RABIT:DAG1

Species (Taxon ID)	Oryctolagus cuniculus (Rabbit). (9986)
Gene Name(s)	DAG1
Protein Name(s)	Dystroglycan Dystrophin-associated glycoprotein 1 Alpha-dystroglycan Alpha-DG Beta-dystroglycan Beta-DG
External Links
UniProt	Q28685
EMBL	X64393
PIR	PN0662 PN0663 S20582
RefSeq	NP_001095170.1
UniGene	Ocu.2077
ProteinModelPortal	Q28685
SMR	Q28685
DIP	DIP-679N
IntAct	Q28685
MINT	MINT-1534332
STRING	9986.ENSOCUP00000002981
MEROPS	S72.001
UniCarbKB	Q28685
Ensembl	ENSOCUT00000003437
GeneID	100009278
CTD	1605
eggNOG	NOG266557
GeneTree	ENSGT00390000008429
HOGENOM	HOG000072580
HOVERGEN	HBG000078
InParanoid	Q28685
OMA	AMICYRK
OrthoDB	EOG7KSX82
TreeFam	TF328370
Proteomes	UP000001811
GO	GO:0005604 GO:0009279 GO:0005911 GO:0070938 GO:0005737 GO:0005856 GO:0016011 GO:0016010 GO:0005576 GO:0005615 GO:0070062 GO:0030175 GO:0005925 GO:0016021 GO:0030027 GO:0045121 GO:0033268 GO:0005654 GO:0005886 GO:0045211 GO:0042383 GO:0005509 GO:0043237 GO:0008307 GO:0071711 GO:0060445 GO:0071679 GO:0007016 GO:0060441 GO:0006509 GO:0034453 GO:0019048 GO:0002011 GO:0022011 GO:0030336 GO:0043409 GO:0051898 GO:0021682 GO:0006607
Gene3D	2.60.40.10 3.30.70.1040
InterPro	IPR027468 IPR006644 IPR015919 IPR008465 IPR013783 IPR030398
Pfam	PF05454
SMART	SM00736
SUPFAM	SSF111006 SSF49313
PROSITE	PS51699

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0035556	intracellular signal transduction	PMID:12885773^[1]	ECO:0000314			P	Figures 1, 3, 4, 5, 8, & 9 show how beta dystrophin is part of the signal cascade.	complete CACAO 5908
involved_in	GO:0035556	intracellular signal transduction	PMID:12885773^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043237	laminin-1 binding	PMID:1741056^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016010	dystrophin-associated glycoprotein complex	PMID:1913804^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1904261	positive regulation of basement membrane assembly involved in embryonic body morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
part_of	GO:0070938	contractile ring	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
enables	GO:0051393	alpha-actinin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	F	Seeded From UniProt	complete
involved_in	GO:0043409	negative regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	F	Seeded From UniProt	complete
involved_in	GO:0034453	microtubule anchoring	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
involved_in	GO:0019048	modulation by virus of host morphology or physiology	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
enables	GO:0017166	vinculin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
part_of	GO:0016010	dystrophin-associated glycoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	F	Seeded From UniProt	complete
involved_in	GO:0010717	regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
involved_in	GO:0010470	regulation of gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
enables	GO:0008307	structural constituent of muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	F	Seeded From UniProt	complete
involved_in	GO:0007016	cytoskeletal anchoring at plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	P	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14118 ensembl:ENSP00000442600	F	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
involved_in	GO:0098942	retrograde trans-synaptic signaling by trans-synaptic protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
involved_in	GO:0071711	basement membrane organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
involved_in	GO:0060445	branching involved in salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
involved_in	GO:0060441	epithelial tube branching involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
part_of	GO:0033268	node of Ranvier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
involved_in	GO:0022011	myelination in peripheral nervous system	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
involved_in	GO:0021682	nerve maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
part_of	GO:0016011	dystroglycan complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
involved_in	GO:0014044	Schwann cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	C	Seeded From UniProt	complete
enables	GO:0002162	dystroglycan binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	F	Seeded From UniProt	complete
involved_in	GO:0002011	morphogenesis of an epithelial sheet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62165 ensembl:ENSMUSP00000142109	P	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015919	F	Seeded From UniProt	complete
involved_in	GO:0007016	cytoskeletal anchoring at plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008465	P	Seeded From UniProt	complete
part_of	GO:0016010	dystrophin-associated glycoprotein complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008465	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006644 InterPro:IPR015919	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-2426616	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-2426616	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Oak, SA et al. (2003) Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. J. Biol. Chem. 278 39287-95 PubMed GONUTS page
↑ Ibraghimov-Beskrovnaya, O et al. (1992) Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature 355 696-702 PubMed GONUTS page
↑ Ervasti, JM & Campbell, KP (1991) Membrane organization of the dystrophin-glycoprotein complex. Cell 66 1121-31 PubMed GONUTS page

[PMID:12885773-1] 1.0 ^1.1 Oak, SA et al. (2003) Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. J. Biol. Chem. 278 39287-95 PubMed GONUTS page

[PMID:1741056-2] Ibraghimov-Beskrovnaya, O et al. (1992) Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature 355 696-702 PubMed GONUTS page

[PMID:1913804-3] Ervasti, JM & Campbell, KP (1991) Membrane organization of the dystrophin-glycoprotein complex. Cell 66 1121-31 PubMed GONUTS page

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RABIT:DAG1

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