GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16682965
| Citation |
Christie, MJ (2006) Opioid and cannabinoid receptors: friends with benefits or just close friends? Br. J. Pharmacol. 148:385-6 |
|---|---|
| Abstract |
mu-Opioid (MOP) and cannabinoid CB1 receptors mediate overlapping pharmacological responses in clinically important areas such as drug abuse and pain management, and functional interactions between agonists at these receptors have long been recognized. In the present issue of this Journal, Rios and co-workers have provided the first strong evidence that the two receptors interact directly when coexpressed in the same cells. The authors report a close physical association between MOP and CB1 receptors and novel pharmacological interactions of MOP and CB1 agonists. They argue that MOP/CB1 heterodimer formation explains these interactions. If correct, the direct interaction of MOP and CB1 pharmacophores in a quaternary complex would provide real benefits by opening the potential for development of novel MOP/CB1 small molecules or new strategies for use of current ligands. However, a lot more evidence will be required before the heterodimer interpretation can be accepted. If it turns out that MOP and CB1 receptors do not readily form hetero-oligomers, the study by Rios and co-workers shows that they are still friends but there may be few benefits. |
| Links |
PubMed PMC1751787 Online version:10.1038/sj.bjp.0706756 |
| Keywords |
Animals; Dimerization; Fluorescence Resonance Energy Transfer; Humans; Luminescence; Receptor, Cannabinoid, CB1/chemistry; Receptor, Cannabinoid, CB1/physiology; Receptors, Opioid, mu/chemistry; Receptors, Opioid, mu/physiology; Signal Transduction |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0010975: regulation of neuron projection development |
ECO:0000314: |
P |
Figure 5: interactions of Oprm1 (designated by symbol mu in figure) in the presence of morphine is observed to increase number of cells with neurite development. Neurite development in cells increase as morphine dose increases. |
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See also
References
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