RAT:CUBN

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Cubn (synonyms: Ifcr)
Protein Name(s)	Cubilin 460 kDa receptor Glycoprotein 280 gp280 Intrinsic factor-cobalamin receptor Intrinsic factor-vitamin B12 receptor
External Links
UniProt	O70244
EMBL	AF022247
PIR	T08618
RefSeq	NP_445784.1
UniGene	Rn.3236
ProteinModelPortal	O70244
BioGrid	249486
MINT	MINT-4996242
STRING	10116.ENSRNOP00000048477
PhosphoSite	O70244
PaxDb	O70244
PRIDE	O70244
GeneID	80848
KEGG	rno:80848
UCSC	RGD:68355
CTD	8029
RGD	68355
eggNOG	NOG287752
HOGENOM	HOG000173840
HOVERGEN	HBG080357
InParanoid	O70244
KO	K14616
PhylomeDB	O70244
NextBio	614894
PRO	PR:O70244
Proteomes	UP000002494
Genevestigator	O70244
GO	GO:0031526 GO:0005905 GO:0030135 GO:0030666 GO:0010008 GO:0043202 GO:0005765 GO:0016020 GO:0043234 GO:0005509 GO:0031419 GO:0015235 GO:0030492 GO:0042802 GO:0004872 GO:0008203 GO:0015889 GO:0020028 GO:0001701 GO:0070207 GO:0006898 GO:0007584 GO:0006766
Gene3D	2.60.120.290
InterPro	IPR000859 IPR028876 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR024731
PANTHER	PTHR10127:SF561
Pfam	PF00431 PF00008 PF12947 PF07645
SMART	SM00042 SM00181 SM00179
SUPFAM	SSF49854
PROSITE	PS00010 PS01180 PS00022 PS01186 PS50026 PS01187

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0031526	brush border membrane	PMID:12724130^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:19202329^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:19202329^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030135	coated vesicle	PMID:14576052^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015889	cobalamin transport	PMID:14576052^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038024	cargo receptor activity	PMID:14576052^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:14576052^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0015889)	Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	PMID:14576052^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	PMID:11595644^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043202	lysosomal lumen	PMID:15578272^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:11595644^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042366	cobalamin catabolic process	PMID:14576052^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:11581259^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17990981^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	PMID:17990981^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	PMID:15578272^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030492	hemoglobin binding	PMID:11805171^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0020028	endocytic hemoglobin import	PMID:11805171^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11595644^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:15616221^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:11595644^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14576052^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005798	Golgi-associated vesicle	PMID:14576052^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	PMID:15616221^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 UniProtKB:O60494	C		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 WB:WBGene00004944	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 WB:WBGene00004944	C		Seeded From UniProt	complete
part_of	GO:0043202	lysosomal lumen	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 UniProtKB:O60494	F		Seeded From UniProt	complete
involved_in	GO:0042366	cobalamin catabolic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	P		Seeded From UniProt	complete
involved_in	GO:0040012	regulation of locomotion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 WB:WBGene00004944	P		Seeded From UniProt	complete
enables	GO:0038024	cargo receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	F		Seeded From UniProt	complete
part_of	GO:0032589	neuron projection membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 WB:WBGene00004944	C		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	C		Seeded From UniProt	complete
enables	GO:0030492	hemoglobin binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	F		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 UniProtKB:O60494	C		Seeded From UniProt	complete
part_of	GO:0030135	coated vesicle	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	C		Seeded From UniProt	complete
involved_in	GO:0020028	endocytic hemoglobin import	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355 UniProtKB:O60494	C		Seeded From UniProt	complete
enables	GO:0016247	channel regulator activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 WB:WBGene00004944	F		Seeded From UniProt	complete
involved_in	GO:0015889	cobalamin transport	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	P		Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 WB:WBGene00004944	P		Seeded From UniProt	complete
part_of	GO:0008328	ionotropic glutamate receptor complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 WB:WBGene00004944	C		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	F		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	P		Seeded From UniProt	complete
involved_in	GO:0006972	hyperosmotic response	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 WB:WBGene00004944	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	C		Seeded From UniProt	complete
part_of	GO:0005798	Golgi-associated vesicle	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	C		Seeded From UniProt	complete
involved_in	GO:0001966	thigmotaxis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 WB:WBGene00004944	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002372555 RGD:68355	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20237569^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O70244	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR018097	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:11595644^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006766	vitamin metabolic process	PMID:11595644^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0031419	cobalamin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0846	F		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gburek, J et al. (2003) Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Am. J. Physiol. Renal Physiol. 285 F451-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Tauris, J et al. (2009) Cubilin and megalin co-localize in the neonatal inner ear. Audiol. Neurootol. 14 267-78 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Fyfe, JC et al. (2004) The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood 103 1573-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Yammani, RR et al. (2001) Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy. Am. J. Physiol. Endocrinol. Metab. 281 E900-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Ishida, T et al. (2004) Immunocytochemical analysis of cubilin-mediated endocytosis of high density lipoproteins (HDL) in epithelial cells of the rat visceral yolk sac. Cell Tissue Res. 318 533-43 PubMed GONUTS page
↑ Yammani, RR et al. (2001) Identification and characterization of two distinct ligand binding regions of cubilin. J. Biol. Chem. 276 44777-84 PubMed GONUTS page
↑ ^7.0 ^7.1 Ahuja, R et al. (2008) Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability. Biochem. J. 410 301-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Gburek, J et al. (2002) Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J. Am. Soc. Nephrol. 13 423-30 PubMed GONUTS page
↑ ^9.0 ^9.1 Assémat, E et al. (2005) Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo. Biol. Reprod. 72 1079-86 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 ^10.21 ^10.22 ^10.23 ^10.24 ^10.25 ^10.26 ^10.27 ^10.28 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Andersen, CB et al. (2010) Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes. Nature 464 445-8 PubMed GONUTS page

