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HUMAN:OLR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) OLR1 (synonyms: CLEC8A, LOX1)
Protein Name(s) Oxidized low-density lipoprotein receptor 1

Ox-LDL receptor 1 C-type lectin domain family 8 member A Lectin-like oxidized LDL receptor 1 LOX-1 Lectin-like oxLDL receptor 1 hLOX-1 Lectin-type oxidized LDL receptor 1 Oxidized low-density lipoprotein receptor 1, soluble form

External Links
UniProt P78380
EMBL AB010710
AF035776
AF079167
AF079166
AF079164
AF079165
AB102861
AJ131757
BX344276
AK292124
AK295409
DQ314885
AC024224
CH471094
CH471094
BC022295
CCDS CCDS53745.1
CCDS53746.1
CCDS8618.1
RefSeq NP_001166103.1
NP_001166104.1
NP_002534.1
XP_011518984.1
UniGene Hs.412484
PDB 1YPO
1YPQ
1YPU
1YXJ
1YXK
3VLG
PDBsum 1YPO
1YPQ
1YPU
1YXJ
1YXK
3VLG
ProteinModelPortal P78380
SMR P78380
BioGrid 111021
DIP DIP-42040N
IntAct P78380
MINT MINT-1343572
STRING 9606.ENSP00000309124
BioMuta OLR1
DMDM 73621335
MaxQB P78380
PaxDb P78380
PRIDE P78380
DNASU 4973
Ensembl ENST00000309539
ENST00000432556
ENST00000545927
GeneID 4973
KEGG hsa:4973
UCSC uc001qxo.1
uc010sha.1
uc021qvb.1
CTD 4973
GeneCards OLR1
HGNC HGNC:8133
HPA HPA050798
MIM 602601
neXtProt NX_P78380
PharmGKB PA31920
eggNOG NOG242244
GeneTree ENSGT00700000104266
HOGENOM HOG000220927
HOVERGEN HBG056863
InParanoid P78380
KO K08763
OMA QQANLTH
OrthoDB EOG747PJT
PhylomeDB P78380
TreeFam TF336674
Reactome R-HSA-202733
ChiTaRS OLR1
EvolutionaryTrace P78380
GeneWiki OLR1
GenomeRNAi 4973
NextBio 19142
PMAP-CutDB P78380
PRO PR:P78380
Proteomes UP000005640
Bgee P78380
CleanEx HS_OLR1
ExpressionAtlas P78380
Genevisible P78380
GO GO:0070062
GO:0005887
GO:0043231
GO:0016020
GO:0045121
GO:0005654
GO:0005886
GO:0043235
GO:0030246
GO:0005041
GO:0008015
GO:0007596
GO:0007155
GO:0006954
GO:0050900
GO:0006508
Gene3D 3.10.100.10
InterPro IPR001304
IPR016186
IPR016187
IPR013600
Pfam PF00059
PF08391
SMART SM00034
SUPFAM SSF56436
PROSITE PS50041

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0043235

receptor complex

PMID:23382219[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:19664054[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P78380

F

Seeded From UniProt

complete

GO:0006954

inflammatory response

PMID:26385009[3]

ECO:0000255

UniProtKB:P78380


P

Figure 1. shows the role of LOX-1 in atherosclerosis. OxLDL binds to LOX-1 on the endothelial cell surface triggering activation of an inflammatory reaction.

complete
CACAO 11139

GO:0002376

immune system process

PMID:28146073[4]

ECO:0000315

P

Expression of lipoprotein receptors during inflammatory cascade.

complete
CACAO 12805

enables

GO:0042802

identical protein binding

PMID:15939022[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P78380

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:9052782[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008015

blood circulation

PMID:9052782[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:9052782[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:9052782[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070821

tertiary granule membrane

Reactome:R-HSA-6798747

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

Reactome:R-HSA-202733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035579

specific granule membrane

Reactome:R-HSA-6799350

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-6799350
Reactome:R-HSA-6798747
Reactome:R-HSA-203130

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0430

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0370

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
  2. ↑ Cao, W et al. (2009) Oligomerization is required for the activity of recombinant soluble LOX-1. FEBS J. 276 4909-20 PubMed GONUTS page
  3. ↑ De Siqueira, J et al. (2015) Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics. J Cardiovasc Transl Res 8 458-65 PubMed GONUTS page
  4. ↑ Rizzacasa, B et al. (2017) LOX-1 and Its Splice Variants: A New Challenge for Atherosclerosis and Cancer-Targeted Therapies. Int J Mol Sci 18 PubMed GONUTS page
  5. ↑ Ohki, I et al. (2005) Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL. Structure 13 905-17 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Sawamura, T et al. (1997) An endothelial receptor for oxidized low-density lipoprotein. Nature 386 73-7 PubMed GONUTS page
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