RAT:GSK3B

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Gsk3b
Protein Name(s)	Glycogen synthase kinase-3 beta GSK-3 beta Factor A FA Serine/threonine-protein kinase GSK3B
External Links
UniProt	P18266
EMBL	X53428 X73653
PIR	S14708
RefSeq	NP_114469.1
UniGene	Rn.10426
ProteinModelPortal	P18266
SMR	P18266
BioGrid	249893
DIP	DIP-40957N
IntAct	P18266
MINT	MINT-121872
STRING	10116.ENSRNOP00000003867
BindingDB	P18266
ChEMBL	CHEMBL3669
iPTMnet	P18266
PhosphoSite	P18266
PaxDb	P18266
PRIDE	P18266
GeneID	84027
KEGG	rno:84027
UCSC	RGD:70982
CTD	2932
RGD	70982
eggNOG	KOG0658 COG0515
HOGENOM	HOG000233017
HOVERGEN	HBG014652
InParanoid	P18266
KO	K03083
OrthoDB	EOG7TF78V
PhylomeDB	P18266
TreeFam	TF101104
BRENDA	2.7.11.26
NextBio	616603
PRO	PR:P18266
Proteomes	UP000002494
GO	GO:0030424 GO:0030877 GO:0005737 GO:0005829 GO:0030425 GO:0043197 GO:0016020 GO:0045121 GO:0005874 GO:0005739 GO:0005634 GO:0005886 GO:0043234 GO:0005524 GO:0005178 GO:0035255 GO:0016301 GO:0019901 GO:0004674 GO:0048156 GO:0050321 GO:0008134 GO:0007568 GO:1903351 GO:0036018 GO:0070301 GO:0036016 GO:0071282 GO:0071285 GO:0071260 GO:0007623 GO:0001837 GO:0030010 GO:0007163 GO:0097192 GO:0005977 GO:2000171 GO:0050774 GO:1904339 GO:0043407 GO:2001223 GO:0051534 GO:0051001 GO:1900181 GO:0034392 GO:0018105 GO:0043065 GO:2000573 GO:2000463 GO:0010918 GO:1901030 GO:0043525 GO:0032092 GO:0045732 GO:0048661 GO:0006468 GO:0030516 GO:0050770 GO:0048814 GO:0032886 GO:0048168 GO:0014823 GO:1990776 GO:0042493 GO:0071871 GO:0032355 GO:0032868 GO:1990418 GO:1902065 GO:0010226 GO:1990478 GO:0016055
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	PMID:25764078^[1]	ECO:0000315			P		The nature of regulation is age dependent. In figure 6B,C Inhibition of GSK3 by AR and SB resulted in an increase in synapse density for older cultures (21 DIV). Younger Cultures had an inverse response.	complete CACAO 11247
	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	PMID:25764078^[1]	ECO:0000315			P		The nature of regulation is age dependent. In figure 6D, Inhibition of GSK3 by AR and SB resulted in an decrease in synapse density for younger cultures (12 DIV).	complete CACAO 11248
enables	GO:0004672	protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
involved_in	GO:1901984	negative regulation of protein acetylation	PMID:18268107^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002608) regulates_o_occurs_in:(GO:0015630)	Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:18268107^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(GO:0030424) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:26224839^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	causally_upstream_of:(GO:0071902) occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1900181	negative regulation of protein localization to nucleus	PMID:23624080^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	transports_or_maintains_localization_of:(UniProtKB:P46153) part_of:(GO:0003300)	Seeded From UniProt	complete
involved_in	GO:0030011	maintenance of cell polarity	PMID:15652487^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0106027	neuron projection organization	PMID:15652487^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	PMID:15652487^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:10228155^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11035810^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11035810^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9482734^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
involved_in	GO:0036016	cellular response to interleukin-3	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0032886	regulation of microtubule-based process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16815997^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
involved_in	GO:0099159	regulation of modification of postsynaptic structure	PMID:23864697^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099159	regulation of modification of postsynaptic structure	PMID:23864697^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
involved_in	GO:0099159	regulation of modification of postsynaptic structure	PMID:23864697^[10]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099159	regulation of modification of postsynaptic structure	PMID:23864697^[10]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
involved_in	GO:0099159	regulation of modification of postsynaptic structure	PMID:23864697^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099159	regulation of modification of postsynaptic structure	PMID:23864697^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
