RAT:DRD3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Drd3
Protein Name(s)	D(3) dopamine receptor Dopamine D3 receptor
External Links
UniProt	P19020
EMBL	X53944 M69194 M69189 M69190 M69191 M69192 M69193 S63847 S63846
PIR	S11565
RefSeq	NP_058836.1
UniGene	Rn.10356
ProteinModelPortal	P19020
STRING	10116.ENSRNOP00000031550
BindingDB	P19020
ChEMBL	CHEMBL3138
GuidetoPHARMACOLOGY	216
PhosphoSite	P19020
PaxDb	P19020
Ensembl	ENSRNOT00000029474
GeneID	29238
KEGG	rno:29238
UCSC	RGD:2521
CTD	1814
RGD	2521
eggNOG	NOG309657
GeneTree	ENSGT00770000120457
HOGENOM	HOG000239242
HOVERGEN	HBG106962
InParanoid	P19020
KO	K04146
OMA	LHPIRQF
OrthoDB	EOG769ZMG
PhylomeDB	P19020
TreeFam	TF334382
Reactome	REACT_232919 REACT_233455
NextBio	608506
PRO	PR:P19020
Proteomes	UP000002494
Genevestigator	P19020
GO	GO:0045177 GO:0042995 GO:0030139 GO:0005887 GO:0016020 GO:0005886 GO:0031748 GO:0035240 GO:0004952 GO:0001591 GO:0008144 GO:0019904 GO:0046717 GO:0007191 GO:0007195 GO:0050482 GO:0048148 GO:0006874 GO:0032922 GO:0007212 GO:0002031 GO:0007186 GO:0035483 GO:0007626 GO:0050883 GO:0007194 GO:0045776 GO:0060160 GO:0048715 GO:0051898 GO:0050709 GO:0032416 GO:0000122 GO:0008284 GO:0032467 GO:0060161 GO:0045840 GO:0035815 GO:0045944 GO:0060134 GO:0002016 GO:0030814 GO:0045187 GO:0014059 GO:0019216 GO:0040012 GO:0090325 GO:0040014 GO:0001975 GO:0042493 GO:0045471 GO:0034776 GO:0043278 GO:0001963 GO:0008542
InterPro	IPR001620 IPR000929 IPR000276 IPR017452
PANTHER	PTHR24249:SF38
Pfam	PF00001
PRINTS	PR00568 PR00242 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004952	dopamine neurotransmitter receptor activity	PMID:18424554^[1]	ECO:0000314			F		Figure two shows coimmunoprecipitation with dopamine receptor d1 in rat striatum.	complete CACAO 6591
involved_in	GO:0046717	acid secretion	PMID:8302280^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	PMID:8302280^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:1975644^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8302280^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:1975644^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:8302280^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	PMID:8302280^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	PMID:1975644^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:16510729^[4]	ECO:0006062	wide-field fluorescence microscopy evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:16510729^[4]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:16510729^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:16510729^[4]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:16510729^[4]	ECO:0000279	western blot evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:23001156^[5]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:16510729^[4]	ECO:0006062	wide-field fluorescence microscopy evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:16510729^[4]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:16510729^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:16510729^[4]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:16510729^[4]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:23001156^[5]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0090325	regulation of locomotion involved in locomotory behavior	PMID:22394078^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	PMID:16026479^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16902178^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045187	regulation of circadian sleep/wake cycle, sleep	PMID:15913875^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:9822449^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:25989500^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:15584906^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0040012	regulation of locomotion	PMID:15913875^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035815	positive regulation of renal sodium excretion	PMID:14621190^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035483	gastric emptying	PMID:18600456^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	PMID:16490190^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032416	negative regulation of sodium:proton antiporter activity	PMID:15265811^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	PMID:14732731^[17]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2518	F		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	PMID:14617818^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:14617818^[18]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:68338	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15584906^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:16490190^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007212	dopamine receptor signaling pathway	PMID:16490190^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:15265811^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:26649942^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14499480^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	PMID:16490190^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	PMID:14617818^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001963	synaptic transmission, dopaminergic	PMID:16490190^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16902178^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001205212 UniProtKB:P08588 UniProtKB:P18871	P		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94925 PANTHER:PTN001545416 RGD:2521 UniProtKB:P35462	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001545416 RGD:2521	P		Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001545416 RGD:2521	F		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94925 PANTHER:PTN001545416	P		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001545416 RGD:2521 UniProtKB:P35462	P		Seeded From UniProt	complete
involved_in	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664502 RGD:2520	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004514 FB:FBgn0035538 FB:FBgn0038541 FB:FBgn0038542 PANTHER:PTN000664502 UniProtKB:P07550 UniProtKB:P08913 UniProtKB:P14416 UniProtKB:P18825 UniProtKB:P18871 UniProtKB:P35462 WB:WBGene00004777	C		Seeded From UniProt	complete
enables	GO:0004935	adrenergic receptor activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87934 MGI:MGI:87935 PANTHER:PTN000664502	F		Seeded From UniProt	complete
involved_in	GO:0001963	synaptic transmission, dopaminergic	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001545416 RGD:2521	P		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94925 PANTHER:PTN001545416 RGD:2521 UniProtKB:P35462	F		Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	C		Seeded From UniProt	complete
involved_in	GO:0060161	positive regulation of dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0060160	negative regulation of dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0051580	regulation of neurotransmitter uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0050883	musculoskeletal movement, spinal reflex action	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0048715	negative regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	C		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	C		Seeded From UniProt	complete
involved_in	GO:0002016	regulation of blood volume by renin-angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	P		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30728 ensembl:ENSMUSP00000023390	F		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
involved_in	GO:0050482	arachidonic acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
involved_in	GO:0034776	response to histamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	F		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	C		Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	P		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35462 ensembl:ENSP00000373169	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001620	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001620	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001620	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:1975644^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007212	dopamine receptor signaling pathway	PMID:1975644^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	PMID:1975644^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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References

