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RAT:DNMT1

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Dnmt1
Protein Name(s) DNA (cytosine-5)-methyltransferase 1

Dnmt1 DNA MTase RnoIP M.RnoIP DNA methyltransferase I MCMT

External Links
UniProt Q9Z330
EMBL AB012214
AF116344
AF116345
D64060
AH007612
PIR JE0378
UniGene Rn.6955
ProteinModelPortal Q9Z330
IntAct Q9Z330
STRING 10116.ENSRNOP00000063029
REBASE 3019
PhosphoSite Q9Z330
PaxDb Q9Z330
PRIDE Q9Z330
UCSC RGD:620979
RGD 620979
eggNOG COG0270
HOGENOM HOG000082497
HOVERGEN HBG051384
InParanoid Q9Z330
PhylomeDB Q9Z330
BioCyc MetaCyc:MONOMER-8581
PRO PR:Q9Z330
Proteomes UP000002494
Genevestigator Q9Z330
GO GO:0005737
GO:0043025
GO:0005634
GO:0043234
GO:0003682
GO:0003886
GO:0051718
GO:0003690
GO:0030331
GO:0042826
GO:0008327
GO:0019904
GO:0008757
GO:0045322
GO:0008270
GO:0007568
GO:0007420
GO:0071284
GO:1990090
GO:0036120
GO:0071560
GO:0016568
GO:0044026
GO:0006306
GO:0032776
GO:0010424
GO:0010216
GO:0030182
GO:0006355
GO:0014823
GO:0036276
GO:0042493
GO:0032355
GO:0045471
GO:0009408
GO:0010212
GO:0010288
GO:0031667
GO:0010033
GO:0033574
GO:0009636
GO:0033189
GO:0046498
GO:0046499
GO:0046500
GO:0006351
Gene3D 3.40.50.150
InterPro IPR001025
IPR018117
IPR001525
IPR022702
IPR010506
IPR017198
IPR029063
IPR002857
Pfam PF01426
PF06464
PF12047
PF02008
PIRSF PIRSF037404
PRINTS PR00105
SMART SM00439
SUPFAM SSF53335
PROSITE PS51038
PS00094
PS00095
PS51679
PS51058

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:1990841

promoter-specific chromatin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26358

F

Seeded From UniProt

complete

involved_in

GO:0090309

positive regulation of methylation-dependent chromatin silencing

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26358

P

Seeded From UniProt

complete

involved_in

GO:0007265

Ras protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26358

P

Seeded From UniProt

complete

involved_in

GO:1990090

cellular response to nerve growth factor stimulus

PMID:10407183[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

PMID:24211420[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071284

cellular response to lead ion

PMID:22764079[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046500

S-adenosylmethionine metabolic process

PMID:3856245[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

PMID:24968059[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044026

DNA hypermethylation

PMID:21682946[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

PMID:21682946[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:12473678[7]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:1320331

F

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:22880885[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:16632870[9]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036120

cellular response to platelet-derived growth factor stimulus

PMID:23423710[10]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033574

response to testosterone

PMID:20056826[11]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033189

response to vitamin A

PMID:23333085[12]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:12473678[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032776

DNA methylation on cytosine

PMID:22880885[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

PMID:23271618[13]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

PMID:22334722[14]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

PMID:24270982[15]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031000

response to caffeine

PMID:24717552[16]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030331

estrogen receptor binding

PMID:19683557[17]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:2582

F

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:19660178[18]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:12473678[7]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:3075

F

Seeded From UniProt

complete

involved_in

GO:0014823

response to activity

PMID:23201423[19]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010424

DNA methylation on cytosine within a CG sequence

PMID:3856245[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010288

response to lead ion

PMID:23246732[20]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010216

maintenance of DNA methylation

PMID:12473678[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010212

response to ionizing radiation

PMID:17148264[21]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

PMID:23791455[22]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

PMID:23433207[23]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009408

response to heat

PMID:24270982[15]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

PMID:16702315[24]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:23954679[25]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:19660178[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:3856245[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12473678[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003886

DNA (cytosine-5-)-methyltransferase activity

PMID:12473678[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010424

DNA methylation on cytosine within a CG sequence

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000066774
RGD:620979
TAIR:locus:2155959

P

Seeded From UniProt

complete

involved_in

GO:0010216

maintenance of DNA methylation

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94912
PANTHER:PTN000066774
RGD:620979
TAIR:locus:2155959
UniProtKB:C0SQ89
UniProtKB:P26358

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94912
PANTHER:PTN000066775
RGD:620979

C

Seeded From UniProt

complete

enables

GO:0003886

DNA (cytosine-5-)-methyltransferase activity

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94912
PANTHER:PTN000066774
RGD:620979
TAIR:locus:2117104
TAIR:locus:2205015
UniProtKB:P26358