involved_in	GO:0099159	regulation of modification of postsynaptic structure	PMID:23864697^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099159	regulation of modification of postsynaptic structure	PMID:23864697^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:23864697^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:23864697^[10]	ECO:0006052	RNAi evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:23864697^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:23864697^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:23864697^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:23864697^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:23864697^[10]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:23864697^[10]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:23864697^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:23864697^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:23864697^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	PMID:23864697^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:23864697^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:23864697^[10]	ECO:0006052	RNAi evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:23864697^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:23864697^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001223	negative regulation of neuron migration	PMID:11403684^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	PMID:12721208^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:20007479^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000171	negative regulation of dendrite development	PMID:23470087^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990776	response to angiotensin	PMID:22982863^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990478	response to ultrasound	PMID:20708505^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990418	response to insulin-like growth factor stimulus	PMID:17686886^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904339	negative regulation of dopaminergic neuron differentiation	PMID:15522889^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	PMID:20007479^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902065	response to L-glutamate	PMID:18445133^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097284	hepatocyte apoptotic process	PMID:28638224^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090290	positive regulation of osteoclast proliferation	PMID:26722385^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071871	response to epinephrine	PMID:16934435^[22]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071285	cellular response to lithium ion	PMID:18932008^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071282	cellular response to iron(II) ion	PMID:19608791^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:20042609^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:18005341^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061049	cell growth involved in cardiac muscle cell development	PMID:27854077^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051001	negative regulation of nitric-oxide synthase activity	PMID:18005341^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050774	negative regulation of dendrite morphogenesis	PMID:17182785^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050770	regulation of axonogenesis	PMID:15652487^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:16735023^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:15652487^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:21557011^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	PMID:17329210^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:16735023^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	PMID:29224185^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:17686886^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	PMID:28731198^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045667	regulation of osteoblast differentiation	PMID:28731198^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:16735023^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:20841359^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:16765055^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	PMID:17182785^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:17329210^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:12808104^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:12393899^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:19359144^[38]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036018	cellular response to erythropoietin	PMID:17952604^[39]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035733	hepatic stellate cell activation	PMID:28061416^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:17329210^[31]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621531	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:17329210^[31]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:61862	F		Seeded From UniProt	complete
