PMID:2684108

Citation	Van Huynh, T, Cole, G, Katzman, R, Huang, KP and Saitoh, T (1989) Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts. Arch. Neurol. 46:1195-9
Abstract	Abnormal protein kinase C levels and protein kinase C-dependent phosphorylation are biochemical alterations in brain tissue obtained from patients with Alzheimer's disease. Because many biochemical and biophysical abnormalities are found in peripheral tissues of patients with Alzheimer's disease, we studied protein kinase C levels and the in vitro phosphorylation of proteins under protein kinase C-activating conditions in fibroblasts derived from patients with Alzheimer's disease. The concentration of protein kinase C-like immunoreactivity was reduced in Alzheimer's disease samples, although the protein kinase C activity determined by the phosphorylation of exogenous histone was not. The degree of in vitro phosphorylation of an Mr 79,000 protein in the presence of protein kinase C activators was less in Alzheimer's disease than in control fibroblast cytosol, and a reduction was more prominent in cases of familial Alzheimer's disease than in sporadic Alzheimer's disease. Therefore, the aberrant phosphorylation mediated by protein kinase C is found not only in the brain but also in fibroblasts.
Links	PubMed
Keywords	Alzheimer Disease/enzymology; Alzheimer Disease/metabolism; Fibroblasts/enzymology; Fibroblasts/metabolism; Humans; Immunologic Techniques; Phosphoproteins; Phosphorylation; Protein Kinase C/metabolism; Proteins/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:IL8		GO:0001525: angiogenesis	ECO:0000314:		P		Figure 5 show that CXCL8 effect that blood vessel formation and that different concentration have different effects on angiogenesis.	complete CACAO 5627
HUMAN:IL8		GO:0008283: cell proliferation	ECO:0000314:		P		Figure 3 shows that with different concentration of CXCL8 effects the overall cell proliferation.	complete CACAO 5622
HUMAN:SDF1		GO:0008283: cell proliferation	ECO:0000314:		P		Figure 3 shows that the different concentration of CXCL12 effect the overall proliferation of the cell.	complete CACAO 5626
HUMAN:SDF1		GO:0042148: strand invasion	ECO:0000314:		P		Figure 6 shows that from the data collected, CXCL12 invades tumor cells and will cause the formation of CXCL8 products.	complete CACAO 5629

References

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