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PMID:1975644

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Citation

Sokoloff, P, Giros, B, Martres, MP, Bouthenet, ML and Schwartz, JC (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347:146-51

Abstract

A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.

Links

PubMed Online version:10.1038/347146a0

Keywords

Amino Acid Sequence; Animals; Antipsychotic Agents/pharmacology; Base Sequence; Brain Chemistry; Cell Line; Cloning, Molecular; Cricetinae; DNA/genetics; DNA Restriction Enzymes; Dopamine/metabolism; Guanylyl Imidodiphosphate/pharmacology; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; RNA, Messenger/analysis; Rats; Receptors, Dopamine/drug effects; Receptors, Dopamine/genetics; Receptors, Dopamine/physiology; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Sequence Homology, Nucleic Acid; Tissue Distribution

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:DRD3

involved_in

GO:0009410: response to xenobiotic stimulus

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

RAT:DRD3

involved_in

GO:0009410: response to xenobiotic stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:DRD2

involved_in

GO:0009410: response to xenobiotic stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:DRD3

enables

GO:0001591: dopamine neurotransmitter receptor activity, coupled via Gi/Go

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:DRD3

enables

GO:0008144: drug binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:DRD3

involved_in

GO:0042493: response to drug

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:DRD3

involved_in

GO:0042493: response to drug

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

RAT:DRD3

involved_in

GO:0007212: dopamine receptor signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

RAT:DRD3

enables

GO:0004952: dopamine neurotransmitter receptor activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete


See also

References

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