involved_in	GO:0034392	negative regulation of smooth muscle cell apoptotic process	PMID:21557011^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033690	positive regulation of osteoblast proliferation	PMID:26722385^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17329210^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:16934435^[22]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:22252247^[41]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030516	regulation of axon extension	PMID:15652487^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:15652487^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:15652487^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	PMID:12610628^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20841359^[34]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2262	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:16478782^[43]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620632	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:1346104^[44]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	PMID:22252247^[41]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010918	positive regulation of mitochondrial membrane potential	PMID:19318234^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010226	response to lithium ion	PMID:20926980^[46]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010226	response to lithium ion	PMID:19359144^[38]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010043	response to zinc ion	PMID:27295130^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18367454^[48]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:728892	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:16041621^[49]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007163	establishment or maintenance of cell polarity	PMID:12610628^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:17329210^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16879317^[50]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:8576078^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17329210^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19755525^[52]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18367454^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18367454^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:17329210^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:16879317^[50]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:18677563^[53]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2927	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:2164470^[54]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:17329210^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16879317^[50]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR033573	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.26	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-RNO-198601	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0321	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Cuesto, G et al. (2015) GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS ONE 10 e0118475 PubMed GONUTS page
↑ ^2.0 ^2.1 Witte, H et al. (2008) Microtubule stabilization specifies initial neuronal polarization. J. Cell Biol. 180 619-32 PubMed GONUTS page
↑ Ohnishi, T et al. (2015) Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc. Natl. Acad. Sci. U.S.A. 112 E4465-74 PubMed GONUTS page
↑ Li, R et al. (2013) miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. FEBS Lett. 587 1754-61 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Jiang, H et al. (2005) Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators. Cell 120 123-35 PubMed GONUTS page
↑ Kitagawa, M et al. (1999) An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J. 18 2401-10 PubMed GONUTS page
↑ ^7.0 ^7.1 Fang, X et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. U.S.A. 97 11960-5 PubMed GONUTS page
↑ Ikeda, S et al. (1998) Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J. 17 1371-84 PubMed GONUTS page
↑ Chen, HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 20 1933-45 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 ^10.21 ^10.22 ^10.23 Nelson, CD et al. (2013) Phosphorylation of threonine-19 of PSD-95 by GSK-3β is required for PSD-95 mobilization and long-term depression. J. Neurosci. 33 12122-35 PubMed GONUTS page
↑ Tong, N et al. (2001) Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. Eur. J. Neurosci. 13 1913-22 PubMed GONUTS page
↑ Guo, TB et al. () Evidence for a role of glycogen synthase kinase-3 beta in rodent spermatogenesis. J. Androl. 24 332-42 PubMed GONUTS page
↑ ^13.0 ^13.1 Li, YC et al. (2009) Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J. Neurosci. 29 15551-63 PubMed GONUTS page
↑ Tan, M et al. (2013) GSK-3α/β-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth. J. Neurochem. 125 685-97 PubMed GONUTS page
↑ Tian, M et al. (2012) Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. FEBS Lett. 586 3737-45 PubMed GONUTS page
↑ Ren, C et al. (2010) LIPUS enhance elongation of neurites in rat cortical neurons through inhibition of GSK-3beta. Biomed. Environ. Sci. 23 244-9 PubMed GONUTS page
↑ ^17.0 ^17.1 Fang, CH et al. (2007) GSK-3beta activity is increased in skeletal muscle after burn injury in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 R1545-51 PubMed GONUTS page
↑ Castelo-Branco, G et al. (2004) GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons. J. Cell. Sci. 117 5731-7 PubMed GONUTS page
↑ Lee, JH et al. (2008) Concomitant degradation of beta-catenin and GSK-3 beta potently contributes to glutamate-induced neurotoxicity in rat hippocampal slice cultures. J. Neurochem. 106 1066-77 PubMed GONUTS page
↑ Zhang, X et al. (2017) Inhibitory effect of oxymatrine on hepatocyte apoptosis TLR4/PI3K/Akt/GSK-3β signaling pathway. World J. Gastroenterol. 23 3839-3849 PubMed GONUTS page
