HUMAN:ANGT

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AGT (synonyms: SERPINA8)
Protein Name(s)	Angiotensinogen Serpin A8 Angiotensin-1 Angiotensin 1-10 Angiotensin I Ang I Angiotensin-2 Angiotensin 1-8 Angiotensin II Ang II Angiotensin-3 Angiotensin 2-8 Angiotensin III Ang III Des-Asp[1]-angiotensin II Angiotensin-4 Angiotensin 3-8 Angiotensin IV Ang IV Angiotensin 1-9 Angiotensin 1-7 Angiotensin 1-5 Angiotensin 1-4
External Links
UniProt	P01019
EMBL	K02215 M24689 M24686 M24687 M24688 X15324 X15325 X15326 X15327 BC011519 M69110 S78529 S78530
CCDS	CCDS1585.1
PIR	A35203
RefSeq	NP_000020.1
UniGene	Hs.19383
PDB	1N9U 1N9V 2JP8 2WXW 2X0B 3CK0 3WOO 3WOR 4AA1 4APH 4FYS
PDBsum	1N9U 1N9V 2JP8 2WXW 2X0B 3CK0 3WOO 3WOR 4AA1 4APH 4FYS
ProteinModelPortal	P01019
SMR	P01019
BioGrid	106690
DIP	DIP-309N
IntAct	P01019
MINT	MINT-1472115
STRING	9606.ENSP00000355627
MEROPS	I04.953
PhosphoSite	P01019
DMDM	113880
SWISS-2DPAGE	P01019
MaxQB	P01019
PaxDb	P01019
PeptideAtlas	P01019
PRIDE	P01019
DNASU	183
Ensembl	ENST00000366667
GeneID	183
KEGG	hsa:183
UCSC	uc001hty.4
CTD	183
GeneCards	GC01M230838
HGNC	HGNC:333
HPA	HPA001557
MIM	106150 145500 267430
neXtProt	NX_P01019
Orphanet	243761 97369
PharmGKB	PA42
eggNOG	NOG314543
GeneTree	ENSGT00750000117773
HOVERGEN	HBG004233
InParanoid	P01019
KO	K09821
OMA	RFMQAVT
OrthoDB	EOG7QK0BN
PhylomeDB	P01019
TreeFam	TF343201
Reactome	REACT_116145 REACT_147707 REACT_14819 REACT_18283 REACT_19231
ChiTaRS	AGT
EvolutionaryTrace	P01019
GeneWiki	Angiotensin
GenomeRNAi	183
NextBio	748
PMAP-CutDB	P01019
PRO	PR:P01019
Proteomes	UP000005640
Bgee	P01019
CleanEx	HS_AGT
ExpressionAtlas	P01019
Genevestigator	P01019
GO	GO:0072562 GO:0005737 GO:0005576 GO:0005615 GO:0070062 GO:0008083 GO:0005179 GO:0004867 GO:0016176 GO:0031702 GO:0031703 GO:0007250 GO:0007202 GO:0007568 GO:0002003 GO:0001998 GO:0003051 GO:0014824 GO:0048143 GO:0001568 GO:0001974 GO:0001658 GO:0035411 GO:0061049 GO:0007267 GO:0007160 GO:0044255 GO:0044267 GO:0071260 GO:0006883 GO:0050663 GO:0070371 GO:0008065 GO:0007588 GO:0030198 GO:0007565 GO:0048144 GO:0007186 GO:0007199 GO:0001822 GO:0034374 GO:0016525 GO:0030308 GO:0008285 GO:0010951 GO:0043524 GO:0051387 GO:2000650 GO:0034104 GO:0007263 GO:0001543 GO:0030432 GO:0007200 GO:0010535 GO:0090190 GO:0010613 GO:0032270 GO:0010873 GO:0001819 GO:0010595 GO:0045742 GO:0003331 GO:2001238 GO:0045723 GO:0048146 GO:0050729 GO:0010744 GO:0043410 GO:0040018 GO:0033864 GO:0051092 GO:0045429 GO:0046622 GO:0050731 GO:0014068 GO:0061098 GO:2000379 GO:0035815 GO:0032930 GO:0045893 GO:0045909 GO:0002034 GO:0002016 GO:0051924 GO:0001558 GO:0042127 GO:0048169 GO:0014061 GO:0030162 GO:0002019 GO:0035813 GO:0051969 GO:0019229 GO:0001999 GO:0003014 GO:0002018 GO:0009409 GO:0014873 GO:0009651 GO:0044281 GO:0051145 GO:0048659 GO:0051403 GO:0070471 GO:0042311
InterPro	IPR000227 IPR023795 IPR023796 IPR000215
PANTHER	PTHR11461
Pfam	PF00079
PRINTS	PR00654
SMART	SM00093
SUPFAM	SSF56574
PROSITE	PS00284

