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PMID:19258434
| Citation |
Hamada, S, Hara, K, Hamada, T, Yasuda, H, Moriyama, H, Nakayama, R, Nagata, M and Yokono, K (2009) Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia. Diabetes 58:1321-32 |
|---|---|
| Abstract |
Components of insulin/IGF-1 receptor-mediated signaling pathways in pancreatic beta-cells have been implicated in the development of diabetes, in part through the regulation of beta-cell mass in vivo. Studies in vitro have shown that the protein Ras homolog enriched in brain (Rheb) plays a key role as a positive upstream regulator of the mammalian target of rapamycin complex 1 (mTORC1) pathway in integrating inputs from nutrients and growth factors for cell growth. Our objective was to investigate the role of the mTORC1 pathway in the regulation of beta-cell mass in vivo. |
| Links |
PubMed PMC2682691 Online version:10.2337/db08-0519 |
| Keywords |
Animals; Cell Division; Diabetes Mellitus, Experimental/physiopathology; Diabetes Mellitus, Experimental/prevention & control; Glucagon-Secreting Cells/cytology; Glucagon-Secreting Cells/physiology; Glucose Tolerance Test; Humans; Hyperglycemia/prevention & control; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/physiology; Insulin-Secreting Cells/transplantation; Mice; Mice, Transgenic; Monomeric GTP-Binding Proteins/genetics; Neuropeptides/genetics; Proteins; Transcription Factors/genetics; Up-Regulation |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0032006: regulation of TOR signaling cascade |
ECO:0000315: |
P |
Fig 1 & Fig 5C show rapamycin suppresses the activity of mTORC1 |
complete | ||||
|
involved_in |
GO:0032006: regulation of TOR signaling |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:2000074: regulation of type B pancreatic cell development |
ECO:0000315: |
P |
Figure 3 shows increased beta cell mass in transgenic mice. |
complete | ||||
|
involved_in |
GO:2000074: regulation of type B pancreatic cell development |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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