PMID:6646234

Citation	Mekalanos, JJ, Swartz, DJ, Pearson, GD, Harford, N, Groyne, F and de Wilde, M Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development. Nature 306:551-7
Abstract	Nucleotide sequence and deletion analysis have been used to identify the regulatory and coding sequences comprising the cholera toxin operon (ctx). Incorporation of defined in vitro-generated ctx deletion mutations into Vibrio cholerae by in vivo genetic recombination produced strains which have practical value in cholera vaccine development.
Links	PubMed
Keywords	Base Sequence; Cholera Toxin/genetics; Cholera Vaccines; Cloning, Molecular; Gene Expression Regulation; Operon; Recombination, Genetic; Vibrio cholerae/genetics
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
VIBCH:CHTA	involved_in	GO:0009405: pathogenesis	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
VIBCH:CHTA	involved_in	GO:0006471: protein ADP-ribosylation	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
VIBCH:CHTA	enables	GO:0003950: NAD+ ADP-ribosyltransferase activity	ECO:0000315: mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
VIBCH:CHTA	involved_in	GO:0031640: killing of cells of other organism	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
VIBCH:CHTB	involved_in	GO:0006471: protein ADP-ribosylation	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
VIBCH:CHTB	involved_in	GO:0009405: pathogenesis	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
VIBCH:CHTB	involved_in	GO:0031640: killing of cells of other organism	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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