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↑ Fiorentini, C et al. (2008) Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Mol. Pharmacol. 74 59-69 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Chio, CL et al. (1994) Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors. Mol. Pharmacol. 45 51-60 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Sokoloff, P et al. (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347 146-51 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Chen, G et al. (2006) Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J. Neurosci. 26 2513-21 PubMed GONUTS page
↑ ^5.0 ^5.1 Sokoloff, P et al. (2013) Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia. Naunyn Schmiedebergs Arch. Pharmacol. 386 107-24 PubMed GONUTS page
↑ Fernandes, AR et al. (2012) Lentiviral-mediated gene delivery reveals distinct roles of nucleus accumbens dopamine D2 and D3 receptors in novelty- and light-induced locomotor activity. Eur. J. Neurosci. 35 1344-53 PubMed GONUTS page
↑ Bahi, A et al. (2005) Silencing dopamine D3-receptors in the nucleus accumbens shell in vivo induces changes in cocaine-induced hyperlocomotion. Eur. J. Neurosci. 21 3415-26 PubMed GONUTS page
↑ ^8.0 ^8.1 Zeng, C et al. (2006) Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Circ. Res. 99 494-500 PubMed GONUTS page
↑ ^9.0 ^9.1 Barik, S & de Beaurepaire, R (2005) Dopamine D3 modulation of locomotor activity and sleep in the nucleus accumbens and in lobules 9 and 10 of the cerebellum in the rat. Prog. Neuropsychopharmacol. Biol. Psychiatry 29 718-26 PubMed GONUTS page
↑ O'Connell, DP et al. (1998) Expression of the dopamine D3 receptor protein in the rat kidney. Hypertension 32 886-95 PubMed GONUTS page
↑ Wang, Z et al. (2015) Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Gα12. Transplantation 99 2274-84 PubMed GONUTS page
↑ ^12.0 ^12.1 Coronas, V et al. (2004) Dopamine D3 receptor stimulation promotes the proliferation of cells derived from the post-natal subventricular zone. J. Neurochem. 91 1292-301 PubMed GONUTS page
↑ Luippold, G et al. (2003) Dopamine D3 receptor mRNA and renal response to D3 receptor activation in spontaneously hypertensive rats. Hypertens. Res. 26 855-61 PubMed GONUTS page
↑ Kashyap, P et al. (2009) The D2/D3 agonist PD128907 (R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol) inhibits stimulated pyloric relaxation and spontaneous gastric emptying. Dig. Dis. Sci. 54 57-62 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Roberts, C et al. (2006) Dopamine D3 receptor modulation of dopamine efflux in the rat nucleus accumbens. Eur. J. Pharmacol. 534 108-14 PubMed GONUTS page
↑ ^16.0 ^16.1 Pedrosa, R et al. (2004) Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells. Br. J. Pharmacol. 142 1343-53 PubMed GONUTS page
↑ Zeng, C et al. (2004) Aberrant D1 and D3 dopamine receptor transregulation in hypertension. Hypertension 43 654-60 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Jeanneteau, F et al. (2004) Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Mol. Biol. Cell 15 696-705 PubMed GONUTS page
↑ Wang, JD et al. (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy 11 2057-2073 PubMed GONUTS page
↑ Griffon, N et al. (2003) CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Brain Res. Mol. Brain Res. 117 47-57 PubMed GONUTS page
↑ ^21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18424554-1] Fiorentini, C et al. (2008) Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Mol. Pharmacol. 74 59-69 PubMed GONUTS page

