston, AR (2008) Layer selective presynaptic modulation of excitatory inputs to hippocampal cornu Ammon 1 by mu-opioid receptor activation. Neuroscience 151 209-21 PubMed GONUTS page
↑ Yamamoto, T et al. (2006) Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test. J. Pharmacol. Exp. Ther. 318 206-13 PubMed GONUTS page
↑ Hurley, RW et al. (2003) Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Neuroscience 118 789-96 PubMed GONUTS page
↑ Joshi, SK et al. (2000) kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. J. Neurosci. 20 5874-9 PubMed GONUTS page
↑ Narita, M et al. (2007) Functional reduction in mu-opioidergic system in the spinal cord under a neuropathic pain-like state following chronic ethanol consumption in the rat. Neuroscience 144 777-82 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Berg, KA et al. (2007) Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Neuroscience 144 889-97 PubMed GONUTS page
↑ Chakrabarti, S et al. (2010) Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. Proc. Natl. Acad. Sci. U.S.A. 107 20115-9 PubMed GONUTS page
↑ Teodorov, E et al. (2006) Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat. Neuroscience 141 1225-31 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Drake, CT et al. (2005) Redistribution of mu-opioid receptors in C1 adrenergic neurons following chronic administration of morphine. Exp. Neurol. 196 365-72 PubMed GONUTS page
↑ ^21.0 ^21.1 Reyes, BA et al. (2007) Ultrastructural evidence for co-localization of corticotropin-releasing factor receptor and mu-opioid receptor in the rat nucleus locus coeruleus. Neurosci. Lett. 413 216-21 PubMed GONUTS page
↑ Israel, Y et al. (2005) NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Peptides 26 1167-75 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Head, BP et al. (2005) G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J. Biol. Chem. 280 31036-44 PubMed GONUTS page
↑ Jabourian, M et al. (2007) Impact of 6-hydroxydopamine lesions and cocaine exposure on mu-opioid receptor expression and regulation of cholinergic transmission in the limbic-prefrontal territory of the rat dorsal striatum. Eur. J. Neurosci. 25 1546-56 PubMed GONUTS page
↑ Cheng, B et al. (2007) [Expression of beta-endorphin and micro-opioid receptor during wound healing process in rat with deep partial-thickness scald]. Zhonghua Shao Shang Za Zhi 23 36-9 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Wang, HY & Burns, LH (2009) Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine. PLoS ONE 4 e4282 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Lengyel, I et al. (2002) Side chain modifications change the binding and agonist properties of endomorphin 2. Biochem. Biophys. Res. Commun. 290 153-61 PubMed GONUTS page
↑ Chang, SL et al. (2007) Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model. J. Virol. 81 8406-11 PubMed GONUTS page
↑ Chaijale, NN et al. (2008) A naloxonazine sensitive (mu1 receptor) mechanism in the parabrachial nucleus modulates eating. Brain Res. 1240 111-8 PubMed GONUTS page
↑ Hadjimarkou, MM et al. (2009) Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats. Synapse 63 585-97 PubMed GONUTS page
↑ Tsai, RY et al. (2009) Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein. Neuroscience 164 435-43 PubMed GONUTS page
↑ Jin, J et al. (2010) Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. BMC Neurosci 11 33 PubMed GONUTS page
↑ Feng, Y et al. (2012) Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model. Exp. Physiol. 97 651-62 PubMed GONUTS page
↑ Pasternak, DA et al. (2004) Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy. J. Neurochem. 91 881-90 PubMed GONUTS page
↑ Chen, W & Marvizón, JC (2009) Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization. Neuroscience 161 157-72 PubMed GONUTS page
↑ ^36.00 ^36.01 ^36.02 ^36.03 ^36.04 ^36.05 ^36.06 ^36.07 ^36.08 ^36.09 ^36.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^37.0 ^37.1 Kraus, J et al. (2001) Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. J. Biol. Chem. 276 43901-8 PubMed GONUTS page

[PMID:16682964-1] Rios, C et al. (2006) mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br. J. Pharmacol. 148 387-95 PubMed GONUTS page

[PMID:16682965-2] Christie, MJ (2006) Opioid and cannabinoid receptors: friends with benefits or just close friends? Br. J. Pharmacol. 148 385-6 PubMed GONUTS page

[PMID:17976846-3] Koyama, S & Akaike, N (2008) Activation of mu-opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons. Neurosci. Res. 60 22-8 PubMed GONUTS page

[PMID:17384143-4] Rozenfeld, R & Devi, LA (2007) Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers. FASEB J. 21 2455-65 PubMed GONUTS page

[PMID:9224819-5] 5.0 ^5.1 Chakrabarti, S et al. (1997) The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation. Mol. Pharmacol. 52 105-13 PubMed GONUTS page

[PMID:9572309-6] Lee, JW et al. (1998) Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. J. Neurochem. 70 2203-11 PubMed GONUTS page

[PMID:8051154-7] Surratt, CK et al. (1994) -mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity. J. Biol. Chem. 269 20548-53 PubMed GONUTS page

[PMID:1846076-8] Schroeder, JE et al. (1991) Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current. Neuron 6 13-20 PubMed GONUTS page

