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RAT:GPX1

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Gpx1
Protein Name(s) Glutathione peroxidase 1

GPx-1 GSHPx-1 Cellular glutathione peroxidase

External Links
UniProt P04041
EMBL M21210
X07365
X12367
S50336
S41066
AB004231
PIR A30793
RefSeq NP_110453.3
UniGene Rn.11323
ProteinModelPortal P04041
MINT MINT-4564335
PeroxiBase 3730
PhosphoSite P04041
PRIDE P04041
GeneID 24404
KEGG rno:24404
CTD 2876
RGD 2729
HOVERGEN HBG004333
InParanoid P04041
KO K00432
PhylomeDB P04041
Reactome REACT_197256
REACT_198843
REACT_213899
REACT_215233
NextBio 603207
Proteomes UP000002494
ExpressionAtlas P04041
Genevestigator P04041
GO GO:0005829
GO:0070062
GO:0005739
GO:0005634
GO:0043295
GO:0004602
GO:0047066
GO:0008430
GO:0007568
GO:0060055
GO:0043534
GO:0045454
GO:0001885
GO:0045444
GO:0006749
GO:0060047
GO:0042744
GO:0051702
GO:0008631
GO:0051450
GO:0043154
GO:1902042
GO:0002862
GO:1902176
GO:0090201
GO:0051897
GO:0018158
GO:0040029
GO:0033599
GO:0043523
GO:0061136
GO:0032355
GO:0051593
GO:0010332
GO:0009749
GO:0009725
GO:0006982
GO:0035094
GO:0014070
GO:0006979
GO:0010269
GO:0009609
GO:0009636
GO:0009410
GO:0007605
GO:0048741
GO:0043403
GO:0001659
GO:0006641
GO:0009650
GO:0042311
Gene3D 3.40.30.10
InterPro IPR000889
IPR029759
IPR029760
IPR012336
PANTHER PTHR11592
Pfam PF00255
PIRSF PIRSF000303
PRINTS PR01011
SUPFAM SSF52833
PROSITE PS00460
PS00763
PS51355

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071333

cellular response to glucose stimulus

PMID:19944066[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051593

response to folic acid

PMID:16251605[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042744

hydrogen peroxide catabolic process

PMID:16140890[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035094

response to nicotine

PMID:18343235[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

PMID:17211248[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

PMID:18255150[6]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010269

response to selenium ion

PMID:19234057[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009749

response to glucose

PMID:15039483[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009725

response to hormone

PMID:17561443[9]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

PMID:17021340[10]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006749

glutathione metabolic process

PMID:16140890[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:1640255[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:19914224[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12516874[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004602

glutathione peroxidase activity

PMID:1640255[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004602

glutathione peroxidase activity

PMID:16140890[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042744

hydrogen peroxide catabolic process

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104887
PANTHER:PTN002613004
RGD:2729
UniProtKB:P00435
UniProtKB:P07203

P

Seeded From UniProt

complete

involved_in

GO:0042542

response to hydrogen peroxide

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104887
PANTHER:PTN002613004
UniProtKB:P07203

P

Seeded From UniProt

complete

involved_in

GO:0010269

response to selenium ion

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002613004
RGD:2729
UniProtKB:P07203

P

Seeded From UniProt

complete

involved_in

GO:0006749

glutathione metabolic process

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002613004
RGD:2729
UniProtKB:P00435
UniProtKB:P07203

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002613004
RGD:2729
UniProtKB:P07203

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104887
PANTHER:PTN002613004
RGD:2729
UniProtKB:P07203

C

Seeded From UniProt

complete

enables

GO:0004602

glutathione peroxidase activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104887
MGI:MGI:105102
MGI:MGI:106609
PANTHER:PTN000904512
RGD:2729
RGD:69224
RGD:727780
UniProtKB:P00435
UniProtKB:P07203
UniProtKB:P22352

F

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10129
FB:FBgn0035438
MGI:MGI:104767
MGI:MGI:104887
MGI:MGI:105102
MGI:MGI:106609
PANTHER:PTN000173826
RGD:2729
RGD:69224
RGD:69226
RGD:727780
SGD:S000000448
SGD:S000001476
SGD:S000001509
TAIR:locus:2031331
UniProtKB:P00435
UniProtKB:P07203
UniProtKB:P22352
UniProtKB:P36969
UniProtKB:P83564
UniProtKB:Q6JAH6
UniProtKB:Q8I5T2
UniProtKB:Q8TED1
UniProtKB:Q96SL4

F

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004602

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004602

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004602

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004602

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004602

P

Seeded From UniProt

complete

enables

GO:0004602

glutathione peroxidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000889

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000889

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000889

P

Seeded From UniProt

complete

enables

GO:0004602

glutathione peroxidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.11.1.9

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0575

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Yang, WH et al. (2010) O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation. Biochem. Biophys. Res. Commun. 391 756-61 PubMed GONUTS page
  2. ↑ Chanson, A et al. (2005) Proteomic analysis reveals changes in the liver protein pattern of rats exposed to dietary folate deficiency. J. Nutr. 135 2524-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Sunde, RA et al. (2005) Dietary selenium requirements based on glutathione peroxidase-1 activity and mRNA levels and other Se-dependent parameters are not increased by pregnancy and lactation in rats. J. Nutr. 135 2144-50 PubMed GONUTS page
  4. ↑ Bruin, JE et al. (2008) Maternal nicotine exposure increases oxidative stress in the offspring. Free Radic. Biol. Med. 44 1919-25 PubMed GONUTS page
  5. ↑ Zhang, L et al. (2007) Effect of oestrogen on reactive oxygen species production in the aortas of ovariectomized Dahl salt-sensitive rats. J. Hypertens. 25 407-14 PubMed GONUTS page
  6. ↑ Yeste-Velasco, M et al. (2008) DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons. Neurotoxicology 29 309-17 PubMed GONUTS page
  7. ↑ Schriever, SC et al. (2009) Selenium requirements are higher for glutathione peroxidase-1 mRNA than gpx1 activity in rat testis. Exp. Biol. Med. (Maywood) 234 513-21 PubMed GONUTS page
  8. ↑ Morrison, J et al. (2004) Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response. Physiol. Genomics 17 271-82 PubMed GONUTS page
  9. ↑ Chattopadhyay, S et al. (2007) Differential expression profiles of antioxidant enzymes and glutathione redox status in hyperthyroid rats: a temporal analysis. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 146 383-91 PubMed GONUTS page
  10. ↑ Weir, CP & Robaire, B () Spermatozoa have decreased antioxidant enzymatic capacity and increased reactive oxygen species production during aging in the Brown Norway rat. J. Androl. 28 229-40 PubMed GONUTS page
  11. ↑ 11.0 11.1 Christensen, MJ & Burgener, KW (1992) Dietary selenium stabilizes glutathione peroxidase mRNA in rat liver. J. Nutr. 122 1620-6 PubMed GONUTS page
  12. ↑ Subudhi, U & Chainy, GB (2010) Expression of hepatic antioxidant genes in l-thyroxine-induced hyperthyroid rats: regulation by vitamin E and curcumin. Chem. Biol. Interact. 183 304-16 PubMed GONUTS page
  13. ↑ Fujii, T et al. (2002) Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys. Free Radic. Res. 36 1041-9 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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