PMID:28283184

Citation	Zhang, F, Li, S, Song, J, Liu, J, Cui, Y and Chen, H' (2017) Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells. Atherosclerosis '
Abstract	Angiotensin II (Ang II) is a bioactive peptide that is related to cardiovascular disease such as atherosclerosis, whereas angiotensin-(1-7) (Ang-(1-7)) is a counter-regulator of angiotensin II, which protects against cardiovascular disease. Matrix metalloproteinase 8 (MMP-8) is thought to participate in plaque destabilization though degradation of extracellular matrix, improving the development of atherosclerosis. Whether Ang-(1-7) modulates Ang II-induced MMP-8 remains unclear. In this study, we investigated the effect of Ang-(1-7) on Ang II-induced MMP-8 expression in smooth muscle cells.
Links	PubMed Online version:10.1016/j.atherosclerosis.2017.02.012
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:ANGT		GO:0000187: activation of MAPK activity	ECO:0000315:		P		Organism: Homo sapiens. Protein Name: Angiotensin II (Ang II). Notes: Figure 4A is used. As the paper states, the researchers "found an increase in phosphorylation of p38 MAPK when SMCs were treated with Ang II." The chart indeed shows that MAPK levels nearly multiply by three when cells are treated with Ang II. Thus, the increase in MMP-8 levels discussed in the paper is likely due to an activation of MAPK activity. Ang II shares a UniProt page with Ang-(1-7), even though the two are different entities.	complete CACAO 12355
HUMAN:ANGT		GO:0043407: negative regulation of MAP kinase activity	ECO:0000315:		P		Organism: Homo sapiens. Protein Name: Angiotensin-(1-7) (Ang-(1-7)). Notes: Figure 4A is used. As the paper states, “the activation of p38 MAPK induced by Ang II was counter-regulated by Ang-(1-7). The MAS receptor antagonist A779 blocked the inhibitory effect of Ang-(1-7) on Ang II-induced p38 MAPK activation.” To be clear, Ang-(1-7) needs the MAS receptor to inhibit the effects Ang II, which explains the effect of the A779 receptor antagonist. The chart indeed shows that MAPK levels decrease by a factor of *NEARLY* two when cells are treated with Ang II and Ang-(1-7) as opposed to just Ang II. Thus, the decrease in MMP-8 levels discussed in the paper (when cells are treated with both proteins as opposed to just Ang II) is likely due to a decrease in MAPK activity. Ang-(1-7) shares a UniProt page with Ang II, even though the two are different entities.	complete CACAO 12356

References

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