RAT:DLG4

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Dlg4 (synonyms: Dlgh4, Psd95)
Protein Name(s)	Disks large homolog 4 Postsynaptic density protein 95 PSD-95 Synapse-associated protein 90 SAP-90 SAP90
External Links
UniProt	P31016
EMBL	M96853 X66474 U77090
PIR	A45436 JH0800
RefSeq	NP_062567.1
UniGene	Rn.9765
PDB	1BE9 1BFE 1IU0 1IU2 1JXM 1JXO 1KJW 1QLC 1RGR 1TP3 1TP5 1TQ3 2KA9 2MHO 2XKX 3GSL 3WP0 3WP1
PDBsum	1BE9 1BFE 1IU0 1IU2 1JXM 1JXO 1KJW 1QLC 1RGR 1TP3 1TP5 1TQ3 2KA9 2MHO 2XKX 3GSL 3WP0 3WP1
ProteinModelPortal	P31016
SMR	P31016
BioGrid	248135
DIP	DIP-29264N
IntAct	P31016
MINT	MINT-93329
PhosphoSite	P31016
PaxDb	P31016
PRIDE	P31016
Ensembl	ENSRNOT00000068493
GeneID	29495
KEGG	rno:29495
UCSC	RGD:68424
CTD	1742
RGD	68424
eggNOG	COG0194
GeneTree	ENSGT00760000118866
HOGENOM	HOG000232102
HOVERGEN	HBG107814
InParanoid	P31016
KO	K11828
OMA	CLEDVMH
OrthoDB	EOG79GT6P
PhylomeDB	P31016
Reactome	REACT_196389 REACT_196392 REACT_196422 REACT_235045 REACT_258022 REACT_258198
EvolutionaryTrace	P31016
NextBio	609380
PRO	PR:P31016
Proteomes	UP000002494
Genevestigator	P31016
GO	GO:0032281 GO:0030054 GO:0044300 GO:0030863 GO:0005737 GO:0032839 GO:0043197 GO:0005783 GO:0060076 GO:0031234 GO:0044224 GO:0044306 GO:0044309 GO:0097481 GO:0014069 GO:0045211 GO:0045202 GO:0008021 GO:0033130 GO:0031697 GO:0031748 GO:0035254 GO:0035255 GO:0031812 GO:0030165 GO:0008022 GO:0032403 GO:0019901 GO:0019903 GO:0005102 GO:0097110 GO:0097113 GO:0060997 GO:0045184 GO:0035641 GO:0002091 GO:0050885 GO:0045161 GO:0007204 GO:2000463 GO:0050806 GO:0006461 GO:0035418 GO:0097120 GO:2000821 GO:0048169 GO:2000310 GO:0035176 GO:0016188 GO:0071625
Gene3D	2.30.42.10 3.40.50.300
InterPro	IPR016313 IPR008145 IPR008144 IPR020590 IPR019590 IPR027417 IPR001478 IPR019583 IPR011511 IPR001452
PANTHER	PTHR23119
Pfam	PF00625 PF10608 PF00595 PF10600 PF07653
PIRSF	PIRSF001741
SMART	SM00072 SM00228 SM00326
SUPFAM	SSF50044 SSF50156 SSF52540
PROSITE	PS00856 PS50052 PS50106 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	PMID:12930820^[1]	ECO:0000315			P		When PSD-95 is mutated this was no increase in NMDA-mEPSC, figure 3C. There was increase in NMDA-mEPSC frequency when PSD-95 is expressed, figure 3D.	complete CACAO 2959
	GO:0050806	positive regulation of synaptic transmission	PMID:12930820^[1]	ECO:0000315			P		When PSD-95 is mutated this was no increase in NMDA-mEPSC, figure 3C. There was increase in NMDA-mEPSC frequency when PSD-95 is expressed, figure 3D.	complete CACAO 2960
	GO:2000463	positive regulation of excitatory postsynaptic membrane potential	PMID:12930820^[1]	ECO:0000315			P		When PSD-95 is mutated this was no increase in NMDA-mEPSC, figure 3C. There was increase in NMDA-mEPSC frequency when PSD-95 is expressed, figure 3D.	complete CACAO 2961
enables	GO:0005109	frizzled binding	PMID:25424568^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61088	F	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0150012	positive regulation of neuron projection arborization	PMID:25424568^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61088	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:17526495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q62844)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:26595655^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019865	immunoglobulin binding	PMID:26595655^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5DX21	F		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:26595655^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019865	immunoglobulin binding	PMID:26595655^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5U2P2	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:27307232^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:27307232^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:14642282^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:10939335^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P24587	F	occurs_in:(UBERON:0001890) occurs_in:(GO:0045202)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:27756895^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:27307232^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:10939335^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P24588	F		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:10939335^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P24587	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0098970	postsynaptic neurotransmitter receptor diffusion trapping	PMID:17329211^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	transports_or_maintains_localization_of:(GO:0032281) occurs_in:(GO:0060076) occurs_in:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0031698	beta-2 adrenergic receptor binding	PMID:20395454^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10608	F	occurs_in:(UBERON:0000451)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:12930820^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:12930820^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	PMID:11368788^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N0W4	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:20089912^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0008076	voltage-gated potassium channel complex	PMID:20089912^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	PMID:20089912^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:2000821	regulation of grooming behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:12930820^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:12930820^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21525273^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	PMID:21525273^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21525273^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	F		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21525273^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:19730411^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	PMID:12930820^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
colocalizes_with	GO:0045211	postsynaptic membrane	PMID:20847060^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P78352	P		Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
involved_in	GO:0035641	locomotory exploration behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	PMID:15620359^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035254	glutamate receptor binding	PMID:20847060^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00959	F	occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	PMID:1419001^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