↑ ^21.0 ^21.1 Qi, J et al. (2015) Roles of TNF-α, GSK-3β and RANKL in the occurrence and development of diabetic osteoporosis. Int J Clin Exp Pathol 8 11995-2004 PubMed GONUTS page
↑ ^22.0 ^22.1 Jensen, J et al. (2007) GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3. Cell. Signal. 19 204-10 PubMed GONUTS page
↑ Mendes, CT et al. (2009) Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease. Eur Arch Psychiatry Clin Neurosci 259 16-22 PubMed GONUTS page
↑ Uranga, RM et al. (2009) Iron-induced oxidative injury differentially regulates PI3K/Akt/GSK3beta pathway in synaptic endings from adult and aged rats. Toxicol. Sci. 111 331-44 PubMed GONUTS page
↑ Sunters, A et al. (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. J. Biol. Chem. 285 8743-58 PubMed GONUTS page
↑ ^26.0 ^26.1 Yu, Y et al. (2008) Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3 beta and a receptor-independent anti-oxidative action. J. Neurochem. 104 946-56 PubMed GONUTS page
↑ Chowdhury, D et al. (2017) Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3β signaling. Mol. Cell. Biochem. 425 155-168 PubMed GONUTS page
↑ ^28.0 ^28.1 Naska, S et al. (2006) An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth. J. Neurosci. 26 13344-56 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Sui, Z et al. (2006) Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts. Biochem. Biophys. Res. Commun. 345 1643-8 PubMed GONUTS page
↑ ^30.0 ^30.1 Guha, S et al. (2011) Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival. Basic Res. Cardiol. 106 773-85 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 ^31.3 ^31.4 ^31.5 ^31.6 ^31.7 ^31.8 Peineau, S et al. (2007) LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53 703-17 PubMed GONUTS page
↑ Mao, Y et al. (2018) Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3β/β-catenin signaling pathway. J. Mol. Histol. 49 75-84 PubMed GONUTS page
↑ ^33.0 ^33.1 Amirhosseini, M et al. (2018) GSK-3β inhibition suppresses instability-induced osteolysis by a dual action on osteoblast and osteoclast differentiation. J. Cell. Physiol. 233 2398-2408 PubMed GONUTS page
↑ ^34.0 ^34.1 Song, B et al. (2010) Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. J. Biol. Chem. 285 41122-34 PubMed GONUTS page
↑ Brewster, JL et al. (2006) Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neurons. Mol. Cell. Neurosci. 32 242-53 PubMed GONUTS page
↑ Sanchez, JF et al. (2003) Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling. Mol. Cell. Biol. 23 4649-62 PubMed GONUTS page
↑ Hetman, M et al. (2002) ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. J. Biol. Chem. 277 49577-84 PubMed GONUTS page
↑ ^38.0 ^38.1 Fatemi, SH et al. (2009) Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats. Schizophr. Res. 111 138-52 PubMed GONUTS page
↑ Shang, Y et al. (2007) Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons: involvement of PI3K/Akt and GSK-3 beta pathway. Apoptosis 12 2187-95 PubMed GONUTS page
↑ Wu, X et al. (2017) Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway. Int. Immunopharmacol. 43 164-171 PubMed GONUTS page
↑ ^41.0 ^41.1 Bu, S et al. (2012) Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats. Eur. J. Appl. Physiol. 112 3295-304 PubMed GONUTS page
↑ ^42.0 ^42.1 Etienne-Manneville, S & Hall, A (2003) Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 421 753-6 PubMed GONUTS page
↑ Aschenbach, WG et al. (2006) Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Am. J. Physiol. Endocrinol. Metab. 291 E152-8 PubMed GONUTS page
↑ Hughes, K et al. (1992) Baculovirus-mediated expression and characterisation of rat glycogen synthase kinase-3 beta, the mammalian homologue of the Drosophila melanogaster zeste-white 3sgg homeotic gene product. Eur. J. Biochem. 203 305-11 PubMed GONUTS page
↑ Javadov, S et al. (2009) Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction. J. Mol. Cell. Cardiol. 46 998-1007 PubMed GONUTS page
↑ Bertsch, S et al. (2011) Inhibition of glycogen synthase kinase 3[beta] activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnover. Shock 35 266-74 PubMed GONUTS page
↑ Wu, Y et al. (2016) Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of Akt-GLUT4, GSK3β and mTOR-S6K1. J. Nutr. Biochem. 34 126-35 PubMed GONUTS page
↑ ^48.0 ^48.1 ^48.2 Zhou, F et al. (2008) The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J. Biol. Chem. 283 14506-15 PubMed GONUTS page
↑ Kinnard, RS et al. (2005) Regulation of p70S6k, GSK-3beta, and calcineurin in rat striated muscle during aging. Biogerontology 6 173-84 PubMed GONUTS page
↑ ^50.0 ^50.1 ^50.2 Yin, J et al. (2006) Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain. J. Pineal Res. 41 124-9 PubMed GONUTS page
↑ Hoshi, M et al. (1995) Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondria. J. Biochem. 118 683-5 PubMed GONUTS page
↑ Miki, T et al. (2009) Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition. Diabetes 58 2863-72 PubMed GONUTS page
↑ Cortés, JC et al. (2009) Dp71f modulates GSK3-beta recruitment to the beta1-integrin adhesion complex. Neurochem. Res. 34 438-44 PubMed GONUTS page
↑ Woodgett, JR (1990) Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J. 9 2431-8 PubMed GONUTS page