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94912
PANTHER:PTN000066774
UniProtKB:P26358

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002857

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001025

F

Seeded From UniProt

complete

enables

GO:0003886

DNA (cytosine-5-)-methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017198

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017198

C

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001525

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002857

F

Seeded From UniProt

complete

involved_in

GO:0090116

C-5 methylation of cytosine

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017198

P

Seeded From UniProt

complete

enables

GO:0003886

DNA (cytosine-5-)-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.37

F

Seeded From UniProt

complete

enables

GO:0008757

S-adenosylmethionine-dependent methyltransferase activity

PMID:12473678[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Deng, J & Szyf, M (1999) Downregulation of DNA (cytosine-5-)methyltransferase is a late event in NGF-induced PC12 cell differentiation. Brain Res. Mol. Brain Res. 71 23-31 PubMed GONUTS page
  2. ↑ Bian, EB et al. (2014) Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats. Toxicol. Lett. 224 175-85 PubMed GONUTS page
  3. ↑ Li, YY et al. (2012) Lead exposure in pheochromocytoma cells induces persistent changes in amyloid precursor protein gene methylation patterns. Environ. Toxicol. 27 495-502 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Farrance, IK & Ivarie, R (1985) Ethylation of poly(dC-dG).poly(dC-dG) by ethyl methanesulfonate stimulates the activity of mammalian DNA methyltransferase in vitro. Proc. Natl. Acad. Sci. U.S.A. 82 1045-9 PubMed GONUTS page
  5. ↑ Sakharkar, AJ et al. (2014) Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats. Int. J. Neuropsychopharmacol. 17 2057-67 PubMed GONUTS page
  6. ↑ 6.0 6.1 Melas, PA et al. (2012) Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Int. J. Neuropsychopharmacol. 15 669-79 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Kimura, H & Shiota, K (2003) Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. J. Biol. Chem. 278 4806-12 PubMed GONUTS page
  8. ↑ 8.0 8.1 Zimmermann, N et al. (2012) Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Biochem. J. 448 93-102 PubMed GONUTS page
  9. ↑ Tryndyak, VP et al. (2006) Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis 27 1713-20 PubMed GONUTS page
  10. ↑ Ning, Y et al. (2013) 5-Aza-2'-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching. Arch. Toxicol. 87 871-81 PubMed GONUTS page
  11. ↑ Cowin, PA et al. (2010) Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Endocrinology 151 783-92 PubMed GONUTS page
  12. ↑ Feng, Y et al. (2013) Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. J. Nutr. Biochem. 24 1373-80 PubMed GONUTS page
  13. ↑ Biswas, B & Yenugu, S (2013) Lipopolysaccharide induces epididymal and testicular antimicrobial gene expression in vitro: insights into the epigenetic regulation of sperm-associated antigen 11e gene. Immunogenetics 65 239-53 PubMed GONUTS page
  14. ↑ Meunier, L et al. (2012) Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1. Endocrinology 153 1936-47 PubMed GONUTS page
  15. ↑ 15.0 15.1 Karpe, PA & Tikoo, K (2014) Heat shock prevents insulin resistance-induced vascular complications by augmenting angiotensin-(1-7) signaling. Diabetes 63 1124-39 PubMed GONUTS page
  16. ↑ Ping, J et al. (2014) Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Toxicology 321 53-61 PubMed GONUTS page
  17. ↑ Pathak, S et al. (2010) Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Mol. Cell. Endocrinol. 314 110-7 PubMed GONUTS page
  18. ↑ 18.0 18.1 Singh, RP et al. (2009) Cellular epigenetic modifications of neural stem cell differentiation. Cell Transplant 18 1197-211 PubMed GONUTS page
  19. ↑ Elsner, VR et al. (2013) Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study. Exp. Gerontol. 48 136-9 PubMed GONUTS page
  20. ↑ Schneider, JS et al. (2013) Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus. Toxicol. Lett. 217 75-81 PubMed GONUTS page
  21. ↑ Loree, J et al. (2006) Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Int. J. Radiat. Biol. 82 805-15 PubMed GONUTS page
  22. ↑ Zhou, R et al. (2013) Persistent overexpression of DNA methyltransferase 1 attenuating GABAergic inhibition in basolateral amygdala accounts for anxiety in rat offspring exposed perinatally to low-dose bisphenol A. J Psychiatr Res 47 1535-44 PubMed GONUTS page
  23. ↑ Zhang, Q et al. (2013) [Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 31 92-5 PubMed GONUTS page
  24. ↑ Ghoshal, K et al. (2006) A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. J. Nutr. 136 1522-7 PubMed GONUTS page
  25. ↑ Simmons, RK et al. (2013) DNA methylation markers in the postnatal developing rat brain. Brain Res. 1533 26-36 PubMed GONUTS page
  26. ↑ 26.0 26.1 26.2 26.3 26.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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