RAT:NRX1B

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Nrxn1
Protein Name(s)	Neurexin-1-beta Neurexin I-beta
External Links
UniProt	Q63373
EMBL	M96375
PIR	B40228
UniGene	Rn.54924
PDB	1C4R 2R1B 2R1D 2WQZ 2XB6
PDBsum	1C4R 2R1B 2R1D 2WQZ 2XB6
ProteinModelPortal	Q63373
SMR	Q63373
DIP	DIP-40508N
IntAct	Q63373
MINT	MINT-1519111
PRIDE	Q63373
UCSC	RGD:628659
RGD	628659
HOVERGEN	HBG052670
PhylomeDB	Q63373
EvolutionaryTrace	Q63373
Proteomes	UP000002494
Genevestigator	Q63373
GO	GO:0044295 GO:0030054 GO:0009986 GO:0030139 GO:0016021 GO:0005886 GO:0045202 GO:0005509 GO:0048306 GO:0050839 GO:0097109 GO:0005102 GO:0001525 GO:0016339 GO:0021707 GO:0045184 GO:0097112 GO:0097116 GO:0097117 GO:0007157 GO:0097114 GO:0051490 GO:0097118 GO:0007158 GO:0090004 GO:2000463 GO:0051968 GO:0097119 GO:0097104 GO:0097105 GO:0090126 GO:0051290 GO:0035418 GO:0097120 GO:2000311 GO:2000310 GO:0007416 GO:0007268 GO:0097091
Gene3D	2.60.120.200
InterPro	IPR013320 IPR001791 IPR029824 IPR003585 IPR027789
PANTHER	PTHR10127:SF565
Pfam	PF02210 PF01034
SMART	SM00294 SM00282
SUPFAM	SSF49899
PROSITE	PS50025

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042734	presynaptic membrane	PMID:17868325^[1]	ECO:0000314			C		See Fig 5. Neurexin is largely presynaptic and binds with neuroligin normally to form trans-synaptic complexes and transduce bidirectional signals across the membrane.	complete
	GO:0001525	angiogenesis	GO_REF:0000024	ECO:0000250		UniProtKB:D0PRN2	P			complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:14522992^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	PMID:14522992^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62765	F	part_of:(GO:0071277)	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:15797875^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:15797875^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(UBERON:0014554)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
involved_in	GO:0090126	protein-containing complex assembly involved in synapse maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097117	guanylate kinase-associated protein clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097112	gamma-aminobutyric acid receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	PMID:19730411^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	PMID:15797875^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	PMID:15152050^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62889	F		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0051490	negative regulation of filopodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:19730411^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:15797875^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:15152050^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62889	F		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	F		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	PMID:15797875^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0021707	cerebellar granule cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:15797875^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:15797875^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D0PRN2	P		Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[6]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[6]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	PMID:18093522^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0036057	slit diaphragm	PMID:21048075^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:22662246^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18755801^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:18334216^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037440	C		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	PMID:15797875^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905520	positive regulation of presynaptic active zone assembly	PMID:15797875^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:15797875^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:15797875^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Berninghausen, O et al. (2007) Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses. J. Neurochem. 103 1855-63 PubMed GONUTS page
↑ ^2.0 ^2.1 Comoletti, D et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J. Biol. Chem. 278 50497-505 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Chubykin, AA et al. (2005) Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J. Biol. Chem. 280 22365-74 PubMed GONUTS page
↑ ^4.0 ^4.1 Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page
↑ ^5.0 ^5.1 Comoletti, D et al. (2004) The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J. Neurosci. 24 4889-93 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Dean, C et al. (2003) Neurexin mediates the assembly of presynaptic terminals. Nat. Neurosci. 6 708-16 PubMed GONUTS page
↑ Araç, D et al. (2007) Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 56 992-1003 PubMed GONUTS page
↑ Saito, A et al. (2011) Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300 R340-8 PubMed GONUTS page
↑ Shapiro-Reznik, M et al. (2012) Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock. PLoS ONE 7 e37894 PubMed GONUTS page
↑ Suckow, AT et al. (2008) Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology 149 6006-17 PubMed GONUTS page
↑ Koehnke, J et al. (2008) Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure 16 410-21 PubMed GONUTS page

[PMID:17868325-1] Berninghausen, O et al. (2007) Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses. J. Neurochem. 103 1855-63 PubMed GONUTS page

[PMID:14522992-2] 2.0 ^2.1 Comoletti, D et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J. Biol. Chem. 278 50497-505 PubMed GONUTS page

[PMID:15797875-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Chubykin, AA et al. (2005) Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J. Biol. Chem. 280 22365-74 PubMed GONUTS page

[PMID:19730411-4] 4.0 ^4.1 Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page

[PMID:15152050-5] 5.0 ^5.1 Comoletti, D et al. (2004) The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J. Neurosci. 24 4889-93 PubMed GONUTS page

[PMID:12796785-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Dean, C et al. (2003) Neurexin mediates the assembly of presynaptic terminals. Nat. Neurosci. 6 708-16 PubMed GONUTS page

[PMID:18093522-7] Araç, D et al. (2007) Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 56 992-1003 PubMed GONUTS page

[PMID:21048075-8] Saito, A et al. (2011) Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300 R340-8 PubMed GONUTS page

[PMID:22662246-9] Shapiro-Reznik, M et al. (2012) Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock. PLoS ONE 7 e37894 PubMed GONUTS page

[PMID:18755801-10] Suckow, AT et al. (2008) Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology 149 6006-17 PubMed GONUTS page

[PMID:18334216-11] Koehnke, J et al. (2008) Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure 16 410-21 PubMed GONUTS page

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RAT:NRX1B

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