[PMID:12724130-1] Gburek, J et al. (2003) Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Am. J. Physiol. Renal Physiol. 285 F451-8 PubMed GONUTS page

[PMID:19202329-2] 2.0 ^2.1 Tauris, J et al. (2009) Cubilin and megalin co-localize in the neonatal inner ear. Audiol. Neurootol. 14 267-78 PubMed GONUTS page

[PMID:14576052-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Fyfe, JC et al. (2004) The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood 103 1573-9 PubMed GONUTS page

[PMID:11595644-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Yammani, RR et al. (2001) Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy. Am. J. Physiol. Endocrinol. Metab. 281 E900-7 PubMed GONUTS page

[PMID:15578272-5] 5.0 ^5.1 Ishida, T et al. (2004) Immunocytochemical analysis of cubilin-mediated endocytosis of high density lipoproteins (HDL) in epithelial cells of the rat visceral yolk sac. Cell Tissue Res. 318 533-43 PubMed GONUTS page

[PMID:11581259-6] Yammani, RR et al. (2001) Identification and characterization of two distinct ligand binding regions of cubilin. J. Biol. Chem. 276 44777-84 PubMed GONUTS page

[PMID:17990981-7] 7.0 ^7.1 Ahuja, R et al. (2008) Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability. Biochem. J. 410 301-8 PubMed GONUTS page

[PMID:11805171-8] 8.0 ^8.1 Gburek, J et al. (2002) Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J. Am. Soc. Nephrol. 13 423-30 PubMed GONUTS page

[PMID:15616221-9] 9.0 ^9.1 Assémat, E et al. (2005) Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo. Biol. Reprod. 72 1079-86 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 ^10.21 ^10.22 ^10.23 ^10.24 ^10.25 ^10.26 ^10.27 ^10.28 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20237569-11] Andersen, CB et al. (2010) Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes. Nature 464 445-8 PubMed GONUTS page

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RAT:CUBN

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