RAT:IREB2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ireb2 (synonyms: Irp2)
Protein Name(s)	Iron-responsive element-binding protein 2 IRE-BP 2 Iron regulatory protein 2 IRP2
External Links
UniProt	Q62751
EMBL	U20181 BC081798
PIR	A57238
RefSeq	NP_074054.2
UniGene	Rn.10132
ProteinModelPortal	Q62751
SMR	Q62751
STRING	10116.ENSRNOP00000017900
PhosphoSite	Q62751
PaxDb	Q62751
PRIDE	Q62751
Ensembl	ENSRNOT00000017900
GeneID	64831
KEGG	rno:64831
UCSC	RGD:621539
CTD	3658
RGD	621539
eggNOG	COG1048
GeneTree	ENSGT00760000119287
HOGENOM	HOG000025704
HOVERGEN	HBG052147
InParanoid	Q62751
OMA	PCRGQTT
OrthoDB	EOG7CG6Z7
PhylomeDB	Q62751
TreeFam	TF313476
NextBio	613756
PRO	PR:Q62751
Proteomes	UP000002494
Genevestigator	Q62751
GO	GO:0005829 GO:0005739 GO:0051539 GO:0030350 GO:0046872 GO:0030371 GO:0007568 GO:0006879 GO:0071456 GO:0034101 GO:0050892 GO:0055072 GO:0006826 GO:0030316 GO:0009791 GO:0006782 GO:0010040 GO:0032526
Gene3D	3.20.19.10 3.30.499.10 3.40.1060.10
InterPro	IPR015931 IPR015937 IPR001030 IPR015928 IPR006249 IPR015932 IPR018136 IPR000573 IPR029755
PANTHER	PTHR11670 PTHR11670:SF31
Pfam	PF00330 PF00694
PRINTS	PR00415
SUPFAM	SSF52016 SSF53732
TIGRFAMs	TIGR01341
PROSITE	PS00450 PS01244

