PMID:17292801

Citation	Krzeminski, P, Misiewicz, I, Pomorski, P, Kasprzycka-Guttman, T, Barańska, J and Brańska, J (2007) Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells. Brain Res. Bull. 71:587-92
Abstract	We have previously shown that P2Y1, P2Y2 and P2Y12 nucleotide receptors are functionally expressed and active on the cell surface of rat glioma C6 cells. In the present study, we have immunocytochemically shown their sub-cellular colocalization with mitochondria in these cells. The same colocalization of above receptors has been found in rat astrocytes. Additionally, differences in intracellular distribution of examined receptors between both cell lines have been observed. This data indicates that P2Y1, P2Y2 and P2Y12 receptor proteins exist within mitochondria of astrocytes and C6 cells, although their role in these sub-cellular structures remains unclear.
Links	PubMed Online version:10.1016/j.brainresbull.2006.11.013
Keywords	Animals; Astrocytes/metabolism; Astrocytes/ultrastructure; Brain Neoplasms/metabolism; Cell Line, Tumor; Central Nervous System/cytology; Central Nervous System/metabolism; Glioma/metabolism; Immunohistochemistry; Membrane Proteins/metabolism; Mitochondria/metabolism; Mitochondria/ultrastructure; Rats; Receptors, Purinergic/metabolism; Receptors, Purinergic P2/metabolism; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:P2RY1	colocalizes_with	GO:0005739: mitochondrion	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
RAT:P2RY2	colocalizes_with	GO:0005739: mitochondrion	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete

References

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