enables	GO:0031812	P2Y1 nucleotide receptor binding	PMID:20847060^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49651	F	occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:20410104^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:D3ZA31	F		Seeded From UniProt	complete
involved_in	GO:0016188	synaptic vesicle maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:1419001^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:20847060^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49651	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P78352	P		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	PMID:20847060^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62108	C		Seeded From UniProt	complete
enables	GO:0031697	beta-1 adrenergic receptor binding	PMID:11526121^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08588	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:11502259^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:9808460^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42260	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:11274188^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23634-6	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:11274188^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01814-1	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:9808460^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42260	F		Seeded From UniProt	complete
involved_in	GO:0002091	negative regulation of receptor internalization	PMID:11526121^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P08588)	Seeded From UniProt	complete
part_of	GO:0099031	anchored component of postsynaptic density membrane	PMID:20357126^[23]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099031	anchored component of postsynaptic density membrane	PMID:20357126^[23]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21525273^[13]	ECO:0006052	RNAi evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21525273^[13]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20357126^[23]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21525273^[13]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20357126^[23]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:21525273^[13]	ECO:0006052	RNAi evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:21525273^[13]	ECO:0006003	electron microscopy evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:21525273^[13]	ECO:0005589	confocal microscopy evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:14741046^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:22843680^[25]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2518 RGD:621719	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:20197063^[26]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2737 RGD:620795	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:12618293^[27]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2641 RGD:2737 RGD:620795	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:11178875^[28]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620223 RGD:621011 RGD:621667 RGD:631353	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:17270176^[29]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:16606616^[30]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2739	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:16540568^[31]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:16540568^[31]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
enables	GO:0033130	acetylcholine receptor binding	PMID:22593058^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	PMID:23041629^[33]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2518	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:15024025^[34]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621660	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:10644767^[35]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621855	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20220006^[36]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1584969	F		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	PMID:12097473^[37]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621520	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21314939^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:11226670^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:20628354^[40]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:61995	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:16606616^[30]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2739	F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:20531396^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098970	postsynaptic neurotransmitter receptor diffusion trapping	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002508435 RGD:68424	P		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN000563569	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 UniProtKB:Q12959 UniProtKB:Q14160	P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 RGD:68424	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501209 RGD:68424	P		Seeded From UniProt	complete
involved_in	GO:0043113	receptor clustering	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 RGD:619895	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000563569 RGD:2505	C		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN001501163 RGD:2505 RGD:68423 RGD:68424	F		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001624 FB:FBgn0029830 MGI:MGI:107231 PANTHER:PTN000563569	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107231 MGI:MGI:1277959 MGI:MGI:1344351 PANTHER:PTN001501163 UniProtKB:Q12959 UniProtKB:Q14160	C		Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN001501163	C		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001624 MGI:MGI:1344351 PANTHER:PTN000563569	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:11483650^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15681343^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15657400^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:11483650^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	PMID:19109503^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:24613359^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:17310244^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098919	P		Seeded From UniProt	complete
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098919	P		Seeded From UniProt	complete
