HUMAN:CH3L1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CHI3L1
Protein Name(s)	Chitinase-3-like protein 1 39 kDa synovial protein Cartilage glycoprotein 39 CGP-39 GP-39 hCGP-39 YKL-40
External Links
UniProt	P36222
EMBL	M80927 Y08374 Y08375 Y08376 Y08377 Y08378 BT007223 AK312911 CH471067 BC008568 BC038354 BC039132
CCDS	CCDS1435.1
PIR	A49562
RefSeq	NP_001267.2
UniGene	Hs.382202 Hs.733359
PDB	1HJV 1HJW 1HJX 1LA7 1NWR 1NWS 1NWT 1NWU
PDBsum	1HJV 1HJW 1HJX 1LA7 1NWR 1NWS 1NWT 1NWU
ProteinModelPortal	P36222
SMR	P36222
BioGrid	107540
STRING	9606.ENSP00000255409
CAZy	GH18
PhosphoSite	P36222
DMDM	84028186
PaxDb	P36222
PeptideAtlas	P36222
PRIDE	P36222
DNASU	1116
Ensembl	ENST00000255409
GeneID	1116
KEGG	hsa:1116
UCSC	uc001gzi.2
CTD	1116
GeneCards	GC01M203148
HGNC	HGNC:1932
MIM	601525 611960
neXtProt	NX_P36222
PharmGKB	PA26463
eggNOG	COG3325
GeneTree	ENSGT00550000074323
HOGENOM	HOG000111109
HOVERGEN	HBG011684
InParanoid	P36222
KO	K17523
OMA	FEPGHES
OrthoDB	EOG7ZGX3G
PhylomeDB	P36222
TreeFam	TF315610
ChiTaRS	CHI3L1
EvolutionaryTrace	P36222
GeneWiki	CHI3L1
GenomeRNAi	1116
NextBio	4626
PRO	PR:P36222
Proteomes	UP000005640
Bgee	P36222
CleanEx	HS_CHI3L1
ExpressionAtlas	P36222
Genevestigator	P36222
GO	GO:0005737 GO:0005783 GO:0005615 GO:0070062 GO:0048471 GO:0005578 GO:0030246 GO:0008061 GO:0005201 GO:0004553 GO:0007250 GO:0006915 GO:0005975 GO:0051216 GO:0071356 GO:0006032 GO:0006954 GO:0072606 GO:0030324 GO:0045766 GO:0070374 GO:0010800 GO:0051897 GO:0070555 GO:0070741 GO:0009612 GO:0034612
Gene3D	3.10.50.10 3.20.20.80
InterPro	IPR028538 IPR011583 IPR029070 IPR001223 IPR013781 IPR017853
PANTHER	PTHR11177:SF81
Pfam	PF00704
SMART	SM00636
SUPFAM	SSF51445 SSF54556

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003674	molecular function	PMID:21029458^[1]	ECO:0000314			F		Figure 2: The ratio of invading cells decreased significantly in both Res- and siRNA-pretreated U87 cells.	complete CACAO 2457
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
involved_in	GO:0072606	interleukin-8 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61362	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTV1	P		Seeded From UniProt	complete
involved_in	GO:0070741	response to interleukin-6	PMID:21478032^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	PMID:16234240^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21385870^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21385870^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:8245017^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21385870^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034612	response to tumor necrosis factor	PMID:16234240^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	PMID:18403759^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61362	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:20650887^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008061	chitin binding	PMID:12775711^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008061	chitin binding	PMID:9492324^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007250	activation of NF-kappaB-inducing kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61362	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:16234240^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61362	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61362	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9492324^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8245017^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000138)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:8245017^[7]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:8245017^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:0004568	chitinase activity	PMID:9492324^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:0004568	chitinase activity	PMID:8245017^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008061	chitin binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013763 FB:FBgn0022700 FB:FBgn0038180 PANTHER:PTN000126545 UniProtKB:P36222 UniProtKB:Q15782	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000126545 RGD:1303058 UniProtKB:C8VAA5	C		Seeded From UniProt	complete
involved_in	GO:0072606	interleukin-8 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61362 ensembl:ENSMUSP00000080717	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61362 ensembl:ENSMUSP00000080717	P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61362 ensembl:ENSMUSP00000080717	P		Seeded From UniProt	complete
involved_in	GO:0007250	activation of NF-kappaB-inducing kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61362 ensembl:ENSMUSP00000080717	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61362 ensembl:ENSMUSP00000080717	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61362 ensembl:ENSMUSP00000080717	C		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTV1 ensembl:ENSRNOP00000074871	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTV1 ensembl:ENSRNOP00000074871	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTV1 ensembl:ENSRNOP00000074871	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTV1 ensembl:ENSRNOP00000074871	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028538	C		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001223	P		Seeded From UniProt	complete
enables	GO:0008061	chitin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011583 InterPro:IPR028538	F		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028538	P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035580	specific granule lumen	Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhang, W et al. (2010) Resveratrol represses YKL-40 expression in human glioma U87 cells. BMC Cancer 10 593 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ Nielsen, AR et al. (2011) IL-6, but not TNF-α, increases plasma YKL-40 in human subjects. Cytokine 55 152-5 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Recklies, AD et al. (2005) Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. J. Biol. Chem. 280 41213-21 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Francescone, RA et al. (2011) Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. J. Biol. Chem. 286 15332-43 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Hakala, BE et al. (1993) Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J. Biol. Chem. 268 25803-10 PubMed GONUTS page
↑ Ober, C et al. (2008) Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N. Engl. J. Med. 358 1682-91 PubMed GONUTS page
↑ Park, JA et al. (2010) The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. J. Biol. Chem. 285 29817-25 PubMed GONUTS page
↑ Houston, DR et al. (2003) Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes. J. Biol. Chem. 278 30206-12 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Renkema, GH et al. (1998) Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. Eur. J. Biochem. 251 504-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21029458-1] Zhang, W et al. (2010) Resveratrol represses YKL-40 expression in human glioma U87 cells. BMC Cancer 10 593 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:16502470-3] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:21478032-4] Nielsen, AR et al. (2011) IL-6, but not TNF-α, increases plasma YKL-40 in human subjects. Cytokine 55 152-5 PubMed GONUTS page

[PMID:16234240-5] 5.0 ^5.1 ^5.2 Recklies, AD et al. (2005) Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. J. Biol. Chem. 280 41213-21 PubMed GONUTS page

[PMID:21385870-6] 6.0 ^6.1 ^6.2 Francescone, RA et al. (2011) Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. J. Biol. Chem. 286 15332-43 PubMed GONUTS page

[PMID:8245017-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Hakala, BE et al. (1993) Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J. Biol. Chem. 268 25803-10 PubMed GONUTS page

[PMID:18403759-8] Ober, C et al. (2008) Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N. Engl. J. Med. 358 1682-91 PubMed GONUTS page

[PMID:20650887-9] Park, JA et al. (2010) The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. J. Biol. Chem. 285 29817-25 PubMed GONUTS page

[PMID:12775711-10] Houston, DR et al. (2003) Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes. J. Biol. Chem. 278 30206-12 PubMed GONUTS page

[PMID:9492324-11] 11.0 ^11.1 ^11.2 Renkema, GH et al. (1998) Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. Eur. J. Biochem. 251 504-9 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:CH3L1

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References

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