RAT:CD4

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Cd4
Protein Name(s)	T-cell surface glycoprotein CD4 T-cell surface antigen T4/Leu-3 W3/25 antigen
External Links
UniProt	P05540
EMBL	M15768
PIR	A27449
RefSeq	NP_036837.1 XP_006237393.1 XP_008761502.1
UniGene	Rn.10748
PDB	1CID
PDBsum	1CID
ProteinModelPortal	P05540
SMR	P05540
BioGrid	247037
MINT	MINT-4996350
STRING	10116.ENSRNOP00000021915
UniCarbKB	P05540
PRIDE	P05540
Ensembl	ENSRNOT00000021915
GeneID	24932
KEGG	rno:24932
UCSC	RGD:2306
CTD	920
RGD	2306
eggNOG	NOG47205
GeneTree	ENSGT00390000001745
HOGENOM	HOG000008696
HOVERGEN	HBG005281
InParanoid	P05540
KO	K06454
OMA	PEAGMWQ
OrthoDB	EOG7HXCQS
PhylomeDB	P05540
TreeFam	TF335974
Reactome	REACT_199179 REACT_233097 REACT_253779 REACT_254949 REACT_260327 REACT_263109
EvolutionaryTrace	P05540
NextBio	604903
PRO	PR:P05540
Proteomes	UP000002494
Genevestigator	P05540
GO	GO:0005788 GO:0005789 GO:0009897 GO:0016021 GO:0045121 GO:0015026 GO:0019901 GO:0008270 GO:0007155 GO:0007166 GO:0001816 GO:0050829 GO:0006955 GO:0006948 GO:0032507 GO:0050850 GO:0050731 GO:0045860 GO:0050870 GO:0045234 GO:0042110 GO:0030217 GO:0045058
Gene3D	2.60.40.10
InterPro	IPR000973 IPR015274 IPR007110 IPR013783 IPR008424 IPR003599 IPR013106 IPR021963
Pfam	PF05790 PF09191 PF12104 PF07686
PRINTS	PR00692
SMART	SM00409
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0005102	signaling receptor binding	PMID:12115612^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35329	F	Seeded From UniProt	complete
involved_in	GO:0045058	T cell selection	PMID:9551897^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01730	P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	PMID:1533274^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01730	P	Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	PMID:8959663^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:10458478^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:15000837^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	PMID:8759780^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:2478646^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:1372996^[9]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2641	F	Seeded From UniProt	complete
enables	GO:0019865	immunoglobulin binding	PMID:2338715^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010524	positive regulation of calcium ion transport into cytosol	PMID:8959663^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:3159821^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:3104900^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 RGD:2306 UniProtKB:P01730	F	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 UniProtKB:P01730	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88335 PANTHER:PTN002605579 UniProtKB:P01730	C	Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 UniProtKB:P01730	F	Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 RGD:2306	P	Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 UniProtKB:P01730	P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88335 PANTHER:PTN002605579 RGD:2306 UniProtKB:P01730	C	Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F	Seeded From UniProt	complete
involved_in	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0050863	regulation of T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0046598	positive regulation of viral entry into host cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0045657	positive regulation of monocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	C	Seeded From UniProt	complete
involved_in	GO:0045058	T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F	Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F	Seeded From UniProt	complete
enables	GO:0042012	interleukin-16 receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F	Seeded From UniProt	complete
enables	GO:0042011	interleukin-16 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F	Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0033674	positive regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0032507	maintenance of protein location in cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	F	Seeded From UniProt	complete
involved_in	GO:0006948	induction by virus of host cell-cell fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	C	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01730 ensembl:ENSP00000011653	P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000973	P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008424	P	Seeded From UniProt	complete
enables	GO:0015026	coreceptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000973	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000973	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008424	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bakker, TR et al. (2002) Comparison of CD22 binding to native CD45 and synthetic oligosaccharide. Eur. J. Immunol. 32 1924-32 PubMed GONUTS page
↑ Frank, GD & Parnes, JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J. Immunol. 160 634-42 PubMed GONUTS page
↑ Seong, RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356 718-20 PubMed GONUTS page
↑ ^4.0 ^4.1 Sakai, T et al. (1996) Function of CD4 molecules in LEC rat thymocytes. J. Vet. Med. Sci. 58 1125-7 PubMed GONUTS page
↑ Nakatsuji, T (1999) Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts. Tohoku J. Exp. Med. 187 215-25 PubMed GONUTS page
↑ Rabanal, M et al. (2003) CD4 expression decrease by antisense oligonucleotides: inhibition of rat T CD4+ cell reactivity. Oligonucleotides 13 217-28 PubMed GONUTS page
↑ Nataf, S et al. (1996) 1,25 Dihydroxyvitamin D3 exerts regional effects in the central nervous system during experimental allergic encephalomyelitis. J. Neuropathol. Exp. Neurol. 55 904-14 PubMed GONUTS page
↑ Zheng, Y et al. (1989) Differential expression of estrogen-regulated CD4 and Ia positive cells in the immature rat uterus. J. Leukoc. Biol. 46 493-6 PubMed GONUTS page
↑ Beyers, AD et al. (1992) Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. U.S.A. 89 2945-9 PubMed GONUTS page
↑ Davis, SJ et al. (1990) Crystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibody. J. Mol. Biol. 213 7-10 PubMed GONUTS page
↑ Jefferies, WA et al. (1985) Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages. J. Exp. Med. 162 117-27 PubMed GONUTS page
↑ Clark, SJ et al. (1987) Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains. Proc. Natl. Acad. Sci. U.S.A. 84 1649-53 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12115612-1] Bakker, TR et al. (2002) Comparison of CD22 binding to native CD45 and synthetic oligosaccharide. Eur. J. Immunol. 32 1924-32 PubMed GONUTS page

