MOUSE:RHEB

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rheb
Protein Name(s)	GTP-binding protein Rheb Ras homolog enriched in brain
External Links
UniProt	Q921J2
EMBL	BC012273
CCDS	CCDS39032.1
RefSeq	NP_444305.2
UniGene	Mm.319175
PDB	4O25 4O2L 4O2R
PDBsum	4O25 4O2L 4O2R
ProteinModelPortal	Q921J2
SMR	Q921J2
BioGrid	202889
IntAct	Q921J2
MINT	MINT-4611176
PhosphoSite	Q921J2
MaxQB	Q921J2
PaxDb	Q921J2
PRIDE	Q921J2
Ensembl	ENSMUST00000030787
GeneID	19744
KEGG	mmu:19744
UCSC	uc008wsj.1
CTD	6009
MGI	MGI:97912
eggNOG	COG1100
GeneTree	ENSGT00770000120482
HOGENOM	HOG000233973
HOVERGEN	HBG009351
InParanoid	Q921J2
KO	K07208
OMA	TILNSKH
OrthoDB	EOG7Q2N6K
PhylomeDB	Q921J2
TreeFam	TF314986
Reactome	REACT_241655 REACT_255725 REACT_257725 REACT_260675
ChiTaRS	Rheb
NextBio	297194
PRO	PR:Q921J2
Proteomes	UP000000589
Bgee	Q921J2
CleanEx	MM_RHEB
ExpressionAtlas	Q921J2
Genevestigator	Q921J2
GO	GO:0030425 GO:0070062 GO:0043025 GO:0005886 GO:0005681 GO:0019003 GO:0005525 GO:0046872 GO:0019901 GO:0006184 GO:0032008 GO:0007264
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR020849
PANTHER	PTHR24070
Pfam	PF00071
PRINTS	PR00449
SMART	SM00173
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51421

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032006	regulation of TOR signaling cascade	PMID:19258434^[1]	ECO:0000315			P		Fig 1 & Fig 5C show rapamycin suppresses the activity of mTORC1	complete CACAO 5974
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:28242620^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032006	regulation of TOR signaling	PMID:19258434^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	PMID:21336308^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21336308^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O54992	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:21336308^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000074	regulation of type B pancreatic cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15382	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099175	regulation of postsynapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621840	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621840	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048714	positive regulation of oligodendrocyte differentiation	PMID:25411504^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179311,MGI:MGI:3850507	P	regulates_o_occurs_in:(EMAPA:16894) occurs_in:(CL:0002453)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621840	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032008	positive regulation of TOR signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15382	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621840	C		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15382	F		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621840	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15382	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621840	P		Seeded From UniProt	complete
part_of	GO:0005681	spliceosomal complex	PMID:11555636^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15382	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621840	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621840	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15382	F		Seeded From UniProt	complete
involved_in	GO:2000074	regulation of type B pancreatic cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15382 ensembl:ENSP00000262187	P		Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15382 ensembl:ENSP00000262187	P		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15382 ensembl:ENSP00000262187	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15382 ensembl:ENSP00000262187	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15382 ensembl:ENSP00000262187	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15382 ensembl:ENSP00000262187	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR037586	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR005225 InterPro:IPR020849	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	C		Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037586	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hamada, S et al. (2009) Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia. Diabetes 58 1321-32 PubMed GONUTS page
↑ Meng, W et al. (2017) Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway. Diabetes 66 1198-1213 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Zheng, M et al. (2011) Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat. Cell Biol. 13 263-72 PubMed GONUTS page
↑ Zou, Y et al. (2014) Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. J. Neurosci. 34 15764-78 PubMed GONUTS page
↑ Sutherland, HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum. Mol. Genet. 10 1995-2011 PubMed GONUTS page

[PMID:19258434-1] 1.0 ^1.1 Hamada, S et al. (2009) Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia. Diabetes 58 1321-32 PubMed GONUTS page

[PMID:28242620-2] Meng, W et al. (2017) Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway. Diabetes 66 1198-1213 PubMed GONUTS page

[PMID:21336308-3] 3.0 ^3.1 ^3.2 Zheng, M et al. (2011) Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat. Cell Biol. 13 263-72 PubMed GONUTS page

[PMID:25411504-4] Zou, Y et al. (2014) Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. J. Neurosci. 34 15764-78 PubMed GONUTS page

[PMID:11555636-5] Sutherland, HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum. Mol. Genet. 10 1995-2011 PubMed GONUTS page

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MOUSE:RHEB

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