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:1903779	regulation of cardiac conduction	PMID:17416596^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P00797	P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	PMID:17416596^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P00797	P		Seeded From UniProt	complete
involved_in	GO:1901201	regulation of extracellular matrix assembly	PMID:17416596^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P00797	P	has_input:(UniProtKB:P02751)	Seeded From UniProt	complete
involved_in	GO:1903598	positive regulation of gap junction assembly	PMID:17416596^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P00797	P	has_input:(UniProtKB:P17302)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
involved_in	GO:0003014	renal system process	PMID:21183621^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PMID:10406457^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	PMID:10406457^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:15652490^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01015	P		Seeded From UniProt	complete
involved_in	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	PMID:15652490^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:17159080^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035813	regulation of renal sodium excretion	PMID:17159080^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034374	low-density lipoprotein particle remodeling	PMID:17069818^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	PMID:18971559^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031703	type 2 angiotensin receptor binding	PMID:10406457^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50052	F		Seeded From UniProt	complete
enables	GO:0031702	type 1 angiotensin receptor binding	PMID:1378723^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P30556	F		Seeded From UniProt	complete
involved_in	GO:0019229	regulation of vasoconstriction	PMID:17159080^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014873	response to muscle activity involved in regulation of muscle adaptation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01015	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:15652490^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010873	positive regulation of cholesterol esterification	PMID:18971559^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PMID:18971559^[12]	ECO:0000305	curator inference used in manual assertion	GO:0010873	P		Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01015	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:15652490^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	PMID:17159080^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:10406457^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18971559^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:1378723^[13]	ECO:0000305	curator inference used in manual assertion	GO:0031702	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01015	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:1378723^[13]	ECO:0000305	curator inference used in manual assertion	GO:0031702	F		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01015	F		Seeded From UniProt	complete
involved_in	GO:0002019	regulation of renal output by angiotensin	PMID:17159080^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002018	renin-angiotensin regulation of aldosterone production	PMID:17159080^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002016	regulation of blood volume by renin-angiotensin	PMID:17159080^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:16116425^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001558	regulation of cell growth	PMID:17159080^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:18607644^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:15153556^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15153556^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18607644^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0000187	activation of MAPK activity	PMID:28283184^[17]	ECO:0000315			P		Organism: Homo sapiens. Protein Name: Angiotensin II (Ang II). Notes: Figure 4A is used. As the paper states, the researchers "found an increase in phosphorylation of p38 MAPK when SMCs were treated with Ang II." The chart indeed shows that MAPK levels nearly multiply by three when cells are treated with Ang II. Thus, the increase in MMP-8 levels discussed in the paper is likely due to an activation of MAPK activity. Ang II shares a UniProt page with Ang-(1-7), even though the two are different entities.	complete CACAO 12355
involved_in	GO:0010536	positive regulation of activation of Janus kinase activity	PMID:15153556^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0043407	negative regulation of MAP kinase activity	PMID:28283184^[17]	ECO:0000315			P		Organism: Homo sapiens. Protein Name: Angiotensin-(1-7) (Ang-(1-7)). Notes: Figure 4A is used. As the paper states, “the activation of p38 MAPK induced by Ang II was counter-regulated by Ang-(1-7). The MAS receptor antagonist A779 blocked the inhibitory effect of Ang-(1-7) on Ang II-induced p38 MAPK activation.” To be clear, Ang-(1-7) needs the MAS receptor to inhibit the effects Ang II, which explains the effect of the A779 receptor antagonist. The chart indeed shows that MAPK levels decrease by a factor of NEARLY two when cells are treated with Ang II and Ang-(1-7) as opposed to just Ang II. Thus, the decrease in MMP-8 levels discussed in the paper (when cells are treated with both proteins as opposed to just Ang II) is likely due to a decrease in MAPK activity. Ang-(1-7) shares a UniProt page with Ang II, even though the two are different entities.	complete CACAO 12356
