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PMID:18787991
| Citation |
Yan, W, Wang, HD, Zhu, L, Feng, XM, Qiao, L, Jin, W and Tang, K (2008) Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats. Brain Inj 22:802-10 |
|---|---|
| Abstract |
Acute lung injury (ALI) is a frequent but poorly understood complication of traumatic brain injury (TBI). The Nrf2-ARE pathway has been proved to be essential for protection against diffuse inflammation and oxidative damage, which are both involved in ALI following TBI. However, whether the Nrf2-ARE pathway is activated after TBI in the lung hasn't been studied. |
| Links |
PubMed Online version:10.1080/02699050802372174 |
| Keywords |
Acute Lung Injury/etiology; Acute Lung Injury/metabolism; Animals; Antioxidants/metabolism; Brain Injuries/complications; Brain Injuries/metabolism; Gene Expression Regulation/physiology; Heme Oxygenase-1/metabolism; Immunohistochemistry; Macrophages, Alveolar/metabolism; Male; NADP/metabolism; NF-E2-Related Factor 2/metabolism; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/physiology; Trachea/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
Notes
See also
References
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