RAT:NDKA

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Nme1
Protein Name(s)	Nucleoside diphosphate kinase A NDK A NDP kinase A Metastasis inhibition factor NM23 Tumor metastatic process-associated protein
External Links
UniProt	Q05982
EMBL	D13374
PIR	A45208
RefSeq	NP_612557.1
UniGene	Rn.6236
ProteinModelPortal	Q05982
SMR	Q05982
BioGrid	251322
IntAct	Q05982
STRING	10116.ENSRNOP00000003658
PhosphoSite	Q05982
PaxDb	Q05982
PRIDE	Q05982
Ensembl	ENSRNOT00000003658
GeneID	191575
KEGG	rno:191575
CTD	4830
RGD	70497
eggNOG	COG0105
GeneTree	ENSGT00760000119146
HOGENOM	HOG000224564
HOVERGEN	HBG000423
InParanoid	Q05982
KO	K00940
OMA	VERFFME
OrthoDB	EOG7GJ6FG
PhylomeDB	Q05982
TreeFam	TF106373
Reactome	REACT_215006
SABIO-RK	Q05982
NextBio	622659
PRO	PR:Q05982
Proteomes	UP000002494
ExpressionAtlas	Q05982
Genevestigator	Q05982
GO	GO:0071944 GO:0005813 GO:0005829 GO:0070062 GO:0030027 GO:0016020 GO:0005634 GO:0048471 GO:0001726 GO:0005524 GO:0019899 GO:0043015 GO:0019215 GO:0046872 GO:0004550 GO:0019901 GO:0000977 GO:0003697 GO:0035690 GO:0071398 GO:0071333 GO:0006241 GO:0006897 GO:0006183 GO:0021766 GO:0007229 GO:0043066 GO:0010629 GO:0002762 GO:0006165 GO:0050679 GO:0045618 GO:0010976 GO:0045944 GO:0014075 GO:0051591 GO:0042493 GO:0033574 GO:0006228
Gene3D	3.30.70.141
HAMAP	MF_00451
InterPro	IPR001564 IPR023005
Pfam	PF00334
PRINTS	PR01243
SMART	SM00562
SUPFAM	SSF54919
PROSITE	PS00469

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005741	mitochondrial outer membrane	PMID:22817458^[1]	ECO:0000314			C	Figure 4	complete CACAO 6293
part_of	GO:0005741	mitochondrial outer membrane	PMID:22817458^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	PMID:19367376^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:19367376^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	PMID:11082283^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:11082283^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	PMID:11139339^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:11082283^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:11082283^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	PMID:19639176^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	PMID:18493952^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:17572440^[7]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2997	F	Seeded From UniProt	complete
enables	GO:0019215	intermediate filament binding	PMID:11082283^[3]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2679	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11872741^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0014075	response to amine	PMID:19639176^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:10069391^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:12010125^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006165	nucleoside diphosphate phosphorylation	PMID:11139339^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0005882	intermediate filament	PMID:11082283^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11831846^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:11139339^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	PMID:11139339^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:12010125^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002762	negative regulation of myeloid leukocyte differentiation	PMID:7737424^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:12010125^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10650 FB:FBgn0000150 PANTHER:PTN000887110 PomBase:SPAC806.07 RGD:619877 RGD:70497 SGD:S000001550 TAIR:locus:2137936 TAIR:locus:2161922 UniProtKB:O00746 UniProtKB:P15531 UniProtKB:P22392 UniProtKB:Q59636 UniProtKB:Q8ID43 ZFIN:ZDB-GENE-000210-33 dictyBase:DDB_G0273069	F	Seeded From UniProt	complete
involved_in	GO:0006259	DNA metabolic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004536	P	Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15532 ensembl:ENSMUSP00000117022	P	Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15532 ensembl:ENSMUSP00000117022	P	Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	P	Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	P	Seeded From UniProt	complete
enables	GO:0043024	ribosomal small subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F	Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	C	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F	Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F	Seeded From UniProt	complete
enables	GO:0004536	deoxyribonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F	Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	F	Seeded From UniProt	complete
involved_in	GO:0006165	nucleoside diphosphate phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	P	Seeded From UniProt	complete
involved_in	GO:0006183	GTP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	P	Seeded From UniProt	complete
involved_in	GO:0006228	UTP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	P	Seeded From UniProt	complete
involved_in	GO:0006241	CTP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	P	Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.4.6	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0009117	nucleotide metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0546	P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lipskaya, TY & Voinova, VV (2012) Activity of nucleoside diphosphate kinase α (NDPK α) capable of binding to outer mitochondrial membrane accounts for less than 10% of total NDPK activity present in cytoplasm of liver cells. Biochemistry Mosc. 77 593-602 PubMed GONUTS page
↑ ^2.0 ^2.1 Veluthakal, R et al. (2009) Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity. Mol. Cell. Biochem. 329 121-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Roymans, D et al. (2000) Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma. Exp. Cell Res. 261 127-38 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Roymans, D et al. (2001) Identification of the tumor metastasis suppressor Nm23-H1/Nm23-R1 as a constituent of the centrosome. Exp. Cell Res. 262 145-53 PubMed GONUTS page
↑ ^5.0 ^5.1 Boyiri, T et al. (2009) Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination. Int. J. Oncol. 35 559-67 PubMed GONUTS page
↑ Weitzdörfer, R et al. (2008) Changes of hippocampal signaling protein levels during postnatal brain development in the rat. Hippocampus 18 807-13 PubMed GONUTS page
↑ Jovanović, S et al. (2007) M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo. J. Mol. Biol. 371 349-61 PubMed GONUTS page
↑ Baillat, G et al. (2002) Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I. J. Biol. Chem. 277 18961-6 PubMed GONUTS page
↑ Ishijima, Y et al. (1999) Overexpression of nucleoside diphosphate kinases induces neurite outgrowth and their substitution to inactive forms leads to suppression of nerve growth factor- and dibutyryl cyclic AMP-induced effects in PC12D cells. FEBS Lett. 445 155-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Cheng, S et al. (2002) Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Biochem. J. 366 807-16 PubMed GONUTS page
↑ Kowluru, A et al. (2002) Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. Arch. Biochem. Biophys. 398 160-9 PubMed GONUTS page
↑ Okabe-Kado, J et al. (1995) A new function of Nm23/NDP kinase as a differentiation inhibitory factor, which does not require it's kinase activity. FEBS Lett. 363 311-5 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22817458-1] 1.0 ^1.1 Lipskaya, TY & Voinova, VV (2012) Activity of nucleoside diphosphate kinase α (NDPK α) capable of binding to outer mitochondrial membrane accounts for less than 10% of total NDPK activity present in cytoplasm of liver cells. Biochemistry Mosc. 77 593-602 PubMed GONUTS page