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098919	P		Seeded From UniProt	complete
involved_in	GO:0045161	neuronal ion channel clustering	PMID:11152698^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-RNO-9617322 Reactome:R-RNO-6797307 Reactome:R-RNO-6794359 Reactome:R-RNO-6794358 Reactome:R-RNO-6794350 Reactome:R-RNO-6794342 Reactome:R-RNO-6794337 Reactome:R-RNO-6794335	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Fu, Z et al. (2003) Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J. Neurophysiol. 90 3950-7 PubMed GONUTS page
↑ ^2.0 ^2.1 Bian, WJ et al. (2015) A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Dev Neurobiol 75 805-22 PubMed GONUTS page
↑ Wu, HY et al. (2007) Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J. Biol. Chem. 282 20075-87 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Jang, S et al. (2016) Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity. Nat. Neurosci. 19 84-93 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yokoi, N et al. (2016) Identification of PSD-95 Depalmitoylating Enzymes. J. Neurosci. 36 6431-44 PubMed GONUTS page
↑ Colledge, M et al. (2003) Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron 40 595-607 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Colledge, M et al. (2000) Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron 27 107-19 PubMed GONUTS page
↑ Rademacher, N et al. (2016) MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Sci Rep 6 35283 PubMed GONUTS page
↑ Bats, C et al. (2007) The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking. Neuron 53 719-34 PubMed GONUTS page
↑ Wang, D et al. (2010) Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. FASEB J. 24 3511-21 PubMed GONUTS page
↑ Bolliger, MF et al. (2001) Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression. Biochem. J. 356 581-8 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Ogawa, Y et al. (2010) ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. J. Neurosci. 30 1038-48 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 ^13.9 Chen, X et al. (2011) PSD-95 is required to sustain the molecular organization of the postsynaptic density. J. Neurosci. 31 6329-38 PubMed GONUTS page
↑ Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Siow, NL et al. (2010) ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Mol. Pharmacol. 78 1059-71 PubMed GONUTS page
↑ Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page
↑ ^17.0 ^17.1 Cho, KO et al. (1992) The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9 929-42 PubMed GONUTS page
↑ Lee, HW et al. (2010) The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic. J. Neurosci. 30 5508-18 PubMed GONUTS page
↑ ^19.0 ^19.1 Xu, J et al. (2001) beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. J. Biol. Chem. 276 41310-7 PubMed GONUTS page
↑ Pak, DT et al. (2001) Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31 289-303 PubMed GONUTS page
↑ ^21.0 ^21.1 Garcia, EP et al. (1998) SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron 21 727-39 PubMed GONUTS page
↑ ^22.0 ^22.1 DeMarco, SJ & Strehler, EE (2001) Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. J. Biol. Chem. 276 21594-600 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Zheng, CY et al. (2010) SAP102 is a highly mobile MAGUK in spines. J. Neurosci. 30 4757-66 PubMed GONUTS page
↑ Sabio, G et al. (2004) Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2. Biochem. J. 380 19-30 PubMed GONUTS page
↑ Ha, CM et al. (2012) Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization. J. Biol. Chem. 287 31813-22 PubMed GONUTS page
↑ Wang, WW et al. (2010) Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Brain Res. 1328 162-70 PubMed GONUTS page
↑ Chen, M et al. (2003) Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia. Neurosci. Lett. 339 29-32 PubMed GONUTS page
↑ Lim, S et al. (2001) Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins. Mol. Cell. Neurosci. 17 385-97 PubMed GONUTS page
↑ Chen, WF et al. (2007) Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia. Exp. Neurol. 204 400-10 PubMed GONUTS page
↑ ^30.0 ^30.1 Chen, BS et al. (2006) Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation. J. Biol. Chem. 281 16583-90 PubMed GONUTS page
↑ ^31.0 ^31.1 Gardoni, F et al. (2006) A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. J. Neurosci. 26 2914-22 PubMed GONUTS page
↑ Gómez-Varela, D et al. (2012) PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons. J. Neurosci. 32 6894-905 PubMed GONUTS page
↑ Porras, G et al. (2012) PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking. J. Clin. Invest. 122 3977-89 PubMed GONUTS page
↑ Leonoudakis, D et al. (2004) Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. J. Biol. Chem. 279 22331-46 PubMed GONUTS page
↑ Hirao, K et al. (2000) Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein. J. Biol. Chem. 275 2966-72 PubMed GONUTS page
↑ Perez de Arce, K et al. (2010) Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J. Neurosci. 30 3728-38 PubMed GONUTS page
↑ Mok, H et al. (2002) Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. J. Neurosci. 22 5253-8 PubMed GONUTS page
↑ Gardoni, F et al. (2011) Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation. J Neuroinflammation 8 14 PubMed GONUTS page
↑ Wyneken, U et al. (2001) Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Neuroscience 102 65-74 PubMed GONUTS page
↑ Jurado, S et al. (2010) PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J. 29 2827-40 PubMed GONUTS page
↑ Pichon, X et al. (2010) Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Mol. Ther. 18 1462-70 PubMed GONUTS page
↑ ^42.00 ^42.01 ^42.02 ^42.03 ^42.04 ^42.05 ^42.06 ^42.07 ^42.08 ^42.09 ^42.10 ^42.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^43.0 ^43.1 Schultze, W et al. (2001) Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95. J. Neurochem. 78 482-9 PubMed GONUTS page
↑ Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page
↑ Osterweil, E et al. (2005) A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J. Cell Biol. 168 329-38 PubMed GONUTS page
↑ Horresh, I et al. (2008) Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. J. Neurosci. 28 14213-22 PubMed GONUTS page
↑ Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page
↑ Segura, I et al. (2007) Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nat. Neurosci. 10 301-10 PubMed GONUTS page
↑ Savinainen, A et al. (2001) Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. J. Biol. Chem. 276 11382-6 PubMed GONUTS page

