RAT:A0A0G2JU33

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Asxl1 (ECO:0000313 with Ensembl:ENSRNOP00000068945)
Protein Name(s)	Protein Asxl1 (ECO:0000313 with Ensembl:ENSRNOP00000068945)
External Links
UniProt	A0A0G2JU33
EMBL	AABR07054337 AABR07054338 AABR07054339
Ensembl	ENSRNOT00000091808
GeneTree	ENSGT00520000055578
Proteomes	UP000002494
GO	GO:0003677 GO:0006355 GO:0006351
InterPro	IPR026905 IPR024811 IPR028020 IPR024815 IPR007759
PANTHER	PTHR13578 PTHR13578:SF19
Pfam	PF13919 PF05066 PF13922

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0010888	negative regulation of lipid storage	PMID:24321552^[1]	ECO:0000315			P	Figure 4B shows that ASXL1 knockdown increased intracellular lipid accumulation after cells were treated with 0.1 mM palmitate.	complete CACAO 11502
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2684063 PANTHER:PTN000339786 UniProtKB:Q76L83	P	Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2684063 PANTHER:PTN000339788 UniProtKB:Q76L83	F	Seeded From UniProt	complete
part_of	GO:0035517	PR-DUB complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261823 PANTHER:PTN000339786 UniProtKB:Q8IXJ9	C	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2684063 PANTHER:PTN000339786	P	Seeded From UniProt	complete
colocalizes_with	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261823 MGI:MGI:1922552 MGI:MGI:2684063 PANTHER:PTN000339786	C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261823 PANTHER:PTN000339786	F	Seeded From UniProt	complete
colocalizes_with	GO:0000790	nuclear chromatin	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922552 PANTHER:PTN000339786	C	Seeded From UniProt	complete
involved_in	GO:0060430	lung saccule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0048872	homeostasis of number of cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0048539	bone marrow development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0048534	hematopoietic or lymphoid organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0048386	positive regulation of retinoic acid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	F	Seeded From UniProt	complete
enables	GO:0042974	retinoic acid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	F	Seeded From UniProt	complete
involved_in	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	F	Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P59598 ensembl:ENSMUSP00000105413	P	Seeded From UniProt	complete
involved_in	GO:0035522	monoubiquitinated histone H2A deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IXJ9 ensembl:ENSP00000364839	P	Seeded From UniProt	complete
part_of	GO:0035517	PR-DUB complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IXJ9 ensembl:ENSP00000364839	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026905	F	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007759	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007759	P	Seeded From UniProt	complete
	GO:0010888	negative regulation of lipid storage	PMID:24321552^[1]	ECO:0000315			P	Figure 4B shows that ASXL1 knockdown increased intracellular lipid accumulation after cells were treated with 0.1 mM palmitate.	complete CACAO 11340
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Park, UH et al. (2014) Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis. Biochem. Biophys. Res. Commun. 443 489-94 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24321552-1] 1.0 ^1.1 Park, UH et al. (2014) Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis. Biochem. Biophys. Res. Commun. 443 489-94 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:A0A0G2JU33

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