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RAT:P2RY2

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) P2ry2 (synonyms: P2ru1)
Protein Name(s) P2Y purinoceptor 2

P2Y2 ATP receptor P2U purinoceptor 1 P2U1 Purinergic receptor

External Links
UniProt P41232
EMBL U09402
L46865
U56839
BC061754
RefSeq NP_058951.1
UniGene Rn.11102
ProteinModelPortal P41232
STRING 10116.ENSRNOP00000026115
BindingDB P41232
ChEMBL CHEMBL4419
GuidetoPHARMACOLOGY 324
PhosphoSite P41232
PRIDE P41232
GeneID 29597
KEGG rno:29597
UCSC RGD:62088
CTD 5029
RGD 62088
eggNOG NOG147537
HOGENOM HOG000231307
HOVERGEN HBG101120
InParanoid P41232
KO K04269
PhylomeDB P41232
NextBio 609746
PRO PR:P41232
Proteomes UP000002494
Genevestigator P41232
GO GO:0016324
GO:0016323
GO:0016021
GO:0031686
GO:0005524
GO:0045028
GO:0045030
GO:0007568
GO:0071347
GO:0071222
GO:0071415
GO:0035589
GO:0001701
GO:0030279
GO:0007200
GO:0032722
GO:0007204
GO:0070257
GO:0010976
GO:0060406
GO:0032308
GO:0014911
GO:0042312
GO:0070848
GO:0019233
GO:0042060
InterPro IPR000276
IPR017452
IPR000356
PANTHER PTHR24231:SF17
Pfam PF00001
PRINTS PR00237
PR00594
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

NOT|involved_in

GO:0001774

microglial cell activation

PMID:11245682[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031686

A1 adenosine receptor binding

PMID:11390975[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P25099

F

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:16000618[3]

ECO:0006062

wide-field fluorescence microscopy evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:16000618[3]

ECO:0006054

pharmacological assay evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:16000618[3]

ECO:0006042

cell fractionation evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:16000618[3]

ECO:0000279

western blot evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0099509

regulation of presynaptic cytosolic calcium ion concentration

PMID:16000618[3]

ECO:0006062

wide-field fluorescence microscopy evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0099509

regulation of presynaptic cytosolic calcium ion concentration

PMID:16000618[3]

ECO:0006054

pharmacological assay evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0099509

regulation of presynaptic cytosolic calcium ion concentration

PMID:16000618[3]

ECO:0006042

cell fractionation evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0099509

regulation of presynaptic cytosolic calcium ion concentration

PMID:16000618[3]

ECO:0000279

western blot evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0099059

integral component of presynaptic active zone membrane

PMID:16000618[3]

ECO:0006042

cell fractionation evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0099059

integral component of presynaptic active zone membrane

PMID:16000618[3]

ECO:0000279

western blot evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:16000618[3]

ECO:0006062

wide-field fluorescence microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:16000618[3]

ECO:0006054

pharmacological assay evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:16000618[3]

ECO:0006042

cell fractionation evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:16000618[3]

ECO:0000279

western blot evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0097746

regulation of blood vessel diameter

PMID:12730558[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071415

cellular response to purine-containing compound

PMID:16831297[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071347

cellular response to interleukin-1

PMID:19317852[6]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:18689605[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070848

response to growth factor

PMID:14714568[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060406

positive regulation of penile erection

PMID:19303093[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0045030

UTP-activated nucleotide receptor activity

PMID:15924261[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

PMID:14714568[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032722

positive regulation of chemokine production

PMID:17947675[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032308

positive regulation of prostaglandin secretion

PMID:15840771[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030279

negative regulation of ossification

PMID:12210747[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019233

sensory perception of pain

PMID:15740803[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:11557527[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

PMID:11557527[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0014911

positive regulation of smooth muscle cell migration

PMID:11934835[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010976

positive regulation of neuron projection development

PMID:15379893[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

PMID:11738148[18]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:19155635[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0005769

early endosome

PMID:15924261[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0005764

lysosome

PMID:15924261[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0005739

mitochondrion

PMID:17292801[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:11557527[15]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001701

in utero embryonic development

PMID:14517997[21]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035589

G protein-coupled purinergic nucleotide receptor signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0045028

P

Seeded From UniProt

complete

involved_in

GO:0035589

G protein-coupled purinergic nucleotide receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0045028