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0055072	iron ion homeostasis	PMID:7665579^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	PMID:7665579^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0030350	iron-responsive element binding	PMID:7665579^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1990910	response to hypobaric hypoxia	PMID:27925282^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904373	response to kainic acid	PMID:16328268^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090650	cellular response to oxygen-glucose deprivation	PMID:16135072^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072705	cellular response to mercaptoethanol	PMID:16135072^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:22159112^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0035103	sterol regulatory element binding protein cleavage	PMID:23806658^[6]	ECO:0000316		PMID:12923525^[7]	P	Figure 5, intracellular aconitase function of IRP1 mutant	complete CACAO 8759
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:10889193^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:22154532^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	PMID:16568477^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	PMID:17469137^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071283	cellular response to iron(III) ion	PMID:16135072^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071283	cellular response to iron(III) ion	PMID:17469137^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046688	response to copper ion	PMID:24024382^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:12111837^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:19877527^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:12111837^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:7523370^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	PMID:24184442^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014732	skeletal muscle atrophy	PMID:23994517^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010043	response to zinc ion	PMID:24024381^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010041	response to iron(III) ion	PMID:21753061^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010040	response to iron(II) ion	PMID:19943190^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:19943190^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:12111837^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21753061^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21753061^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001069	regulatory region RNA binding	PMID:7523370^[15]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:733275	F	Seeded From UniProt	complete
enables	GO:0001069	regulatory region RNA binding	PMID:16135072^[4]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:732498	F	Seeded From UniProt	complete
involved_in	GO:1990910	response to hypobaric hypoxia	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:1904373	response to kainic acid	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0090650	cellular response to oxygen-glucose deprivation	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0072705	cellular response to mercaptoethanol	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0071283	cellular response to iron(III) ion	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11325 PANTHER:PTN000186700 RGD:621539 UniProtKB:P09339 UniProtKB:P21399 UniProtKB:Q0VCU1	F	Seeded From UniProt	complete
involved_in	GO:0046688	response to copper ion	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0034101	erythrocyte homeostasis	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928268 PANTHER:PTN002617314	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	C	Seeded From UniProt	complete
enables	GO:0030350	iron-responsive element binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928268 PANTHER:PTN002617314 RGD:621539	F	Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928268 PANTHER:PTN002617314	P	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0014732	skeletal muscle atrophy	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0010043	response to zinc ion	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0010041	response to iron(III) ion	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0010040	response to iron(II) ion	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928268 PANTHER:PTN002617314	P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	P	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928268 PANTHER:PTN002617314	P	Seeded From UniProt	complete
involved_in	GO:0006782	protoporphyrinogen IX biosynthetic process	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928268 PANTHER:PTN002617314	P	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928268 PANTHER:PTN002617314	P	Seeded From UniProt	complete
involved_in	GO:0006101	citrate metabolic process	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000186700 TAIR:locus:2116297 UniProtKB:P21399 UniProtKB:Q0VCU1 UniProtKB:Q42560	P	Seeded From UniProt	complete
involved_in	GO:0006099	tricarboxylic acid cycle	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000186700 UniProtKB:Q8ZP52	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11325 MGI:MGI:1928268 MGI:MGI:87879 PANTHER:PTN000186700 RGD:2019 RGD:621539 UniProtKB:P21399 UniProtKB:Q42560 UniProtKB:Q8IDR8 WB:WBGene00000040	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002268875 TAIR:locus:2116297 UniProtKB:P21399 UniProtKB:Q42560 UniProtKB:Q8IDR8	C	Seeded From UniProt	complete
enables	GO:0003994	aconitate hydratase activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11325 FB:FBgn0024957 FB:FBgn0024958 MGI:MGI:87879 PANTHER:PTN000186700 RGD:2019 TAIR:locus:2063354 TAIR:locus:2116297 UniProtKB:P09339 UniProtKB:P21399 UniProtKB:Q0VCU1 UniProtKB:Q42560 UniProtKB:Q8IDR8 UniProtKB:Q8ZP52 WB:WBGene00000040	F	Seeded From UniProt	complete
enables	GO:0001069	regulatory region RNA binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002617314 RGD:621539	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029755	C	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029755	P	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029755	P	Seeded From UniProt	complete
enables	GO:0030350	iron-responsive element binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029755	F	Seeded From UniProt	complete
enables	GO:0030371	translation repressor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029755	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0004	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Guo, B et al. (1995) Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J. Biol. Chem. 270 21645-51 PubMed GONUTS page
↑ Li, Y et al. (2017) Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats. J. Cell. Biochem. 118 1596-1605 PubMed GONUTS page
↑ Huang, E et al. (2006) Upregulation of iron regulatory proteins and divalent metal transporter-1 isoforms in the rat hippocampus after kainate induced neuronal injury. Exp Brain Res 170 376-86 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Irace, C et al. (2005) Divergent modulation of iron regulatory proteins and ferritin biosynthesis by hypoxia/reoxygenation in neurones and glial cells. J. Neurochem. 95 1321-31 PubMed GONUTS page
↑ Rathnasamy, G et al. (2011) Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species. J. Neurosci. 31 17982-95 PubMed GONUTS page
↑ Selezneva, AI et al. (2013) Nucleotide-specific recognition of iron-responsive elements by iron regulatory protein 1. J. Mol. Biol. 425 3301-10 PubMed GONUTS page
↑ Rawson, RB (2003) The SREBP pathway--insights from Insigs and insects. Nat. Rev. Mol. Cell Biol. 4 631-40 PubMed GONUTS page
↑ Thomson, AM et al. (2000) Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways. J. Biol. Chem. 275 31609-15 PubMed GONUTS page
↑ Jiang, S et al. (2012) Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2. Nutrition 28 281-7 PubMed GONUTS page
↑ Kwik-Uribe, C & Smith, DR (2006) Temporal responses in the disruption of iron regulation by manganese. J. Neurosci. Res. 83 1601-10 PubMed GONUTS page
↑ ^11.0 ^11.1 Crooks, DR et al. (2007) Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J. Neurosci. Res. 85 1797-809 PubMed GONUTS page
↑ Xiao, F et al. (2013) [Effects of copper deficiency on iron metabolism in rats]. Wei Sheng Yan Jiu 42 652-5 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Siddappa, AJ et al. (2002) Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J. Neurosci. Res. 68 761-75 PubMed GONUTS page
↑ Lan, L et al. (2009) [Effect of all-trans retinoic acid deficiency on iron metabolism in rat primary hepatocyte]. Wei Sheng Yan Jiu 38 603-6 PubMed GONUTS page
↑ ^15.0 ^15.1 Guo, B et al. (1994) Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. J. Biol. Chem. 269 24252-60 PubMed GONUTS page
↑ Chen, Q & Xiao, DS (2014) Long-term aerobic exercise increases redox-active iron through nitric oxide in rat hippocampus. Nitric Oxide 36 1-10 PubMed GONUTS page
↑ DeRuisseau, KC et al. (2013) Aging-related changes in the iron status of skeletal muscle. Exp. Gerontol. 48 1294-302 PubMed GONUTS page
↑ Yang, L et al. (2013) [Effects of different zinc nutritional status on iron metabolism in rats]. Wei Sheng Yan Jiu 42 647-51 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Davis, MR et al. (2011) Hypoxia inducible factor-2 α is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats. J. Nutr. 141 1590-6 PubMed GONUTS page
↑ ^20.0 ^20.1 Dornelles, AS et al. (2010) mRNA expression of proteins involved in iron homeostasis in brain regions is altered by age and by iron overloading in the neonatal period. Neurochem. Res. 35 564-71 PubMed GONUTS page
↑ ^21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 ^21.11 ^21.12 ^21.13 ^21.14 ^21.15 ^21.16 ^21.17 ^21.18 ^21.19 ^21.20 ^21.21 ^21.22 ^21.23 ^21.24 ^21.25 ^21.26 ^21.27 ^21.28 ^21.29 ^21.30 ^21.31 ^21.32 ^21.33 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7665579-1] 1.0 ^1.1 ^1.2 Guo, B et al. (1995) Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J. Biol. Chem. 270 21645-51 PubMed GONUTS page

