RAT:ADML

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Adm
Protein Name(s)	ADM Adrenomedullin AM Proadrenomedullin N-20 terminal peptide ProAM N-terminal 20 peptide PAMP ProAM-N20
External Links
UniProt	P43145
EMBL	D15069 U15419 BC061775
PIR	JN0766
RefSeq	NP_036847.1 XP_008757909.1
UniGene	Rn.10232
STRING	10116.ENSRNOP00000035811
PhosphoSite	P43145
Ensembl	ENSRNOT00000036718
GeneID	25026
KEGG	rno:25026
UCSC	RGD:2047
CTD	133
RGD	2047
eggNOG	NOG46109
GeneTree	ENSGT00390000000451
HOGENOM	HOG000033821
HOVERGEN	HBG004181
InParanoid	P43145
KO	K12333
OMA	RNKISPQ
OrthoDB	EOG7DC266
PhylomeDB	P43145
TreeFam	TF333447
Reactome	REACT_246814 REACT_252751
NextBio	605159
PRO	PR:P43145
Proteomes	UP000002494
Genevestigator	P43145
GO	GO:0005737 GO:0005615 GO:0031700 GO:0007568 GO:0008209 GO:0060670 GO:0055074 GO:0006171 GO:0019933 GO:0048589 GO:0007565 GO:0002031 GO:0007507 GO:0046879 GO:0008285 GO:0043116 GO:0045906 GO:0001843 GO:0031102 GO:0042475 GO:0031100 GO:0045766 GO:0043065 GO:0030819 GO:0008284 GO:0007204 GO:0010460 GO:2001214 GO:0045909 GO:0002026 GO:0009409 GO:0051384 GO:0001666 GO:0032868 GO:0032496 GO:0010033 GO:0042594 GO:0009611 GO:0060712 GO:0097084 GO:0001570
InterPro	IPR001710 IPR021116
Pfam	PF00214
PRINTS	PR00801