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

P

Seeded From UniProt

complete

involved_in

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000356

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000356
InterPro:IPR017452

C

Seeded From UniProt

complete

enables

GO:0045028

G protein-coupled purinergic nucleotide receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000356

F

Seeded From UniProt

complete

involved_in

GO:0070257

positive regulation of mucus secretion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000356

P

Seeded From UniProt

complete

involved_in

GO:0097746

regulation of blood vessel diameter

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000356

P

Seeded From UniProt

complete

enables

GO:0045028

G protein-coupled purinergic nucleotide receptor activity

PMID:9437211[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Honda, S et al. (2001) Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 21 1975-82 PubMed GONUTS page
  2. Yoshioka, K et al. (2001) Heteromeric association creates a P2Y-like adenosine receptor. Proc. Natl. Acad. Sci. U.S.A. 98 7617-22 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 Rodrigues, RJ et al. (2005) Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. J. Neurosci. 25 6286-95 PubMed GONUTS page
  4. Horiuchi, T et al. (2003) Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles. Stroke 34 1473-8 PubMed GONUTS page
  5. Ballerini, P et al. () P2Y2 receptor up-regulation induced by guanosine or UTP in rat brain cultured astrocytes. Int J Immunopathol Pharmacol 19 293-308 PubMed GONUTS page
  6. Kong, Q et al. (2009) Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor. J. Neurochem. 109 1300-10 PubMed GONUTS page
  7. Garcia-Verdugo, I et al. (2008) Long-term exposure to LPS enhances the rate of stimulated exocytosis and surfactant secretion in alveolar type II cells and upregulates P2Y2 receptor expression. Am. J. Physiol. Lung Cell Mol. Physiol. 295 L708-17 PubMed GONUTS page
  8. 8.0 8.1 Greig, AV et al. (2003) Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing. Exp. Dermatol. 12 860-71 PubMed GONUTS page
  9. Gur, S et al. (2009) Management of erectile function by penile purinergic p2 receptors in the diabetic rat. J. Urol. 181 2375-82 PubMed GONUTS page
  10. 10.0 10.1 10.2 Tulapurkar, ME et al. (2005) Endocytosis mechanism of P2Y2 nucleotide receptor tagged with green fluorescent protein: clathrin and actin cytoskeleton dependence. Cell. Mol. Life Sci. 62 1388-99 PubMed GONUTS page
  11. Stokes, L & Surprenant, A (2007) Purinergic P2Y2 receptors induce increased MCP-1/CCL2 synthesis and release from rat alveolar and peritoneal macrophages. J. Immunol. 179 6016-23 PubMed GONUTS page
  12. Sun, R et al. (2005) P2Y2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Am. J. Physiol. Renal Physiol. 289 F585-92 PubMed GONUTS page
  13. Hoebertz, A et al. (2002) ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling. J. Cell. Biochem. 86 413-9 PubMed GONUTS page
  14. Yajima, H et al. (2005) Inhibitory, facilitatory, and excitatory effects of ATP and purinergic receptor agonists on the activity of rat cutaneous nociceptors in vitro. Neurosci. Res. 51 405-16 PubMed GONUTS page
  15. 15.0 15.1 15.2 Dranoff, JA et al. (2001) Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Am. J. Physiol. Gastrointest. Liver Physiol. 281 G1059-67 PubMed GONUTS page
  16. Pillois, X et al. (2002) Nucleotide receptors involved in UTP-induced rat arterial smooth muscle cell migration. Circ. Res. 90 678-81 PubMed GONUTS page
  17. Chorna, NE et al. (2004) P2Y receptors activate neuroprotective mechanisms in astrocytic cells. J. Neurochem. 91 119-32 PubMed GONUTS page
  18. Miao, LY et al. (2001) Age-related changes in P2 receptor mRNA of rat cerebral arteries. Exp. Gerontol. 37 67-79 PubMed GONUTS page
  19. Agca, C et al. (2009) Development of a novel transgenic rat overexpressing the P2Y(2) nucleotide receptor using a lentiviral vector. J. Vasc. Res. 46 447-58 PubMed GONUTS page
  20. Krzeminski, P et al. (2007) Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells. Brain Res. Bull. 71 587-92 PubMed GONUTS page
  21. Cheung, KK et al. (2003) Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development. Dev. Dyn. 228 254-66 PubMed GONUTS page
  22. Seye, CI et al. (1997) Overexpression of P2Y2 purinoceptor in intimal lesions of the rat aorta. Arterioscler. Thromb. Vasc. Biol. 17 3602-10 PubMed GONUTS page