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RAT:GCKR

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Gckr
Protein Name(s) Glucokinase regulatory protein

Glucokinase regulator

External Links
UniProt Q07071
EMBL X68497
BC081843
PIR S41745
RefSeq NP_037252.1
UniGene Rn.7863
PDB 4LC9
PDBsum 4LC9
ProteinModelPortal Q07071
IntAct Q07071
MINT MINT-1795091
BindingDB Q07071
ChEMBL CHEMBL3124733
PRIDE Q07071
Ensembl ENSRNOT00000073228
GeneID 25658
KEGG rno:25658
CTD 2646
RGD 2671
GeneTree ENSGT00390000005345
HOVERGEN HBG005818
InParanoid Q07071
OMA QHVIETP
OrthoDB EOG7HXCRC
PhylomeDB Q07071
Reactome REACT_251652
SABIO-RK Q07071
NextBio 607553
PRO PR:Q07071
Proteomes UP000002494
Genevestigator Q07071
GO GO:0005737
GO:0005829
GO:0005739
GO:0005654
GO:0005634
GO:0030246
GO:0019899
GO:0004857
GO:0070095
GO:0019904
GO:0001678
GO:0051594
GO:0006006
GO:0043086
GO:0033132
GO:0033133
GO:0000060
GO:0009750
GO:0070328
GO:0046415
InterPro IPR005486
IPR001347
PROSITE PS01272
PS51464

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051594

detection of glucose

PMID:19807849[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033132

negative regulation of glucokinase activity

PMID:14627435[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009750

response to fructose

PMID:14627435[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10601273[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10601273[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006606

protein import into nucleus

PMID:10601273[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070095

fructose-6-phosphate binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14397

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10518020[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:10518020[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1903300

negative regulation of hexokinase activity

PMID:14627435[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

PMID:11756407[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

PMID:14627435[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:16186382[6]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:2670

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:16186382[6]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:2670

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:11756407[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16542652[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:16542652[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15138155[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16186382[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15138155[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004857

enzyme inhibitor activity

PMID:14627435[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004857

enzyme inhibitor activity

PMID:11756407[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070095

fructose-6-phosphate binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001297103
UniProtKB:Q14397

F

Seeded From UniProt

complete

involved_in

GO:0042593

glucose homeostasis

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001297103
ZFIN:ZDB-GENE-110411-248

P

Seeded From UniProt

complete

involved_in

GO:0033132

negative regulation of glucokinase activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096345
PANTHER:PTN001297103
RGD:2671
UniProtKB:Q14397

P

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001297103
RGD:2671

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001297103
RGD:2671

F

Seeded From UniProt

complete

involved_in

GO:0009750

response to fructose

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001297103
RGD:2671
UniProtKB:Q14397

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001297103
RGD:2671

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001297103
RGD:2671

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001297103
RGD:2671

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096345
PANTHER:PTN001297103
RGD:2671

C

Seeded From UniProt

complete

enables

GO:0004857

enzyme inhibitor activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001297103
RGD:2671

F

Seeded From UniProt

complete

involved_in

GO:0034504

protein localization to nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X44
ensembl:ENSMUSP00000072084

P

Seeded From UniProt

complete

involved_in

GO:0033133

positive regulation of glucokinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X44
ensembl:ENSMUSP00000072084

P

Seeded From UniProt

complete

involved_in

GO:0033132

negative regulation of glucokinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X44
ensembl:ENSMUSP00000072084

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X44
ensembl:ENSMUSP00000072084

C

Seeded From UniProt

complete

involved_in

GO:0001678

cellular glucose homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X44
ensembl:ENSMUSP00000072084

P

Seeded From UniProt

complete

enables

GO:0097367

carbohydrate derivative binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001347

F

Seeded From UniProt

complete

involved_in

GO:1901135

carbohydrate derivative metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001347

P

Seeded From UniProt

complete

involved_in

GO:0006006

glucose metabolic process

PMID:11756407[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Roncero, I et al. (2009) Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain. J. Neuroendocrinol. 21 973-81 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Brocklehurst, KJ et al. (2004) Differences in regulatory properties between human and rat glucokinase regulatory protein. Biochem. J. 378 693-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Shiota, C et al. (1999) Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. J. Biol. Chem. 274 37125-30 PubMed GONUTS page
  4. ↑ 4.0 4.1 Fernández-Novell, JM et al. (1999) Intracellular distribution of hepatic glucokinase and glucokinase regulatory protein during the fasted to refed transition in rats. FEBS Lett. 459 211-4 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Veiga-da-Cunha, M & Van Schaftingen, E (2002) Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase. J. Biol. Chem. 277 8466-73 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Baltrusch, S et al. (2005) Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme. Diabetes 54 2829-37 PubMed GONUTS page
  7. ↑ 7.0 7.1 Arden, C et al. (2006) Glucokinase regulatory protein is associated with mitochondria in hepatocytes. FEBS Lett. 580 2065-70 PubMed GONUTS page
  8. ↑ 8.0 8.1 Fujimoto, Y et al. (2004) Defect in glucokinase translocation in Zucker diabetic fatty rats. Am. J. Physiol. Endocrinol. Metab. 287 E414-23 PubMed GONUTS page
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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