HUMAN:RHEB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RHEB (synonyms: RHEB2)
Protein Name(s)	GTP-binding protein Rheb Ras homolog enriched in brain
External Links
UniProt	Q15382
EMBL	Z29677 D78132 AF148645 AF493921 AK125446 BT006958 AC005996 CH471173 BC016155 BC107705
CCDS	CCDS5927.1
PIR	S68419
RefSeq	NP_005605.1
UniGene	Hs.283521 Hs.568850 Hs.647068
PDB	1XTQ 1XTR 1XTS 3SEA 3T5G
PDBsum	1XTQ 1XTR 1XTS 3SEA 3T5G
DisProt	DP00364
ProteinModelPortal	Q15382
SMR	Q15382
BioGrid	111941
DIP	DIP-42816N
IntAct	Q15382
MINT	MINT-1365334
STRING	9606.ENSP00000262187
BindingDB	Q15382
ChEMBL	CHEMBL3108656
PhosphoSite	Q15382
DMDM	6919957
MaxQB	Q15382
PaxDb	Q15382
PRIDE	Q15382
DNASU	6009
Ensembl	ENST00000262187
GeneID	6009
KEGG	hsa:6009
UCSC	uc003wkh.1
CTD	6009
GeneCards	GC07M151163
HGNC	HGNC:10011
HPA	CAB019436 HPA054743
MIM	601293
neXtProt	NX_Q15382
PharmGKB	PA34389
eggNOG	COG1100
GeneTree	ENSGT00770000120482
HOGENOM	HOG000233973
HOVERGEN	HBG009351
InParanoid	Q15382
KO	K07208
OMA	TILNSKH
OrthoDB	EOG7Q2N6K
PhylomeDB	Q15382
TreeFam	TF314986
Reactome	REACT_21393 REACT_6754 REACT_6836 REACT_6838
SignaLink	Q15382
ChiTaRS	RHEB
EvolutionaryTrace	Q15382
GeneWiki	RHEB
GenomeRNAi	6009
NextBio	23445
PRO	PR:Q15382
Proteomes	UP000005640
Bgee	Q15382
CleanEx	HS_RHEB
ExpressionAtlas	Q15382
Genevestigator	Q15382
GO	GO:0005829 GO:0030425 GO:0070062 GO:0016020 GO:0043025 GO:0005886 GO:0005681 GO:0019003 GO:0005525 GO:0003924 GO:0046872 GO:0007050 GO:0008286 GO:0032008 GO:0007165 GO:0007264
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR020849
PANTHER	PTHR24070
Pfam	PF00071
PRINTS	PR00449
SMART	SM00173
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51421

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000074	regulation of type B pancreatic cell development	PMID:19258434^[1]	ECO:0000315			P		Figure 3 shows increased beta cell mass in transgenic mice.	complete CACAO 5929
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:28242620^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q921J2	P		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	PMID:15728574^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:15728574^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:15728574^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000074	regulation of type B pancreatic cell development	PMID:19258434^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	PMID:20381137^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q921J2	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:27898073^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:27898073^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:27898073^[7]	ECO:0001230	mass spectrometry evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:27898073^[7]	ECO:0001230	mass spectrometry evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q921J2 ensembl:ENSMUSP00000030787	P		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q921J2 ensembl:ENSMUSP00000030787	P		Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q921J2 ensembl:ENSMUSP00000030787	P		Seeded From UniProt	complete
involved_in	GO:0032006	regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q921J2 ensembl:ENSMUSP00000030787	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q921J2 ensembl:ENSMUSP00000030787	F		Seeded From UniProt	complete
part_of	GO:0005681	spliceosomal complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q921J2 ensembl:ENSMUSP00000030787	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q921J2 ensembl:ENSMUSP00000030787	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR037586	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR005225 InterPro:IPR020849	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	C		Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037586	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8206940^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8661031^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:8543055^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:8206940^[8] Reactome:R-HSA-5672017 Reactome:R-HSA-380979	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	Reactome:R-HSA-5675790 Reactome:R-HSA-5672817 Reactome:R-HSA-5672017 Reactome:R-HSA-5672010	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	Reactome:R-HSA-380972	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	Reactome:R-HSA-8944454 Reactome:R-HSA-5675790 Reactome:R-HSA-5673768 Reactome:R-HSA-5672843 Reactome:R-HSA-5672828 Reactome:R-HSA-5672824 Reactome:R-HSA-5672817 Reactome:R-HSA-5672017 Reactome:R-HSA-5672010 Reactome:R-HSA-447074 Reactome:R-HSA-380979 Reactome:R-HSA-377186 Reactome:R-HSA-165718 Reactome:R-HSA-165692 Reactome:R-HSA-165680 Reactome:R-HSA-165195	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hamada, S et al. (2009) Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia. Diabetes 58 1321-32 PubMed GONUTS page
↑ Meng, W et al. (2017) Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway. Diabetes 66 1198-1213 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Yu, Y et al. (2005) Structural basis for the unique biological function of small GTPase RHEB. J. Biol. Chem. 280 17093-100 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ Sancak, Y et al. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141 290-303 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Föcking, M et al. (2016) Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder. Transl Psychiatry 6 e959 PubMed GONUTS page
↑ ^8.0 ^8.1 Yamagata, K et al. (1994) rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J. Biol. Chem. 269 16333-9 PubMed GONUTS page
↑ Mizuki, N et al. (1996) Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36. Genomics 34 114-8 PubMed GONUTS page
↑ Gromov, PS et al. (1995) A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb. FEBS Lett. 377 221-6 PubMed GONUTS page

[PMID:19258434-1] 1.0 ^1.1 Hamada, S et al. (2009) Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia. Diabetes 58 1321-32 PubMed GONUTS page

[PMID:28242620-2] Meng, W et al. (2017) Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway. Diabetes 66 1198-1213 PubMed GONUTS page

[PMID:15728574-3] 3.0 ^3.1 ^3.2 Yu, Y et al. (2005) Structural basis for the unique biological function of small GTPase RHEB. J. Biol. Chem. 280 17093-100 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-5] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:20381137-6] Sancak, Y et al. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141 290-303 PubMed GONUTS page

[PMID:27898073-7] 7.0 ^7.1 ^7.2 ^7.3 Föcking, M et al. (2016) Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder. Transl Psychiatry 6 e959 PubMed GONUTS page

[PMID:8206940-8] 8.0 ^8.1 Yamagata, K et al. (1994) rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J. Biol. Chem. 269 16333-9 PubMed GONUTS page

[PMID:8661031-9] Mizuki, N et al. (1996) Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36. Genomics 34 114-8 PubMed GONUTS page

[PMID:8543055-10] Gromov, PS et al. (1995) A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb. FEBS Lett. 377 221-6 PubMed GONUTS page

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HUMAN:RHEB

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