[PMID:11312309-9] 9.0 ^9.1 ^9.2 Wang, H & Pickel, VM (2001) Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors. J. Neurosci. 21 3242-50 PubMed GONUTS page

[PMID:15748148-10] 10.0 ^10.1 Wang, HL et al. (2005) Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist. J. Neurochem. 92 1285-94 PubMed GONUTS page

[PMID:17142830-11] Mousa, SA et al. (2007) Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain. Brain 130 502-13 PubMed GONUTS page

[PMID:18065149-12] McQuiston, AR (2008) Layer selective presynaptic modulation of excitatory inputs to hippocampal cornu Ammon 1 by mu-opioid receptor activation. Neuroscience 151 209-21 PubMed GONUTS page

[PMID:16565164-13] Yamamoto, T et al. (2006) Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test. J. Pharmacol. Exp. Ther. 318 206-13 PubMed GONUTS page

[PMID:12710986-14] Hurley, RW et al. (2003) Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Neuroscience 118 789-96 PubMed GONUTS page

[PMID:10908631-15] Joshi, SK et al. (2000) kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. J. Neurosci. 20 5874-9 PubMed GONUTS page

[PMID:17156932-16] Narita, M et al. (2007) Functional reduction in mu-opioidergic system in the spinal cord under a neuropathic pain-like state following chronic ethanol consumption in the rat. Neuroscience 144 777-82 PubMed GONUTS page

[PMID:17157995-17] 17.0 ^17.1 ^17.2 ^17.3 Berg, KA et al. (2007) Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Neuroscience 144 889-97 PubMed GONUTS page

[PMID:21041644-18] Chakrabarti, S et al. (2010) Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. Proc. Natl. Acad. Sci. U.S.A. 107 20115-9 PubMed GONUTS page

[PMID:16753266-19] Teodorov, E et al. (2006) Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat. Neuroscience 141 1225-31 PubMed GONUTS page

[PMID:16194531-20] 20.0 ^20.1 ^20.2 Drake, CT et al. (2005) Redistribution of mu-opioid receptors in C1 adrenergic neurons following chronic administration of morphine. Exp. Neurol. 196 365-72 PubMed GONUTS page

[PMID:17194545-21] 21.0 ^21.1 Reyes, BA et al. (2007) Ultrastructural evidence for co-localization of corticotropin-releasing factor receptor and mu-opioid receptor in the rat nucleus locus coeruleus. Neurosci. Lett. 413 216-21 PubMed GONUTS page

[PMID:15949635-22] Israel, Y et al. (2005) NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Peptides 26 1167-75 PubMed GONUTS page

[PMID:15961389-23] 23.0 ^23.1 ^23.2 Head, BP et al. (2005) G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J. Biol. Chem. 280 31036-44 PubMed GONUTS page

[PMID:17425581-24] Jabourian, M et al. (2007) Impact of 6-hydroxydopamine lesions and cocaine exposure on mu-opioid receptor expression and regulation of cholinergic transmission in the limbic-prefrontal territory of the rat dorsal striatum. Eur. J. Neurosci. 25 1546-56 PubMed GONUTS page

[PMID:17605252-25] Cheng, B et al. (2007) [Expression of beta-endorphin and micro-opioid receptor during wound healing process in rat with deep partial-thickness scald]. Zhonghua Shao Shang Za Zhi 23 36-9 PubMed GONUTS page

[PMID:19172190-26] 26.0 ^26.1 ^26.2 Wang, HY & Burns, LH (2009) Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine. PLoS ONE 4 e4282 PubMed GONUTS page

[PMID:11779147-27] 27.0 ^27.1 ^27.2 Lengyel, I et al. (2002) Side chain modifications change the binding and agonist properties of endomorphin 2. Biochem. Biophys. Res. Commun. 290 153-61 PubMed GONUTS page

[PMID:17553897-28] Chang, SL et al. (2007) Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model. J. Virol. 81 8406-11 PubMed GONUTS page

[PMID:18805404-29] Chaijale, NN et al. (2008) A naloxonazine sensitive (mu1 receptor) mechanism in the parabrachial nucleus modulates eating. Brain Res. 1240 111-8 PubMed GONUTS page

[PMID:19301417-30] Hadjimarkou, MM et al. (2009) Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats. Synapse 63 585-97 PubMed GONUTS page

[PMID:19682558-31] Tsai, RY et al. (2009) Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein. Neuroscience 164 435-43 PubMed GONUTS page

[PMID:20214800-32] Jin, J et al. (2010) Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. BMC Neurosci 11 33 PubMed GONUTS page

[PMID:22337865-33] Feng, Y et al. (2012) Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model. Exp. Physiol. 97 651-62 PubMed GONUTS page

[PMID:15525342-34] Pasternak, DA et al. (2004) Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy. J. Neurochem. 91 881-90 PubMed GONUTS page

[PMID:19298846-35] Chen, W & Marvizón, JC (2009) Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization. Neuroscience 161 157-72 PubMed GONUTS page

[PMID:21873635-36] 36.00 ^36.01 ^36.02 ^36.03 ^36.04 ^36.05 ^36.06 ^36.07 ^36.08 ^36.09 ^36.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11572871-37] 37.0 ^37.1 Kraus, J et al. (2001) Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. J. Biol. Chem. 276 43901-8 PubMed GONUTS page

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