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PMID:10791968
| Citation |
Hyman, J, Chen, H, Di Fiore, PP, De Camilli, P and Brunger, AT (2000) Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). J. Cell Biol. 149:537-46 |
|---|---|
| Abstract |
Epsin (Eps15 interactor) is a cytosolic protein involved in clathrin-mediated endocytosis via its direct interactions with clathrin, the clathrin adaptor AP-2, and Eps15. The NH(2)-terminal portion of epsin contains a phylogenetically conserved module of unknown function, known as the ENTH domain (epsin NH(2)-terminal homology domain). We have now solved the crystal structure of rat epsin 1 ENTH domain to 1.8 A resolution. This domain is structurally similar to armadillo and Heat repeats of beta-catenin and karyopherin-beta, respectively. We have also identified and characterized the interaction of epsin 1, via the ENTH domain, with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). Leptomycin B, an antifungal antibiotic, which inhibits the Crm1- dependent nuclear export pathway, induces an accumulation of epsin 1 in the nucleus. These findings suggest that epsin 1 may function in a signaling pathway connecting the endocytic machinery to the regulation of nuclear function. |
| Links | |
| Keywords |
Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Armadillo Domain Proteins; Calcium-Binding Proteins/metabolism; Carrier Proteins/chemistry; Carrier Proteins/metabolism; Cell Line; Cell Nucleus/metabolism; Crystallography, X-Ray; Cytoskeletal Proteins/chemistry; Cytosol/metabolism; DNA-Binding Proteins/metabolism; Drosophila Proteins; Fluorescent Antibody Technique; Insect Proteins/chemistry; Models, Molecular; Molecular Sequence Data; Neuropeptides/chemistry; Neuropeptides/metabolism; Phosphoproteins/metabolism; Protein Binding; Rats; Sequence Alignment; Trans-Activators; Transcription Factors/metabolism; Vesicular Transport Proteins; Zinc Fingers; beta Catenin |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0008134: transcription factor binding |
ECO:0000353: physical interaction evidence used in manual assertion |
RGD:727921 |
F |
Seeded From UniProt |
complete | ||
Notes
See also
References
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