part_of	GO:0005576	extracellular region	PMID:14718574^[18]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028988 FB:FBgn0265137 PANTHER:PTN000156123 RGD:3249 UniProtKB:P05121 UniProtKB:P29508 UniProtKB:P35237 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q9UIV8	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0015586 FB:FBgn0028986 FB:FBgn0031973 FB:FBgn0262057 FB:FBgn0265137 MGI:MGI:108080 MGI:MGI:1915304 MGI:MGI:87963 MGI:MGI:88278 MGI:MGI:894696 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:2069 RGD:3249 RGD:3326 RGD:3747 RGD:3748 RGD:619833 RGD:631369 RGD:735225 UniProtKB:P01008 UniProtKB:P01009 UniProtKB:P01011 UniProtKB:P01019 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P08697 UniProtKB:P50453 UniProtKB:Q90935 UniProtKB:Q99574 UniProtKB:Q9TTE1	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0028983 FB:FBgn0028988 FB:FBgn0028990 FB:FBgn0265137 MGI:MGI:101780 MGI:MGI:106603 MGI:MGI:1277952 MGI:MGI:2445361 MGI:MGI:2683293 MGI:MGI:891970 MGI:MGI:894696 MGI:MGI:97608 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:3249 RGD:3326 RGD:3748 RGD:619817 RGD:619896 RGD:619897 UniProtKB:P01009 UniProtKB:P01012 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P05155 UniProtKB:P07093 UniProtKB:P08697 UniProtKB:P35237 UniProtKB:P48594 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q3ZEJ6 UniProtKB:Q86WD7 UniProtKB:Q90935 UniProtKB:Q96P63 UniProtKB:Q99574 UniProtKB:Q9TTE1 UniProtKB:Q9UIV8 WB:WBGene00005643	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:1905589	positive regulation of L-arginine import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:1905010	positive regulation of L-lysine import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:1904385	cellular response to angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0070471	uterine smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0061049	cell growth involved in cardiac muscle cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0051969	regulation of transmission of nerve impulse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0050663	cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0048659	smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0048144	fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0045777	positive regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0042311	vasodilation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0035815	positive regulation of renal sodium excretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0035813	regulation of renal sodium excretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0035106	operant conditioning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0034104	negative regulation of tissue remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0014873	response to muscle activity involved in regulation of muscle adaptation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0014824	artery smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0014061	regulation of norepinephrine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0007202	activation of phospholipase C activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0006883	cellular sodium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	F		Seeded From UniProt	complete
involved_in	GO:0003331	positive regulation of extracellular matrix constituent secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0003051	angiotensin-mediated drinking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0002027	regulation of heart rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0002018	renin-angiotensin regulation of aldosterone production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01015 ensembl:ENSRNOP00000024917	P		Seeded From UniProt	complete
involved_in	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000227 InterPro:IPR033834	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000215	C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24296617^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000118523) occurs_in:(CL:0000746) occurs_in:(UBERON:0007221)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:24296617^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(RNAcentral:URS000013D17D_9606) occurs_in:(CL:0000746) occurs_in:(UBERON:0007221)	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:24296617^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0038166)	Seeded From UniProt	complete
