RAT:NF2L2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Nfe2l2 (synonyms: Nrf2)
Protein Name(s)	Nuclear factor erythroid 2-related factor 2 NF-E2-related factor 2 NFE2-related factor 2 Nuclear factor, erythroid derived 2, like 2
External Links
UniProt	O54968
EMBL	AF037350 BC061724
RefSeq	NP_113977.1 XP_006234458.1
UniGene	Rn.10867
ProteinModelPortal	O54968
BioGrid	249784
STRING	10116.ENSRNOP00000002114
ChEMBL	CHEMBL1075141
iPTMnet	O54968
PhosphoSite	O54968
PaxDb	O54968
Ensembl	ENSRNOT00000002114
GeneID	83619
KEGG	rno:83619
UCSC	RGD:620360
CTD	4780
RGD	620360
eggNOG	ENOG410KDJ5 ENOG41100FB
GeneTree	ENSGT00830000128250
HOGENOM	HOG000234410
HOVERGEN	HBG052609
InParanoid	O54968
KO	K05638
PhylomeDB	O54968
NextBio	616181
PRO	PR:O54968
Proteomes	UP000002494
ExpressionAtlas	O54968
GO	GO:0005813 GO:0000785 GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0005886 GO:0032993 GO:0000980 GO:0043565 GO:0001221 GO:0003700 GO:0000976 GO:0001205 GO:0045454 GO:0035690 GO:0071498 GO:0042149 GO:0070301 GO:0071456 GO:0071499 GO:0071356 GO:0006954 GO:0010667 GO:0060548 GO:2000352 GO:1902037 GO:1903206 GO:1902176 GO:1904753 GO:0036499 GO:0045766 GO:0030194 GO:0043536 GO:0046326 GO:1903788 GO:0010976 GO:2000379 GO:0045944 GO:0036091 GO:0010499 GO:0043161 GO:0016567 GO:0045995 GO:2000121
Gene3D	1.10.880.10
InterPro	IPR004827 IPR004826 IPR029845 IPR008917
PANTHER	PTHR24411:SF3
Pfam	PF03131
SMART	SM00338
SUPFAM	SSF47454
PROSITE	PS50217 PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P	Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P	Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:16314513^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P	Seeded From UniProt	complete
involved_in	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16314513^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	PMID:16314513^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6IRI7	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:16314513^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	PMID:23413426^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904385	cellular response to angiotensin	PMID:26637559^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:23904790^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:24048861^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:19735445^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046223	aflatoxin catabolic process	PMID:27071940^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:23904790^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:19735445^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:23904790^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:19762340^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	PMID:23453443^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:16155909^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18787991^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20554019^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18787991^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696622	P	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696686	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696622 RGD:620360 UniProtKB:Q16236	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 MGI:MGI:97308 MGI:MGI:99421 PANTHER:PTN000696622 RGD:620360 UniProtKB:Q14494 UniProtKB:Q16236 ZFIN:ZDB-GENE-030723-2	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696622 UniProtKB:Q16236 ZFIN:ZDB-GENE-030723-2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000696622 RGD:620360 ZFIN:ZDB-GENE-030723-2	F	Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0071499	cellular response to laminar fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	F	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
involved_in	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	F	Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	F	Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:2000121	regulation of removal of superoxide radicals	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:1903788	positive regulation of glutathione biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:1902037	negative regulation of hematopoietic stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0061396	regulation of transcription from RNA polymerase II promoter in response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0045995	regulation of embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0036499	PERK-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	C	Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0030194	positive regulation of blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	F	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	F	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	F	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	F	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60795 ensembl:ENSMUSP00000099733	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR008917 InterPro:IPR029845	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827 InterPro:IPR029845	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR029845	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029845	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR004827 InterPro:IPR008917	P	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029845	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Nioi, P et al. (2005) The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Mol. Cell. Biol. 25 10895-906 PubMed GONUTS page
↑ Ashino, T et al. (2013) Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia. Arterioscler. Thromb. Vasc. Biol. 33 760-8 PubMed GONUTS page
↑ Priestley, JR et al. (2016) The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. Am. J. Physiol. Heart Circ. Physiol. 310 H478-87 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Kuang, L et al. (2013) Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions. Int. J. Biol. Sci. 9 656-65 PubMed GONUTS page
↑ Huang, XS et al. (2014) Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection. Mol. Cell. Biochem. 385 33-41 PubMed GONUTS page
↑ ^6.0 ^6.1 Minelli, A et al. (2009) Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling. J. Neurochem. 111 956-66 PubMed GONUTS page
↑ Taguchi, K et al. (2016) Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Toxicol. Sci. 152 40-52 PubMed GONUTS page
↑ Kosaka, K et al. (2010) Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. J. Biochem. 147 73-81 PubMed GONUTS page
↑ Tsai, CY et al. (2013) Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes. Int. J. Cardiol. 168 1286-97 PubMed GONUTS page
↑ Li, M et al. (2006) Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression. J. Cell. Physiol. 206 518-25 PubMed GONUTS page
↑ ^11.0 ^11.1 Yan, W et al. (2008) Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats. Brain Inj 22 802-10 PubMed GONUTS page
↑ Arredondo, F et al. (2010) After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Free Radic. Biol. Med. 49 738-47 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16314513-1] 1.0 ^1.1 ^1.2 ^1.3 Nioi, P et al. (2005) The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Mol. Cell. Biol. 25 10895-906 PubMed GONUTS page

[PMID:23413426-2] Ashino, T et al. (2013) Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia. Arterioscler. Thromb. Vasc. Biol. 33 760-8 PubMed GONUTS page

[PMID:26637559-3] Priestley, JR et al. (2016) The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. Am. J. Physiol. Heart Circ. Physiol. 310 H478-87 PubMed GONUTS page

[PMID:23904790-4] 4.0 ^4.1 ^4.2 Kuang, L et al. (2013) Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions. Int. J. Biol. Sci. 9 656-65 PubMed GONUTS page

[PMID:24048861-5] Huang, XS et al. (2014) Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection. Mol. Cell. Biochem. 385 33-41 PubMed GONUTS page

[PMID:19735445-6] 6.0 ^6.1 Minelli, A et al. (2009) Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling. J. Neurochem. 111 956-66 PubMed GONUTS page

[PMID:27071940-7] Taguchi, K et al. (2016) Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Toxicol. Sci. 152 40-52 PubMed GONUTS page

[PMID:19762340-8] Kosaka, K et al. (2010) Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. J. Biochem. 147 73-81 PubMed GONUTS page

[PMID:23453443-9] Tsai, CY et al. (2013) Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes. Int. J. Cardiol. 168 1286-97 PubMed GONUTS page

[PMID:16155909-10] Li, M et al. (2006) Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression. J. Cell. Physiol. 206 518-25 PubMed GONUTS page

[PMID:18787991-11] 11.0 ^11.1 Yan, W et al. (2008) Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats. Brain Inj 22 802-10 PubMed GONUTS page

[PMID:20554019-12] Arredondo, F et al. (2010) After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Free Radic. Biol. Med. 49 738-47 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:NF2L2

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