PMID:3104900

Citation	Clark, SJ, Jefferies, WA, Barclay, AN, Gagnon, J and Williams, AF (1987) Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains. Proc. Natl. Acad. Sci. U.S.A. 84:1649-53
Abstract	The rat W3/25 antigen was the first marker antigen of helper T lymphocytes to be identified. Subsequently, the human OKT4 antigen (now called CD4) was described, and cell distribution and functional data suggested that W3/25 and OKT4 antigens were homologous. This is now confirmed by the matching of peptide sequences from W3/25 antigen with sequence predicted from rat cDNA clones detected by cross-hybridization with a cDNA probe for human CD4. Analysis of the two sequences suggests an evolutionary origin from a structure with four immunoglobulin-related domains, although only domain 1 at the NH2 terminus meets the standard criteria for an immunoglobulin-related sequence. CD4 domains 2 and 4 contain disulfide bonds but seem like truncated immunoglobulin domains, whereas domain 3 may have a pattern of beta-strands like an immunoglobulin variable domain, but without the disulfide bond.
Links	PubMed PMC304494
Keywords	Amino Acid Sequence; Animals; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface/analysis; Antigens, Surface/genetics; Antigens, Surface/isolation & purification; Base Sequence; DNA/analysis; Humans; Immunoglobulins/analysis; Rats; Rats, Inbred Strains; Receptors, Immunologic/analysis; T-Lymphocytes/immunology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:CD4	part_of	GO:0005886: plasma membrane	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete

References

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