involved_in	GO:0038166	angiotensin-activated signaling pathway	PMID:24296617^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0045893) occurs_in:(CL:0000746) occurs_in:(UBERON:0007221)	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:15803439^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:1902632	positive regulation of membrane hyperpolarization	PMID:15803439^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002080)	Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:17703433^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:1902632	positive regulation of membrane hyperpolarization	PMID:17703433^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000746) occurs_in:(UBERON:0002080)	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:8513325^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:3397061^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:17906677^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:17906677^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:17159080^[10] PMID:17906677^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033864	positive regulation of NAD(P)H oxidase activity	PMID:17159080^[10] PMID:19193863^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:10406457^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	PMID:17159080^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007199	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	PMID:17159080^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002034	regulation of blood vessel diameter by renin-angiotensin	PMID:10406457^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	PMID:10406457^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	PMID:17906677^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	Reactome:R-HSA-400206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8851929	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-2022369 Reactome:R-HSA-9615348 Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-380073 Reactome:R-HSA-379048 Reactome:R-HSA-374173 Reactome:R-HSA-2065357 Reactome:R-HSA-2065355 Reactome:R-HSA-2028294 Reactome:R-HSA-2022412 Reactome:R-HSA-2022411 Reactome:R-HSA-2022405 Reactome:R-HSA-2022403 Reactome:R-HSA-2022399 Reactome:R-HSA-2022398 Reactome:R-HSA-2022396 Reactome:R-HSA-2022383 Reactome:R-HSA-2022381 Reactome:R-HSA-2022379 Reactome:R-HSA-2022378 Reactome:R-HSA-2022368 Reactome:R-HSA-1989774	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0839	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0050880	regulation of blood vessel size	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0838	P		Seeded From UniProt	complete
enables	GO:0016176	superoxide-generating NADPH oxidase activator activity	PMID:19193863^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	PMID:19193863^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Fischer, R et al. (2007) Angiotensin II-induced sudden arrhythmic death and electrical remodeling. Am. J. Physiol. Heart Circ. Physiol. 293 H1242-53 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ Butte, AJ et al. (2011) Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease. Mol. Cell Proteomics 10 M110.000497 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Lehtonen, JY et al. (1999) Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis. Mol. Endocrinol. 13 1051-60 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Montiel, M et al. (2005) Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 327 971-8 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Hernandez Schulman, I et al. (2007) Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans. Hypertension 49 270-1 PubMed GONUTS page
↑ Luchtefeld, M et al. (2007) Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation. Atherosclerosis 194 62-70 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Kanome, T et al. (2008) Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages. Hypertens. Res. 31 1801-10 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Mauzy, CA et al. (1992) Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor. Biochem. Biophys. Res. Commun. 186 277-84 PubMed GONUTS page
↑ Gribouval, O et al. (2005) Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat. Genet. 37 964-8 PubMed GONUTS page
↑ ^15.0 ^15.1 Chen, YW et al. (2008) Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis. Pediatr. Nephrol. 23 1769-77 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Zhang, SL et al. (2004) Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. J. Am. Soc. Nephrol. 15 1452-65 PubMed GONUTS page
↑ ^17.0 ^17.1 Zhang, F et al. (2017) Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells. Atherosclerosis PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Gao, S et al. (2014) Downregulation of microRNA-19b contributes to angiotensin II-induced overexpression of connective tissue growth factor in cardiomyocytes. Cardiology 127 114-20 PubMed GONUTS page
↑ ^21.0 ^21.1 De Mello, WC (2004) Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump. J Renin Angiotensin Aldosterone Syst 5 203-8 PubMed GONUTS page
↑ ^22.0 ^22.1 De Mello, WC et al. (2007) Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart. J Renin Angiotensin Aldosterone Syst 8 74-80 PubMed GONUTS page
↑ Ward, K et al. (1993) A molecular variant of angiotensinogen associated with preeclampsia. Nat. Genet. 4 59-61 PubMed GONUTS page
↑ Clouston, WM et al. (1988) Molecular cloning of the mouse angiotensinogen gene. Genomics 2 240-8 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Zhong, JC et al. (2008) Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression. Br. J. Pharmacol. 153 66-74 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 White, CN et al. (2009) Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. Am. J. Physiol., Cell Physiol. 296 C693-700 PubMed GONUTS page