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0007565	female pregnancy	PMID:8524787^[1]	ECO:0000314			P	Figure 5 shows the cerebrovascular effects of AM which were assessed in rat pial arteries in situ (A andB) and canine basilar artery segments in vitro (C).	complete CACAO 3494
involved_in	GO:0097755	positive regulation of blood vessel diameter	PMID:17076625^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	PMID:17766482^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	PMID:16735801^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046879	hormone secretion	PMID:19723921^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:15229133^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:17335899^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	PMID:19828015^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:17327422^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:16378176^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031700	adrenomedullin receptor binding	PMID:7592696^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0031102	neuron projection regeneration	PMID:17101235^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	PMID:16077951^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019933	cAMP-mediated signaling	PMID:12193565^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010460	positive regulation of heart rate	PMID:19520650^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:16278779^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:12193565^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:16432587^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:16157033^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008209	androgen metabolic process	PMID:18094363^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:18166684^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:17301036^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:16260338^[22]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:17446268^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16174584^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002026	regulation of the force of heart contraction	PMID:19520650^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:17251392^[25]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:1990410	adrenomedullin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
involved_in	GO:0097647	amylin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
involved_in	GO:0045906	negative regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
involved_in	GO:0035809	regulation of urine volume	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
enables	GO:0031700	adrenomedullin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	F	Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
involved_in	GO:0010460	positive regulation of heart rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	C	Seeded From UniProt	complete
involved_in	GO:0003073	regulation of systemic arterial blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35318 ensembl:ENSP00000436607	P	Seeded From UniProt	complete
involved_in	GO:2001214	positive regulation of vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
involved_in	GO:0097084	vascular smooth muscle cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
involved_in	GO:0060712	spongiotrophoblast layer development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
involved_in	GO:0060670	branching involved in labyrinthine layer morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
involved_in	GO:0043116	negative regulation of vascular permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97297 ensembl:ENSMUSP00000033054	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001710 InterPro:IPR021116	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001710 InterPro:IPR021116	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wang, X et al. (1995) Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage. Proc. Natl. Acad. Sci. U.S.A. 92 11480-4 PubMed GONUTS page
↑ Kaneko, Y et al. (2006) Vasodilator effects of adrenomedullin on retinal arterioles in streptozotocin-induced diabetic rats. J Ocul Pharmacol Ther 22 317-22 PubMed GONUTS page
↑ Zhang, XH et al. (2007) The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway. Am. J. Physiol. Heart Circ. Physiol. 293 H2888-93 PubMed GONUTS page
↑ Iwatsubo, S et al. (2006) Increased production of adrenomedullin in glomeruli from anti-glomerular basement membrane glomerulonephritis rats treated with methylprednisolone. Nephron Exp. Nephrol. 104 e41-7 PubMed GONUTS page
↑ White, MM & Samson, WK (2009) A possible relationship between brain-derived adrenomedullin and oxytocin in the regulation of sodium balance. J. Endocrinol. 203 253-62 PubMed GONUTS page
↑ Penchalaneni, J et al. (2004) Adrenomedullin antagonist treatment during early gestation in rats causes fetoplacental growth restriction through apoptosis. Biol. Reprod. 71 1475-83 PubMed GONUTS page
↑ Man, SY et al. (2007) Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation. Neuropeptides 41 177-87 PubMed GONUTS page
↑ Musson, DS et al. (2010) Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization. Biol. Cell 102 145-57 PubMed GONUTS page
↑ Harmancey, R et al. (2007) Adrenomedullin inhibits adipogenesis under transcriptional control of insulin. Diabetes 56 553-63 PubMed GONUTS page
↑ Hussain, S et al. (2005) Possible involvement of adrenomedullin in lipopolysaccharide-induced small-intestinal motility changes in conscious rats. J. Gastroenterol. 40 1123-9 PubMed GONUTS page
↑ Kapas, S et al. (1995) Cloning and expression of cDNA encoding a rat adrenomedullin receptor. J. Biol. Chem. 270 25344-7 PubMed GONUTS page
↑ Hobara, N et al. (2007) Adrenomedullin facilitates reinnervation of phenol-injured perivascular nerves in the rat mesenteric resistance artery. Neuroscience 144 721-30 PubMed GONUTS page
↑ Albertin, G et al. (2005) Adrenomedullin and vascular endothelium growth factor genes are overexpressed in the regenerating rat adrenal cortex, and AM and VEGF reciprocally enhance their mRNA expression in cultured rat adrenocortical cells. Int. J. Mol. Med. 16 431-5 PubMed GONUTS page
↑ ^14.0 ^14.1 Tokudome, T et al. (2002) Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism. Endocrinology 143 3515-21 PubMed GONUTS page
↑ ^15.0 ^15.1 Kaygisiz, Z et al. (2009) Effects of proadrenomedullin N-terminal 20 peptide and calcitonin on isolated perfused rat hearts. Anadolu Kardiyol Derg 9 176-82 PubMed GONUTS page
↑ Tang, F et al. (2005) Ether stress increases adrenomedullin gene expression and levels in the rat adrenal. Horm. Metab. Res. 37 585-8 PubMed GONUTS page
↑ Al-Ayadhi, LY et al. (2006) The effect of vitamin E, L-arginine, N-nitro L-arginine methyl ester and forskolin on endocrine and metabolic changes of rats exposed to acute cold stress. Saudi Med J 27 17-22 PubMed GONUTS page
↑ Liu, XG et al. (2005) Study on the signalling pathway of inhibitory effect of adreno-medullin on the growth of cultured glomerular mesangial cells. Chin. Med. J. 118 1374-9 PubMed GONUTS page
↑ Chan, YF et al. (2008) Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell. Biol. Reprod. 78 773-9 PubMed GONUTS page
↑ Li, YY et al. (2007) Effect of aging on the expression of adrenomedullin and its receptor component proteins in the male reproductive system of the rat. J. Gerontol. A Biol. Sci. Med. Sci. 62 1346-51 PubMed GONUTS page
↑ Hwang, IS et al. (2007) Age-related changes in adrenomedullin expression and hypoxia-inducible factor-1 activity in the rat lung and their responses to hypoxia. J. Gerontol. A Biol. Sci. Med. Sci. 62 41-9 PubMed GONUTS page
↑ van der Heijden, OW et al. (2005) Vascular expression of adrenomedullin is increased in Wistar rats during early pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol. 123 35-40 PubMed GONUTS page
↑ Xu, Y & Krukoff, TL (2007) Adrenomedullin stimulates nitric oxide production from primary rat hypothalamic neurons: roles of calcium and phosphatases. Mol. Pharmacol. 72 112-20 PubMed GONUTS page
↑ Xu, CS et al. (2005) [Dynamic changes in plasma adrenomedullin levels and effect of enalapril intervention in diabetic rats]. Di Yi Jun Yi Da Xue Xue Bao 25 1149-51 PubMed GONUTS page
↑ Dschietzig, T et al. (2007) Hypoxic induction of receptor activity-modifying protein 2 alters regulation of pulmonary endothelin-1 by adrenomedullin: induction under normoxia versus inhibition under hypoxia. J. Pharmacol. Exp. Ther. 321 409-19 PubMed GONUTS page

[PMID:8524787-1] Wang, X et al. (1995) Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage. Proc. Natl. Acad. Sci. U.S.A. 92 11480-4 PubMed GONUTS page

[PMID:17076625-2] Kaneko, Y et al. (2006) Vasodilator effects of adrenomedullin on retinal arterioles in streptozotocin-induced diabetic rats. J Ocul Pharmacol Ther 22 317-22 PubMed GONUTS page

[PMID:17766482-3] Zhang, XH et al. (2007) The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway. Am. J. Physiol. Heart Circ. Physiol. 293 H2888-93 PubMed GONUTS page

[PMID:16735801-4] Iwatsubo, S et al. (2006) Increased production of adrenomedullin in glomeruli from anti-glomerular basement membrane glomerulonephritis rats treated with methylprednisolone. Nephron Exp. Nephrol. 104 e41-7 PubMed GONUTS page