[PMID:12930820-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Fu, Z et al. (2003) Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J. Neurophysiol. 90 3950-7 PubMed GONUTS page

[PMID:25424568-2] 2.0 ^2.1 Bian, WJ et al. (2015) A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Dev Neurobiol 75 805-22 PubMed GONUTS page

[PMID:17526495-3] Wu, HY et al. (2007) Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J. Biol. Chem. 282 20075-87 PubMed GONUTS page

[PMID:26595655-4] 4.0 ^4.1 ^4.2 ^4.3 Jang, S et al. (2016) Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity. Nat. Neurosci. 19 84-93 PubMed GONUTS page

[PMID:27307232-5] 5.0 ^5.1 ^5.2 Yokoi, N et al. (2016) Identification of PSD-95 Depalmitoylating Enzymes. J. Neurosci. 36 6431-44 PubMed GONUTS page

[PMID:14642282-6] Colledge, M et al. (2003) Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron 40 595-607 PubMed GONUTS page

[PMID:10939335-7] 7.0 ^7.1 ^7.2 Colledge, M et al. (2000) Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron 27 107-19 PubMed GONUTS page

[PMID:27756895-8] Rademacher, N et al. (2016) MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Sci Rep 6 35283 PubMed GONUTS page

[PMID:17329211-9] Bats, C et al. (2007) The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking. Neuron 53 719-34 PubMed GONUTS page

[PMID:20395454-10] Wang, D et al. (2010) Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. FASEB J. 24 3511-21 PubMed GONUTS page

[PMID:11368788-11] Bolliger, MF et al. (2001) Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression. Biochem. J. 356 581-8 PubMed GONUTS page

[PMID:20089912-12] 12.0 ^12.1 ^12.2 Ogawa, Y et al. (2010) ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. J. Neurosci. 30 1038-48 PubMed GONUTS page

[PMID:21525273-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 ^13.9 Chen, X et al. (2011) PSD-95 is required to sustain the molecular organization of the postsynaptic density. J. Neurosci. 31 6329-38 PubMed GONUTS page

[PMID:19730411-14] Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page

[PMID:20847060-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Siow, NL et al. (2010) ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Mol. Pharmacol. 78 1059-71 PubMed GONUTS page

[PMID:15620359-16] Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page

[PMID:1419001-17] 17.0 ^17.1 Cho, KO et al. (1992) The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9 929-42 PubMed GONUTS page

[PMID:20410104-18] Lee, HW et al. (2010) The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic. J. Neurosci. 30 5508-18 PubMed GONUTS page