[PMID:25037231-1] Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:27068509-2] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:17416596-3] 3.0 ^3.1 ^3.2 ^3.3 Fischer, R et al. (2007) Angiotensin II-induced sudden arrhythmic death and electrical remodeling. Am. J. Physiol. Heart Circ. Physiol. 293 H1242-53 PubMed GONUTS page

[PMID:23533145-4] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:22516433-5] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:16502470-6] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:21183621-7] Butte, AJ et al. (2011) Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease. Mol. Cell Proteomics 10 M110.000497 PubMed GONUTS page

[PMID:10406457-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Lehtonen, JY et al. (1999) Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis. Mol. Endocrinol. 13 1051-60 PubMed GONUTS page

[PMID:15652490-9] 9.0 ^9.1 ^9.2 ^9.3 Montiel, M et al. (2005) Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 327 971-8 PubMed GONUTS page

[PMID:17159080-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Hernandez Schulman, I et al. (2007) Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans. Hypertension 49 270-1 PubMed GONUTS page

[PMID:17069818-11] Luchtefeld, M et al. (2007) Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation. Atherosclerosis 194 62-70 PubMed GONUTS page

[PMID:18971559-12] 12.0 ^12.1 ^12.2 ^12.3 Kanome, T et al. (2008) Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages. Hypertens. Res. 31 1801-10 PubMed GONUTS page

[PMID:1378723-13] 13.0 ^13.1 ^13.2 Mauzy, CA et al. (1992) Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor. Biochem. Biophys. Res. Commun. 186 277-84 PubMed GONUTS page

[PMID:16116425-14] Gribouval, O et al. (2005) Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat. Genet. 37 964-8 PubMed GONUTS page

[PMID:18607644-15] 15.0 ^15.1 Chen, YW et al. (2008) Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis. Pediatr. Nephrol. 23 1769-77 PubMed GONUTS page

[PMID:15153556-16] 16.0 ^16.1 ^16.2 Zhang, SL et al. (2004) Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. J. Am. Soc. Nephrol. 15 1452-65 PubMed GONUTS page

[PMID:28283184-17] 17.0 ^17.1 Zhang, F et al. (2017) Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells. Atherosclerosis PubMed GONUTS page

[PMID:14718574-18] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24296617-20] 20.0 ^20.1 ^20.2 ^20.3 Gao, S et al. (2014) Downregulation of microRNA-19b contributes to angiotensin II-induced overexpression of connective tissue growth factor in cardiomyocytes. Cardiology 127 114-20 PubMed GONUTS page

[PMID:15803439-21] 21.0 ^21.1 De Mello, WC (2004) Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump. J Renin Angiotensin Aldosterone Syst 5 203-8 PubMed GONUTS page

[PMID:17703433-22] 22.0 ^22.1 De Mello, WC et al. (2007) Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart. J Renin Angiotensin Aldosterone Syst 8 74-80 PubMed GONUTS page

[PMID:8513325-23] Ward, K et al. (1993) A molecular variant of angiotensinogen associated with preeclampsia. Nat. Genet. 4 59-61 PubMed GONUTS page

[PMID:3397061-24] Clouston, WM et al. (1988) Molecular cloning of the mouse angiotensinogen gene. Genomics 2 240-8 PubMed GONUTS page

[PMID:17906677-25] 25.0 ^25.1 ^25.2 ^25.3 Zhong, JC et al. (2008) Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression. Br. J. Pharmacol. 153 66-74 PubMed GONUTS page

[PMID:19193863-26] 26.0 ^26.1 ^26.2 White, CN et al. (2009) Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. Am. J. Physiol., Cell Physiol. 296 C693-700 PubMed GONUTS page

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