[PMID:27925282-2] Li, Y et al. (2017) Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats. J. Cell. Biochem. 118 1596-1605 PubMed GONUTS page

[PMID:16328268-3] Huang, E et al. (2006) Upregulation of iron regulatory proteins and divalent metal transporter-1 isoforms in the rat hippocampus after kainate induced neuronal injury. Exp Brain Res 170 376-86 PubMed GONUTS page

[PMID:16135072-4] 4.0 ^4.1 ^4.2 ^4.3 Irace, C et al. (2005) Divergent modulation of iron regulatory proteins and ferritin biosynthesis by hypoxia/reoxygenation in neurones and glial cells. J. Neurochem. 95 1321-31 PubMed GONUTS page

[PMID:22159112-5] Rathnasamy, G et al. (2011) Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species. J. Neurosci. 31 17982-95 PubMed GONUTS page

[PMID:23806658-6] Selezneva, AI et al. (2013) Nucleotide-specific recognition of iron-responsive elements by iron regulatory protein 1. J. Mol. Biol. 425 3301-10 PubMed GONUTS page

[PMID:12923525-7] Rawson, RB (2003) The SREBP pathway--insights from Insigs and insects. Nat. Rev. Mol. Cell Biol. 4 631-40 PubMed GONUTS page

[PMID:10889193-8] Thomson, AM et al. (2000) Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways. J. Biol. Chem. 275 31609-15 PubMed GONUTS page

[PMID:22154532-9] Jiang, S et al. (2012) Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2. Nutrition 28 281-7 PubMed GONUTS page

[PMID:16568477-10] Kwik-Uribe, C & Smith, DR (2006) Temporal responses in the disruption of iron regulation by manganese. J. Neurosci. Res. 83 1601-10 PubMed GONUTS page

[PMID:17469137-11] 11.0 ^11.1 Crooks, DR et al. (2007) Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J. Neurosci. Res. 85 1797-809 PubMed GONUTS page

[PMID:24024382-12] Xiao, F et al. (2013) [Effects of copper deficiency on iron metabolism in rats]. Wei Sheng Yan Jiu 42 652-5 PubMed GONUTS page

[PMID:12111837-13] 13.0 ^13.1 ^13.2 Siddappa, AJ et al. (2002) Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J. Neurosci. Res. 68 761-75 PubMed GONUTS page

[PMID:19877527-14] Lan, L et al. (2009) [Effect of all-trans retinoic acid deficiency on iron metabolism in rat primary hepatocyte]. Wei Sheng Yan Jiu 38 603-6 PubMed GONUTS page

[PMID:7523370-15] 15.0 ^15.1 Guo, B et al. (1994) Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. J. Biol. Chem. 269 24252-60 PubMed GONUTS page

[PMID:24184442-16] Chen, Q & Xiao, DS (2014) Long-term aerobic exercise increases redox-active iron through nitric oxide in rat hippocampus. Nitric Oxide 36 1-10 PubMed GONUTS page

[PMID:23994517-17] DeRuisseau, KC et al. (2013) Aging-related changes in the iron status of skeletal muscle. Exp. Gerontol. 48 1294-302 PubMed GONUTS page

[PMID:24024381-18] Yang, L et al. (2013) [Effects of different zinc nutritional status on iron metabolism in rats]. Wei Sheng Yan Jiu 42 647-51 PubMed GONUTS page

[PMID:21753061-19] 19.0 ^19.1 ^19.2 Davis, MR et al. (2011) Hypoxia inducible factor-2 α is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats. J. Nutr. 141 1590-6 PubMed GONUTS page

[PMID:19943190-20] 20.0 ^20.1 Dornelles, AS et al. (2010) mRNA expression of proteins involved in iron homeostasis in brain regions is altered by age and by iron overloading in the neonatal period. Neurochem. Res. 35 564-71 PubMed GONUTS page

[PMID:21873635-21] 21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 ^21.11 ^21.12 ^21.13 ^21.14 ^21.15 ^21.16 ^21.17 ^21.18 ^21.19 ^21.20 ^21.21 ^21.22 ^21.23 ^21.24 ^21.25 ^21.26 ^21.27 ^21.28 ^21.29 ^21.30 ^21.31 ^21.32 ^21.33 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:IREB2

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