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VIBCH:CHTA
Contents
| Species (Taxon ID) | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961). (243277) | |
| Gene Name(s) | ctxA (synonyms: toxA) | |
| Protein Name(s) | Cholera enterotoxin subunit A
Cholera enterotoxin, A chain Cholera enterotoxin subunit A1 Cholera enterotoxin A1 chain Cholera enterotoxin alpha chain NAD(+)--diphthamide ADP-ribosyltransferase Cholera enterotoxin subunit A2 Cholera enterotoxin A2 chain Cholera enterotoxin gamma chain | |
| External Links | ||
| UniProt | P01555 | |
| EMBL | X00171 X58785 D30053 X58786 K02679 AF175708 AE003852 K01170 D30052 | |
| PIR | A05129 | |
| RefSeq | NP_231100.1 WP_001881225.1 | |
| PDB | 1S5B 1S5C 1S5D 1S5E 1S5F 1XTC 2A5D 2A5F 2A5G | |
| PDBsum | 1S5B 1S5C 1S5D 1S5E 1S5F 1XTC 2A5D 2A5F 2A5G | |
| DisProt | DP00250 | |
| ProteinModelPortal | P01555 | |
| SMR | P01555 | |
| DIP | DIP-6255N | |
| IntAct | P01555 | |
| STRING | 243277.VC1457 | |
| DNASU | 2613963 | |
| EnsemblBacteria | AAF94614 | |
| GeneID | 2613963 | |
| KEGG | vch:VC1457 | |
| PATRIC | 20081976 | |
| eggNOG | NOG262323 | |
| KO | K10928 | |
| OMA | NITFIFF | |
| OrthoDB | EOG6GXTN0 | |
| BioCyc | VCHO:VC1457-MONOMER | |
| EvolutionaryTrace | P01555 | |
| PRO | PR:P01555 | |
| Proteomes | UP000000584 | |
| GO | GO:0005576 GO:0003950 GO:0031640 GO:0009405 GO:0030819 GO:0042517 GO:0006471 | |
| InterPro | IPR001144 | |
| Pfam | PF01375 | |
| PRINTS | PR00771 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
ECO:0000314 |
P |
Figure 2 (A) Shows Cholera elevates the levels of phosphorylation in STAT3 over time. |
complete | |||||
|
enables |
GO:0005534 |
galactose binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1902494 |
catalytic complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042597 |
periplasmic space |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006471 |
protein ADP-ribosylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003950 |
NAD+ ADP-ribosyltransferase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090729 |
toxin activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090729 |
toxin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Shu, M et al. (2011) Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells. Mol Oncol 5 265-72 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 O'Neal, CJ et al. (2004) Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism. Biochemistry 43 3772-82 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Mekalanos, JJ et al. () Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development. Nature 306 551-7 PubMed GONUTS page
