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PMID:21029458
| Citation |
Zhang, W, Murao, K, Zhang, X, Matsumoto, K, Diah, S, Okada, M, Miyake, K, Kawai, N, Fei, Z and Tamiya, T (2010) Resveratrol represses YKL-40 expression in human glioma U87 cells. BMC Cancer 10:593 |
|---|---|
| Abstract |
Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-expressed genes in these tumours but not in normal brain tissue. Clinical studies have shown that serum YKL-40 levels are positively correlated with tumour burden in addition to being an independent prognostic factor of a short relapse-free interval as well as short overall survival in patients with various cancers. Our previous study revealed that YKL-40 was closely correlated with the pathological grades of human primary astrocytomas and played a crucial role in glioma cell proliferation. Hence, YKL-40 could be an attractive target in the design of anti-cancer therapies. |
| Links |
PubMed PMC2988030 Online version:10.1186/1471-2407-10-593 |
| Keywords |
Adipokines; Antineoplastic Agents, Phytogenic/pharmacology; Brain Neoplasms/drug therapy; Brain Neoplasms/metabolism; Cell Line, Tumor; Cell Proliferation; Cell Survival; Culture Media/metabolism; Disease-Free Survival; Gene Expression Regulation, Neoplastic; Glioma/drug therapy; Glioma/metabolism; Glycoproteins/biosynthesis; Humans; Lectins/biosynthesis; Prognosis; Promoter Regions, Genetic; Recurrence; Stilbenes/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003674: molecular function |
ECO:0000314: |
F |
Figure 2: The ratio of invading cells decreased significantly in both Res- and siRNA-pretreated U87 cells. |
complete | ||||
|
enables |
GO:0004707: MAP kinase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0004707: MAP kinase activity |
ECO:0000314: |
F |
Figure 4: ERK1/2 pathway involvement in the Res-induced repression of YKL-40 expression. |
complete | ||||
See also
References
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