[PMID:25764078-1] 1.0 ^1.1 Cuesto, G et al. (2015) GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS ONE 10 e0118475 PubMed GONUTS page

[PMID:18268107-2] 2.0 ^2.1 Witte, H et al. (2008) Microtubule stabilization specifies initial neuronal polarization. J. Cell Biol. 180 619-32 PubMed GONUTS page

[PMID:26224839-3] Ohnishi, T et al. (2015) Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc. Natl. Acad. Sci. U.S.A. 112 E4465-74 PubMed GONUTS page

[PMID:23624080-4] Li, R et al. (2013) miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. FEBS Lett. 587 1754-61 PubMed GONUTS page

[PMID:15652487-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Jiang, H et al. (2005) Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators. Cell 120 123-35 PubMed GONUTS page

[PMID:10228155-6] Kitagawa, M et al. (1999) An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J. 18 2401-10 PubMed GONUTS page

[PMID:11035810-7] 7.0 ^7.1 Fang, X et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. U.S.A. 97 11960-5 PubMed GONUTS page

[PMID:9482734-8] Ikeda, S et al. (1998) Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J. 17 1371-84 PubMed GONUTS page

[PMID:16815997-9] Chen, HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 20 1933-45 PubMed GONUTS page

[PMID:23864697-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 ^10.21 ^10.22 ^10.23 Nelson, CD et al. (2013) Phosphorylation of threonine-19 of PSD-95 by GSK-3β is required for PSD-95 mobilization and long-term depression. J. Neurosci. 33 12122-35 PubMed GONUTS page

[PMID:11403684-11] Tong, N et al. (2001) Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. Eur. J. Neurosci. 13 1913-22 PubMed GONUTS page

[PMID:12721208-12] Guo, TB et al. () Evidence for a role of glycogen synthase kinase-3 beta in rodent spermatogenesis. J. Androl. 24 332-42 PubMed GONUTS page

[PMID:20007479-13] 13.0 ^13.1 Li, YC et al. (2009) Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J. Neurosci. 29 15551-63 PubMed GONUTS page

[PMID:23470087-14] Tan, M et al. (2013) GSK-3α/β-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth. J. Neurochem. 125 685-97 PubMed GONUTS page

[PMID:22982863-15] Tian, M et al. (2012) Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. FEBS Lett. 586 3737-45 PubMed GONUTS page

[PMID:20708505-16] Ren, C et al. (2010) LIPUS enhance elongation of neurites in rat cortical neurons through inhibition of GSK-3beta. Biomed. Environ. Sci. 23 244-9 PubMed GONUTS page

[PMID:17686886-17] 17.0 ^17.1 Fang, CH et al. (2007) GSK-3beta activity is increased in skeletal muscle after burn injury in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 R1545-51 PubMed GONUTS page

[PMID:15522889-18] Castelo-Branco, G et al. (2004) GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons. J. Cell. Sci. 117 5731-7 PubMed GONUTS page

[PMID:18445133-19] Lee, JH et al. (2008) Concomitant degradation of beta-catenin and GSK-3 beta potently contributes to glutamate-induced neurotoxicity in rat hippocampal slice cultures. J. Neurochem. 106 1066-77 PubMed GONUTS page

[PMID:28638224-20] Zhang, X et al. (2017) Inhibitory effect of oxymatrine on hepatocyte apoptosis TLR4/PI3K/Akt/GSK-3β signaling pathway. World J. Gastroenterol. 23 3839-3849 PubMed GONUTS page

[PMID:26722385-21] 21.0 ^21.1 Qi, J et al. (2015) Roles of TNF-α, GSK-3β and RANKL in the occurrence and development of diabetic osteoporosis. Int J Clin Exp Pathol 8 11995-2004 PubMed GONUTS page