[PMID:9551897-2] Frank, GD & Parnes, JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J. Immunol. 160 634-42 PubMed GONUTS page

[PMID:1533274-3] Seong, RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356 718-20 PubMed GONUTS page

[PMID:8959663-4] 4.0 ^4.1 Sakai, T et al. (1996) Function of CD4 molecules in LEC rat thymocytes. J. Vet. Med. Sci. 58 1125-7 PubMed GONUTS page

[PMID:10458478-5] Nakatsuji, T (1999) Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts. Tohoku J. Exp. Med. 187 215-25 PubMed GONUTS page

[PMID:15000837-6] Rabanal, M et al. (2003) CD4 expression decrease by antisense oligonucleotides: inhibition of rat T CD4+ cell reactivity. Oligonucleotides 13 217-28 PubMed GONUTS page

[PMID:8759780-7] Nataf, S et al. (1996) 1,25 Dihydroxyvitamin D3 exerts regional effects in the central nervous system during experimental allergic encephalomyelitis. J. Neuropathol. Exp. Neurol. 55 904-14 PubMed GONUTS page

[PMID:2478646-8] Zheng, Y et al. (1989) Differential expression of estrogen-regulated CD4 and Ia positive cells in the immature rat uterus. J. Leukoc. Biol. 46 493-6 PubMed GONUTS page

[PMID:1372996-9] Beyers, AD et al. (1992) Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. U.S.A. 89 2945-9 PubMed GONUTS page

[PMID:2338715-10] Davis, SJ et al. (1990) Crystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibody. J. Mol. Biol. 213 7-10 PubMed GONUTS page

[PMID:3159821-11] Jefferies, WA et al. (1985) Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages. J. Exp. Med. 162 117-27 PubMed GONUTS page

[PMID:3104900-12] Clark, SJ et al. (1987) Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains. Proc. Natl. Acad. Sci. U.S.A. 84 1649-53 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:CD4

Contents

Annotations

Notes

References

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