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RABIT:DAG1

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Species (Taxon ID) Oryctolagus cuniculus (Rabbit). (9986)
Gene Name(s) DAG1
Protein Name(s) Dystroglycan

Dystrophin-associated glycoprotein 1 Alpha-dystroglycan Alpha-DG Beta-dystroglycan Beta-DG

External Links
UniProt Q28685
EMBL X64393
PIR PN0662
PN0663
S20582
RefSeq NP_001095170.1
UniGene Ocu.2077
ProteinModelPortal Q28685
SMR Q28685
DIP DIP-679N
IntAct Q28685
MINT MINT-1534332
STRING 9986.ENSOCUP00000002981
MEROPS S72.001
UniCarbKB Q28685
Ensembl ENSOCUT00000003437
GeneID 100009278
CTD 1605
eggNOG NOG266557
GeneTree ENSGT00390000008429
HOGENOM HOG000072580
HOVERGEN HBG000078
InParanoid Q28685
OMA AMICYRK
OrthoDB EOG7KSX82
TreeFam TF328370
Proteomes UP000001811
GO GO:0005604
GO:0009279
GO:0005911
GO:0070938
GO:0005737
GO:0005856
GO:0016011
GO:0016010
GO:0005576
GO:0005615
GO:0070062
GO:0030175
GO:0005925
GO:0016021
GO:0030027
GO:0045121
GO:0033268
GO:0005654
GO:0005886
GO:0045211
GO:0042383
GO:0005509
GO:0043237
GO:0008307
GO:0071711
GO:0060445
GO:0071679
GO:0007016
GO:0060441
GO:0006509
GO:0034453
GO:0019048
GO:0002011
GO:0022011
GO:0030336
GO:0043409
GO:0051898
GO:0021682
GO:0006607
Gene3D 2.60.40.10
3.30.70.1040
InterPro IPR027468
IPR006644
IPR015919
IPR008465
IPR013783
IPR030398
Pfam PF05454
SMART SM00736
SUPFAM SSF111006
SSF49313
PROSITE PS51699

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0035556

intracellular signal transduction

PMID:12885773[1]

ECO:0000314

P

Figures 1, 3, 4, 5, 8, & 9 show how beta dystrophin is part of the signal cascade.

complete
CACAO 5908

involved_in

GO:0035556

intracellular signal transduction

PMID:12885773[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043237

laminin-1 binding

PMID:1741056[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016010

dystrophin-associated glycoprotein complex

PMID:1913804[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1904261

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

part_of

GO:0070938

contractile ring

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

involved_in

GO:0051898

negative regulation of protein kinase B signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

enables

GO:0051393

alpha-actinin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

F

Seeded From UniProt

complete

involved_in

GO:0043409

negative regulation of MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

enables

GO:0042169

SH2 domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

F

Seeded From UniProt

complete

involved_in

GO:0034453

microtubule anchoring

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

part_of

GO:0030175

filopodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

involved_in

GO:0019048

modulation by virus of host morphology or physiology

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

enables

GO:0017166

vinculin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

part_of

GO:0016010

dystrophin-associated glycoprotein complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

F

Seeded From UniProt

complete

involved_in

GO:0010717

regulation of epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

involved_in

GO:0010470

regulation of gastrulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

enables

GO:0008307

structural constituent of muscle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

F

Seeded From UniProt

complete

involved_in

GO:0007016

cytoskeletal anchoring at plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

involved_in

GO:0006509

membrane protein ectodomain proteolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

P

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14118
ensembl:ENSP00000442600

F

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

involved_in

GO:0098942

retrograde trans-synaptic signaling by trans-synaptic protein complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

involved_in

GO:0098696

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

involved_in

GO:0071711

basement membrane organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

involved_in

GO:0071679

commissural neuron axon guidance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

involved_in

GO:0060445

branching involved in salivary gland morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

involved_in

GO:0060441

epithelial tube branching involved in lung morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

involved_in

GO:0050807

regulation of synapse organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

part_of

GO:0042383

sarcolemma

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

part_of

GO:0033268

node of Ranvier

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

involved_in

GO:0022011

myelination in peripheral nervous system

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

involved_in

GO:0021682

nerve maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

part_of

GO:0016011

dystroglycan complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

involved_in

GO:0014044

Schwann cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

C

Seeded From UniProt

complete

enables

GO:0002162

dystroglycan binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

F

Seeded From UniProt

complete

involved_in

GO:0002011

morphogenesis of an epithelial sheet

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62165
ensembl:ENSMUSP00000142109

P

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015919

F

Seeded From UniProt

complete

involved_in

GO:0007016

cytoskeletal anchoring at plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008465

P

Seeded From UniProt

complete

part_of

GO:0016010

dystrophin-associated glycoprotein complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008465

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006644
InterPro:IPR015919

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-NUL-2426616

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-NUL-2426616

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0628
UniProtKB-SubCell:SL-0219

C

Seeded From UniProt

complete

part_of

GO:0042383

sarcolemma

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0238

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Oak, SA et al. (2003) Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. J. Biol. Chem. 278 39287-95 PubMed GONUTS page
  2. Ibraghimov-Beskrovnaya, O et al. (1992) Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature 355 696-702 PubMed GONUTS page
  3. Ervasti, JM & Campbell, KP (1991) Membrane organization of the dystrophin-glycoprotein complex. Cell 66 1121-31 PubMed GONUTS page