GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:28146073
| Citation |
Rizzacasa, B, Morini, E, Pucci, S, Murdocca, M, Novelli, G and Amati, F (2017) LOX-1 and Its Splice Variants: A New Challenge for Atherosclerosis and Cancer-Targeted Therapies. Int J Mol Sci 18 |
|---|---|
| Abstract |
Alternative splicing (AS) is a process in which precursor messenger RNA (pre-mRNA) splicing sites are differentially selected to diversify the protein isoform population. Changes in AS patterns have an essential role in normal development, differentiation and response to physiological stimuli. It is documented that AS can generate both "risk" and "protective" splice variants that can contribute to the pathogenesis of several diseases including atherosclerosis. The main endothelial receptor for oxidized low-density lipoprotein (ox-LDLs) is LOX-1 receptor protein encoded by the OLR1 gene. When OLR1 undergoes AS events, it generates three variants: OLR1, OLR1D4 and LOXIN. The latter lacks exon 5 and two-thirds of the functional domain. Literature data demonstrate a protective role of LOXIN in pathologies correlated with LOX-1 overexpression such as atherosclerosis and tumors. In this review, we summarize recent developments in understanding of OLR1 AS while also highlighting data warranting further investigation of this process as a novel therapeutic target. |
| Links |
PubMed PMC5343826 Online version:10.3390/ijms18020290 |
| Keywords |
Alternative Splicing; Animals; Atherosclerosis/genetics; Atherosclerosis/metabolism; Atherosclerosis/therapy; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/metabolism; Gene Expression Regulation/drug effects; Genetic Predisposition to Disease; Humans; Molecular Targeted Therapy; Neoplasms/genetics; Neoplasms/metabolism; Neoplasms/therapy; Protein Isoforms; RNA Splicing; RNA, Messenger/genetics; Scavenger Receptors, Class E/chemistry; Scavenger Receptors, Class E/genetics; Scavenger Receptors, Class E/metabolism; Signal Transduction/drug effects |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002376: immune system process |
ECO:0000315: |
P |
Expression of lipoprotein receptors during inflammatory cascade. |
complete | ||||
Notes
See also
References
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