[PMID:16934435-22] 22.0 ^22.1 Jensen, J et al. (2007) GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3. Cell. Signal. 19 204-10 PubMed GONUTS page

[PMID:18932008-23] Mendes, CT et al. (2009) Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease. Eur Arch Psychiatry Clin Neurosci 259 16-22 PubMed GONUTS page

[PMID:19608791-24] Uranga, RM et al. (2009) Iron-induced oxidative injury differentially regulates PI3K/Akt/GSK3beta pathway in synaptic endings from adult and aged rats. Toxicol. Sci. 111 331-44 PubMed GONUTS page

[PMID:20042609-25] Sunters, A et al. (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. J. Biol. Chem. 285 8743-58 PubMed GONUTS page

[PMID:18005341-26] 26.0 ^26.1 Yu, Y et al. (2008) Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3 beta and a receptor-independent anti-oxidative action. J. Neurochem. 104 946-56 PubMed GONUTS page

[PMID:27854077-27] Chowdhury, D et al. (2017) Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3β signaling. Mol. Cell. Biochem. 425 155-168 PubMed GONUTS page

[PMID:17182785-28] 28.0 ^28.1 Naska, S et al. (2006) An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth. J. Neurosci. 26 13344-56 PubMed GONUTS page

[PMID:16735023-29] 29.0 ^29.1 ^29.2 Sui, Z et al. (2006) Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts. Biochem. Biophys. Res. Commun. 345 1643-8 PubMed GONUTS page

[PMID:21557011-30] 30.0 ^30.1 Guha, S et al. (2011) Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival. Basic Res. Cardiol. 106 773-85 PubMed GONUTS page

[PMID:17329210-31] 31.0 ^31.1 ^31.2 ^31.3 ^31.4 ^31.5 ^31.6 ^31.7 ^31.8 Peineau, S et al. (2007) LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53 703-17 PubMed GONUTS page

[PMID:29224185-32] Mao, Y et al. (2018) Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3β/β-catenin signaling pathway. J. Mol. Histol. 49 75-84 PubMed GONUTS page

[PMID:28731198-33] 33.0 ^33.1 Amirhosseini, M et al. (2018) GSK-3β inhibition suppresses instability-induced osteolysis by a dual action on osteoblast and osteoclast differentiation. J. Cell. Physiol. 233 2398-2408 PubMed GONUTS page

[PMID:20841359-34] 34.0 ^34.1 Song, B et al. (2010) Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. J. Biol. Chem. 285 41122-34 PubMed GONUTS page

[PMID:16765055-35] Brewster, JL et al. (2006) Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neurons. Mol. Cell. Neurosci. 32 242-53 PubMed GONUTS page

[PMID:12808104-36] Sanchez, JF et al. (2003) Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling. Mol. Cell. Biol. 23 4649-62 PubMed GONUTS page

[PMID:12393899-37] Hetman, M et al. (2002) ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. J. Biol. Chem. 277 49577-84 PubMed GONUTS page

[PMID:19359144-38] 38.0 ^38.1 Fatemi, SH et al. (2009) Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats. Schizophr. Res. 111 138-52 PubMed GONUTS page

[PMID:17952604-39] Shang, Y et al. (2007) Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons: involvement of PI3K/Akt and GSK-3 beta pathway. Apoptosis 12 2187-95 PubMed GONUTS page

[PMID:28061416-40] Wu, X et al. (2017) Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway. Int. Immunopharmacol. 43 164-171 PubMed GONUTS page

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[PMID:16478782-43] Aschenbach, WG et al. (2006) Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Am. J. Physiol. Endocrinol. Metab. 291 E152-8 PubMed GONUTS page

[PMID:1346104-44] Hughes, K et al. (1992) Baculovirus-mediated expression and characterisation of rat glycogen synthase kinase-3 beta, the mammalian homologue of the Drosophila melanogaster zeste-white 3sgg homeotic gene product. Eur. J. Biochem. 203 305-11 PubMed GONUTS page

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RAT:GSK3B

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