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VIBCH:CHTB
Contents
| Species (Taxon ID) | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961). (243277) | |
| Gene Name(s) | ctxB (synonyms: toxB) | |
| Protein Name(s) | Cholera enterotoxin subunit B
Cholera enterotoxin B chain Cholera enterotoxin gamma chain Choleragenoid | |
| External Links | ||
| UniProt | P01556 | |
| EMBL | K01170 X00171 X76390 X76391 X58786 D30053 AE003852 | |
| PIR | S14624 | |
| RefSeq | NP_231099.1 WP_000593522.1 | |
| PDB | 1CHP 1CHQ 1CT1 1FGB 1G8Z 1JR0 1MD2 1RCV 1RD9 1RDP 1RF2 1S5B 1S5C 1S5D 1S5E 1S5F 1XTC 2CHB 3CHB 3EFX | |
| PDBsum | 1CHP 1CHQ 1CT1 1FGB 1G8Z 1JR0 1MD2 1RCV 1RD9 1RDP 1RF2 1S5B 1S5C 1S5D 1S5E 1S5F 1XTC 2CHB 3CHB 3EFX | |
| ProteinModelPortal | P01556 | |
| DIP | DIP-6256N | |
| IntAct | P01556 | |
| MINT | MINT-7040506 | |
| STRING | 243277.VC1456 | |
| DNASU | 2613962 | |
| EnsemblBacteria | AAF94613 | |
| GeneID | 2613962 | |
| KEGG | vch:VC1456 | |
| PATRIC | 20081974 | |
| KO | K10929 | |
| OMA | HIDSQKK | |
| OrthoDB | EOG6FV8CW | |
| BioCyc | VCHO:VC1456-MONOMER | |
| EvolutionaryTrace | P01556 | |
| PRO | PR:P01556 | |
| Proteomes | UP000000584 | |
| GO | GO:0020002 GO:0016020 GO:0046812 GO:0031640 GO:0009405 GO:0042517 GO:0006471 | |
| InterPro | IPR008992 IPR001835 | |
| Pfam | PF01376 | |
| PRINTS | PR00772 | |
| ProDom | PD012805 | |
| SUPFAM | SSF50203 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
ECO:0000314 |
P |
Figure 2 (A) Shows Cholera elevates the levels of phosphorylation in STAT3 over time. |
complete | |||||
| GO:0042977 |
activation of JAK2 kinase activity |
ECO:0000314 |
P |
Figure 2 (B) Shows that Cholera elevates levels of phosphorylation in JAK2 overtime. |
complete | |||||
|
part_of |
GO:1902494 |
catalytic complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005534 |
galactose binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042597 |
periplasmic space |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046812 |
host cell surface binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006471 |
protein ADP-ribosylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044764 |
multi-organism cellular process |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046812 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090729 |
toxin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Shu, M et al. (2011) Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells. Mol Oncol 5 265-72 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 O'Neal, CJ et al. (2004) Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism. Biochemistry 43 3772-82 PubMed GONUTS page
- ↑ Merritt, EA et al. (1997) Structural studies of receptor binding by cholera toxin mutants. Protein Sci. 6 1516-28 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Mekalanos, JJ et al. () Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development. Nature 306 551-7 PubMed GONUTS page
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