[PMID:19367376-2] 2.0 ^2.1 Veluthakal, R et al. (2009) Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity. Mol. Cell. Biochem. 329 121-9 PubMed GONUTS page

[PMID:11082283-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Roymans, D et al. (2000) Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma. Exp. Cell Res. 261 127-38 PubMed GONUTS page

[PMID:11139339-4] 4.0 ^4.1 ^4.2 ^4.3 Roymans, D et al. (2001) Identification of the tumor metastasis suppressor Nm23-H1/Nm23-R1 as a constituent of the centrosome. Exp. Cell Res. 262 145-53 PubMed GONUTS page

[PMID:19639176-5] 5.0 ^5.1 Boyiri, T et al. (2009) Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination. Int. J. Oncol. 35 559-67 PubMed GONUTS page

[PMID:18493952-6] Weitzdörfer, R et al. (2008) Changes of hippocampal signaling protein levels during postnatal brain development in the rat. Hippocampus 18 807-13 PubMed GONUTS page

[PMID:17572440-7] Jovanović, S et al. (2007) M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo. J. Mol. Biol. 371 349-61 PubMed GONUTS page

[PMID:11872741-8] Baillat, G et al. (2002) Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I. J. Biol. Chem. 277 18961-6 PubMed GONUTS page

[PMID:10069391-9] Ishijima, Y et al. (1999) Overexpression of nucleoside diphosphate kinases induces neurite outgrowth and their substitution to inactive forms leads to suppression of nerve growth factor- and dibutyryl cyclic AMP-induced effects in PC12D cells. FEBS Lett. 445 155-9 PubMed GONUTS page

[PMID:12010125-10] 10.0 ^10.1 ^10.2 Cheng, S et al. (2002) Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Biochem. J. 366 807-16 PubMed GONUTS page

[PMID:11831846-11] Kowluru, A et al. (2002) Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. Arch. Biochem. Biophys. 398 160-9 PubMed GONUTS page

[PMID:7737424-12] Okabe-Kado, J et al. (1995) A new function of Nm23/NDP kinase as a differentiation inhibitory factor, which does not require it's kinase activity. FEBS Lett. 363 311-5 PubMed GONUTS page

[PMID:21873635-13] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:NDKA

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