[PMID:19723921-5] White, MM & Samson, WK (2009) A possible relationship between brain-derived adrenomedullin and oxytocin in the regulation of sodium balance. J. Endocrinol. 203 253-62 PubMed GONUTS page

[PMID:15229133-6] Penchalaneni, J et al. (2004) Adrenomedullin antagonist treatment during early gestation in rats causes fetoplacental growth restriction through apoptosis. Biol. Reprod. 71 1475-83 PubMed GONUTS page

[PMID:17335899-7] Man, SY et al. (2007) Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation. Neuropeptides 41 177-87 PubMed GONUTS page

[PMID:19828015-8] Musson, DS et al. (2010) Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization. Biol. Cell 102 145-57 PubMed GONUTS page

[PMID:17327422-9] Harmancey, R et al. (2007) Adrenomedullin inhibits adipogenesis under transcriptional control of insulin. Diabetes 56 553-63 PubMed GONUTS page

[PMID:16378176-10] Hussain, S et al. (2005) Possible involvement of adrenomedullin in lipopolysaccharide-induced small-intestinal motility changes in conscious rats. J. Gastroenterol. 40 1123-9 PubMed GONUTS page

[PMID:7592696-11] Kapas, S et al. (1995) Cloning and expression of cDNA encoding a rat adrenomedullin receptor. J. Biol. Chem. 270 25344-7 PubMed GONUTS page

[PMID:17101235-12] Hobara, N et al. (2007) Adrenomedullin facilitates reinnervation of phenol-injured perivascular nerves in the rat mesenteric resistance artery. Neuroscience 144 721-30 PubMed GONUTS page

[PMID:16077951-13] Albertin, G et al. (2005) Adrenomedullin and vascular endothelium growth factor genes are overexpressed in the regenerating rat adrenal cortex, and AM and VEGF reciprocally enhance their mRNA expression in cultured rat adrenocortical cells. Int. J. Mol. Med. 16 431-5 PubMed GONUTS page

[PMID:12193565-14] 14.0 ^14.1 Tokudome, T et al. (2002) Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism. Endocrinology 143 3515-21 PubMed GONUTS page

[PMID:19520650-15] 15.0 ^15.1 Kaygisiz, Z et al. (2009) Effects of proadrenomedullin N-terminal 20 peptide and calcitonin on isolated perfused rat hearts. Anadolu Kardiyol Derg 9 176-82 PubMed GONUTS page

[PMID:16278779-16] Tang, F et al. (2005) Ether stress increases adrenomedullin gene expression and levels in the rat adrenal. Horm. Metab. Res. 37 585-8 PubMed GONUTS page

[PMID:16432587-17] Al-Ayadhi, LY et al. (2006) The effect of vitamin E, L-arginine, N-nitro L-arginine methyl ester and forskolin on endocrine and metabolic changes of rats exposed to acute cold stress. Saudi Med J 27 17-22 PubMed GONUTS page

[PMID:16157033-18] Liu, XG et al. (2005) Study on the signalling pathway of inhibitory effect of adreno-medullin on the growth of cultured glomerular mesangial cells. Chin. Med. J. 118 1374-9 PubMed GONUTS page

[PMID:18094363-19] Chan, YF et al. (2008) Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell. Biol. Reprod. 78 773-9 PubMed GONUTS page

[PMID:18166684-20] Li, YY et al. (2007) Effect of aging on the expression of adrenomedullin and its receptor component proteins in the male reproductive system of the rat. J. Gerontol. A Biol. Sci. Med. Sci. 62 1346-51 PubMed GONUTS page

[PMID:17301036-21] Hwang, IS et al. (2007) Age-related changes in adrenomedullin expression and hypoxia-inducible factor-1 activity in the rat lung and their responses to hypoxia. J. Gerontol. A Biol. Sci. Med. Sci. 62 41-9 PubMed GONUTS page

[PMID:16260338-22] van der Heijden, OW et al. (2005) Vascular expression of adrenomedullin is increased in Wistar rats during early pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol. 123 35-40 PubMed GONUTS page

[PMID:17446268-23] Xu, Y & Krukoff, TL (2007) Adrenomedullin stimulates nitric oxide production from primary rat hypothalamic neurons: roles of calcium and phosphatases. Mol. Pharmacol. 72 112-20 PubMed GONUTS page

[PMID:16174584-24] Xu, CS et al. (2005) [Dynamic changes in plasma adrenomedullin levels and effect of enalapril intervention in diabetic rats]. Di Yi Jun Yi Da Xue Xue Bao 25 1149-51 PubMed GONUTS page

[PMID:17251392-25] Dschietzig, T et al. (2007) Hypoxic induction of receptor activity-modifying protein 2 alters regulation of pulmonary endothelin-1 by adrenomedullin: induction under normoxia versus inhibition under hypoxia. J. Pharmacol. Exp. Ther. 321 409-19 PubMed GONUTS page

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RAT:ADML

Contents

Annotations

Notes

References

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