PMID:3093892

Citation	Jones, NH, Clabby, ML, Dialynas, DP, Huang, HJ, Herzenberg, LA and Strominger, JL Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1. Nature 323:346-9
Abstract	The T1/Leu-1/CD5 molecule, a human T-cell surface glycoprotein of relative molecular mass (Mr) 67,000, has been implicated in the proliferative response of activated T cells and in T-cell helper function. A similar involvement in T-cell proliferation has been reported for Ly-1, the murine homologue of T1. Here we report the complete amino-acid sequence of the T1 precursor molecule deduced from complementary DNA clones. The protein contains a classical signal peptide; a 347-amino-acid extracellular segment; a transmembrane region; and a 93-amino-acid intracellular segment. The extracellular segment contains many cysteine residues and is composed of two related structural domains separated by a proline/threonine-rich region. The T1 molecule has structural features characteristic of other receptor molecules.
Links	PubMed Online version:10.1038/323346a0
Keywords	Amino Acid Sequence; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface/genetics; Base Sequence; Cloning, Molecular; Cysteine/analysis; DNA/genetics; Glycoproteins/genetics; Humans; Membrane Proteins/genetics; Molecular Weight; Phosphoproteins/genetics; Protein Sorting Signals/genetics; RNA, Messenger/genetics; Receptors, Immunologic/genetics; T-Lymphocytes/physiology
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Significance

Gene product	Qualifier	GO Term	Evidence Code	Aspect	Notes	Status
HUMAN:CD5	enables	GO:0004888: transmembrane signaling receptor activity	ECO:0000303: author statement without traceable support used in manual assertion	F	Seeded From UniProt	complete
HUMAN:CD5	involved_in	GO:0008283: cell population proliferation	ECO:0000303: author statement without traceable support used in manual assertion	P	Seeded From UniProt	complete

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