[PMID:8302280-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Chio, CL et al. (1994) Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors. Mol. Pharmacol. 45 51-60 PubMed GONUTS page

[PMID:1975644-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Sokoloff, P et al. (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347 146-51 PubMed GONUTS page

[PMID:16510729-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Chen, G et al. (2006) Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J. Neurosci. 26 2513-21 PubMed GONUTS page

[PMID:23001156-5] 5.0 ^5.1 Sokoloff, P et al. (2013) Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia. Naunyn Schmiedebergs Arch. Pharmacol. 386 107-24 PubMed GONUTS page

[PMID:22394078-6] Fernandes, AR et al. (2012) Lentiviral-mediated gene delivery reveals distinct roles of nucleus accumbens dopamine D2 and D3 receptors in novelty- and light-induced locomotor activity. Eur. J. Neurosci. 35 1344-53 PubMed GONUTS page

[PMID:16026479-7] Bahi, A et al. (2005) Silencing dopamine D3-receptors in the nucleus accumbens shell in vivo induces changes in cocaine-induced hyperlocomotion. Eur. J. Neurosci. 21 3415-26 PubMed GONUTS page

[PMID:16902178-8] 8.0 ^8.1 Zeng, C et al. (2006) Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Circ. Res. 99 494-500 PubMed GONUTS page

[PMID:15913875-9] 9.0 ^9.1 Barik, S & de Beaurepaire, R (2005) Dopamine D3 modulation of locomotor activity and sleep in the nucleus accumbens and in lobules 9 and 10 of the cerebellum in the rat. Prog. Neuropsychopharmacol. Biol. Psychiatry 29 718-26 PubMed GONUTS page

[PMID:9822449-10] O'Connell, DP et al. (1998) Expression of the dopamine D3 receptor protein in the rat kidney. Hypertension 32 886-95 PubMed GONUTS page

[PMID:25989500-11] Wang, Z et al. (2015) Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Gα12. Transplantation 99 2274-84 PubMed GONUTS page

[PMID:15584906-12] 12.0 ^12.1 Coronas, V et al. (2004) Dopamine D3 receptor stimulation promotes the proliferation of cells derived from the post-natal subventricular zone. J. Neurochem. 91 1292-301 PubMed GONUTS page

[PMID:14621190-13] Luippold, G et al. (2003) Dopamine D3 receptor mRNA and renal response to D3 receptor activation in spontaneously hypertensive rats. Hypertens. Res. 26 855-61 PubMed GONUTS page

[PMID:18600456-14] Kashyap, P et al. (2009) The D2/D3 agonist PD128907 (R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol) inhibits stimulated pyloric relaxation and spontaneous gastric emptying. Dig. Dis. Sci. 54 57-62 PubMed GONUTS page

[PMID:16490190-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Roberts, C et al. (2006) Dopamine D3 receptor modulation of dopamine efflux in the rat nucleus accumbens. Eur. J. Pharmacol. 534 108-14 PubMed GONUTS page

[PMID:15265811-16] 16.0 ^16.1 Pedrosa, R et al. (2004) Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells. Br. J. Pharmacol. 142 1343-53 PubMed GONUTS page

[PMID:14732731-17] Zeng, C et al. (2004) Aberrant D1 and D3 dopamine receptor transregulation in hypertension. Hypertension 43 654-60 PubMed GONUTS page

[PMID:14617818-18] 18.0 ^18.1 ^18.2 Jeanneteau, F et al. (2004) Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Mol. Biol. Cell 15 696-705 PubMed GONUTS page

[PMID:26649942-19] Wang, JD et al. (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy 11 2057-2073 PubMed GONUTS page

[PMID:14499480-20] Griffon, N et al. (2003) CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Brain Res. Mol. Brain Res. 117 47-57 PubMed GONUTS page

[PMID:21873635-21] 21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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