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RAT:EPN1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Epn1 | |
| Protein Name(s) | Epsin-1
EPS-15-interacting protein 1 | |
| External Links | ||
| UniProt | O88339 | |
| EMBL | AF018261 | |
| RefSeq | NP_476477.1 | |
| UniGene | Rn.30007 | |
| PDB | 1EDU 1EYH 1H0A 1KY6 | |
| PDBsum | 1EDU 1EYH 1H0A 1KY6 | |
| DisProt | DP00251 | |
| ProteinModelPortal | O88339 | |
| SMR | O88339 | |
| BioGrid | 250724 | |
| DIP | DIP-40738N | |
| IntAct | O88339 | |
| MINT | MINT-101104 | |
| STRING | 10116.ENSRNOP00000021286 | |
| iPTMnet | O88339 | |
| PhosphoSitePlus | O88339 | |
| PaxDb | O88339 | |
| PeptideAtlas | O88339 | |
| PRIDE | O88339 | |
| GeneID | 117277 | |
| KEGG | rno:117277 | |
| UCSC | RGD:619772 | |
| CTD | 29924 | |
| RGD | 619772 | |
| eggNOG | KOG2056 ENOG410XSM0 | |
| HOGENOM | HOG000008298 | |
| HOVERGEN | HBG006690 | |
| InParanoid | O88339 | |
| KO | K12471 | |
| OrthoDB | EOG091G0L45 | |
| PhylomeDB | O88339 | |
| EvolutionaryTrace | O88339 | |
| PRO | PR:O88339 | |
| Proteomes | UP000002494 | |
| Bgee | ENSRNOG00000015753 | |
| Genevisible | O88339 | |
| GO | GO:0005905 GO:0005737 GO:0031234 GO:0098890 GO:0098888 GO:0005634 GO:0098794 GO:0098793 GO:0043195 GO:0044325 GO:0008289 GO:0008134 GO:0006897 | |
| Gene3D | 1.25.40.90 | |
| InterPro | IPR013809 IPR008942 IPR003903 | |
| Pfam | PF01417 PF02809 | |
| SMART | SM00273 SM00726 | |
| SUPFAM | SSF48464 | |
| PROSITE | PS50942 PS50330 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0090148 |
membrane fission |
ECO:0000314 |
P |
Figure 2A-D reveal fission activity with addition of ENTH, for both 400 nm and 200 nm liposomes. Rattus norvegicus Epsin-1 (named ENTH in paper) |
complete | |||||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098793 |
presynapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002608) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098890 |
extrinsic component of postsynaptic membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098888 |
extrinsic component of presynaptic membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031234 |
extrinsic component of cytoplasmic side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0035615 |
clathrin adaptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1905445 |
positive regulation of clathrin coat assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043195 |
terminal bouton |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
part_of:(GO:0098685) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098685 |
Schaffer collateral - CA1 synapse |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:68398 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:727921 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006898 |
receptor-mediated endocytosis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0035615 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005905 |
clathrin-coated pit |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Brooks, A et al. (2015) Single particle fluorescence burst analysis of epsin induced membrane fission. PLoS ONE 10 e0119563 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Yao, PJ et al. (2006) Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy. J. Comp. Neurol. 494 368-79 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Kalthoff, C et al. (2002) Unusual structural organization of the endocytic proteins AP180 and epsin 1. J. Biol. Chem. 277 8209-16 PubMed GONUTS page
- ↑ Wilhelm, BG et al. (2014) Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science 344 1023-8 PubMed GONUTS page
- ↑ Piros, ET et al. (1999) Purification of an EH domain-binding protein from rat brain that modulates the gating of the rat ether-à-go-go channel. J. Biol. Chem. 274 33677-83 PubMed GONUTS page
- ↑ Hyman, J et al. (2000) Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). J. Cell Biol. 149 537-46 PubMed GONUTS page
- ↑ Ford, MG et al. (2002) Curvature of clathrin-coated pits driven by epsin. Nature 419 361-6 PubMed GONUTS page
- ↑ Liska, F et al. (2009) Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Dev. Dyn. 238 673-84 PubMed GONUTS page
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