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PMID:18600456
| Citation |
Kashyap, P, Micci, MA, Pasricha, S and Pasricha, PJ (2009) The D2/D3 agonist PD128907 (R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol) inhibits stimulated pyloric relaxation and spontaneous gastric emptying. Dig. Dis. Sci. 54:57-62 |
|---|---|
| Abstract |
Enteric neuronal dopamine (DA) inhibits acetylcholine release and gastric motility; this has been thought to be mediated via neuronal dopamine-2 receptor (D2R). The aim of this study was to investigate the modulation of gastric motility by the dopamine-3 receptor (D3R). |
| Links |
PubMed Online version:10.1007/s10620-008-0335-6 |
| Keywords |
Animals; Benzopyrans/pharmacology; Dopamine Agonists/pharmacology; Dopamine Antagonists/pharmacology; Dose-Response Relationship, Drug; Electric Stimulation; Gastric Emptying/drug effects; Gastrointestinal Motility/drug effects; Gastrointestinal Motility/physiology; Muscle Relaxation/drug effects; Myenteric Plexus/metabolism; Naphthalenes/pharmacology; Oxazines/pharmacology; Pylorus/drug effects; Pylorus/metabolism; Pyrrolidines/pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2/agonists; Receptors, Dopamine D3/agonists; Receptors, Dopamine D3/antagonists & inhibitors; Receptors, Dopamine D3/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0035483: gastric emptying |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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