[PMID:11526121-19] 19.0 ^19.1 Xu, J et al. (2001) beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. J. Biol. Chem. 276 41310-7 PubMed GONUTS page

[PMID:11502259-20] Pak, DT et al. (2001) Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31 289-303 PubMed GONUTS page

[PMID:9808460-21] 21.0 ^21.1 Garcia, EP et al. (1998) SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron 21 727-39 PubMed GONUTS page

[PMID:11274188-22] 22.0 ^22.1 DeMarco, SJ & Strehler, EE (2001) Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. J. Biol. Chem. 276 21594-600 PubMed GONUTS page

[PMID:20357126-23] 23.0 ^23.1 ^23.2 ^23.3 Zheng, CY et al. (2010) SAP102 is a highly mobile MAGUK in spines. J. Neurosci. 30 4757-66 PubMed GONUTS page

[PMID:14741046-24] Sabio, G et al. (2004) Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2. Biochem. J. 380 19-30 PubMed GONUTS page

[PMID:22843680-25] Ha, CM et al. (2012) Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization. J. Biol. Chem. 287 31813-22 PubMed GONUTS page

[PMID:20197063-26] Wang, WW et al. (2010) Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Brain Res. 1328 162-70 PubMed GONUTS page

[PMID:12618293-27] Chen, M et al. (2003) Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia. Neurosci. Lett. 339 29-32 PubMed GONUTS page

[PMID:11178875-28] Lim, S et al. (2001) Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins. Mol. Cell. Neurosci. 17 385-97 PubMed GONUTS page

[PMID:17270176-29] Chen, WF et al. (2007) Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia. Exp. Neurol. 204 400-10 PubMed GONUTS page

[PMID:16606616-30] 30.0 ^30.1 Chen, BS et al. (2006) Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation. J. Biol. Chem. 281 16583-90 PubMed GONUTS page

[PMID:16540568-31] 31.0 ^31.1 Gardoni, F et al. (2006) A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. J. Neurosci. 26 2914-22 PubMed GONUTS page

[PMID:22593058-32] Gómez-Varela, D et al. (2012) PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons. J. Neurosci. 32 6894-905 PubMed GONUTS page

[PMID:23041629-33] Porras, G et al. (2012) PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking. J. Clin. Invest. 122 3977-89 PubMed GONUTS page

[PMID:15024025-34] Leonoudakis, D et al. (2004) Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. J. Biol. Chem. 279 22331-46 PubMed GONUTS page

[PMID:10644767-35] Hirao, K et al. (2000) Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein. J. Biol. Chem. 275 2966-72 PubMed GONUTS page

[PMID:20220006-36] Perez de Arce, K et al. (2010) Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J. Neurosci. 30 3728-38 PubMed GONUTS page

[PMID:12097473-37] Mok, H et al. (2002) Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. J. Neurosci. 22 5253-8 PubMed GONUTS page

[PMID:21314939-38] Gardoni, F et al. (2011) Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation. J Neuroinflammation 8 14 PubMed GONUTS page

[PMID:11226670-39] Wyneken, U et al. (2001) Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Neuroscience 102 65-74 PubMed GONUTS page

[PMID:20628354-40] Jurado, S et al. (2010) PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J. 29 2827-40 PubMed GONUTS page

[PMID:20531396-41] Pichon, X et al. (2010) Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Mol. Ther. 18 1462-70 PubMed GONUTS page

[PMID:21873635-42] 42.00 ^42.01 ^42.02 ^42.03 ^42.04 ^42.05 ^42.06 ^42.07 ^42.08 ^42.09 ^42.10 ^42.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11483650-43] 43.0 ^43.1 Schultze, W et al. (2001) Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95. J. Neurochem. 78 482-9 PubMed GONUTS page

[PMID:15681343-44] Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page

[PMID:15657400-45] Osterweil, E et al. (2005) A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J. Cell Biol. 168 329-38 PubMed GONUTS page

[PMID:19109503-46] Horresh, I et al. (2008) Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. J. Neurosci. 28 14213-22 PubMed GONUTS page

[PMID:24613359-47] Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page

[PMID:17310244-48] Segura, I et al. (2007) Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nat. Neurosci. 10 301-10 PubMed GONUTS page

[PMID:11152698-49] Savinainen, A et al. (2001) Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. J. Biol. Chem. 276 11382-6 PubMed GONUTS page

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