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RAT:P2RY2
Contents
Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
Gene Name(s) | P2ry2 (synonyms: P2ru1) | |
Protein Name(s) | P2Y purinoceptor 2
P2Y2 ATP receptor P2U purinoceptor 1 P2U1 Purinergic receptor | |
External Links | ||
UniProt | P41232 | |
EMBL | U09402 L46865 U56839 BC061754 | |
RefSeq | NP_058951.1 | |
UniGene | Rn.11102 | |
ProteinModelPortal | P41232 | |
STRING | 10116.ENSRNOP00000026115 | |
BindingDB | P41232 | |
ChEMBL | CHEMBL4419 | |
GuidetoPHARMACOLOGY | 324 | |
PhosphoSite | P41232 | |
PRIDE | P41232 | |
GeneID | 29597 | |
KEGG | rno:29597 | |
UCSC | RGD:62088 | |
CTD | 5029 | |
RGD | 62088 | |
eggNOG | NOG147537 | |
HOGENOM | HOG000231307 | |
HOVERGEN | HBG101120 | |
InParanoid | P41232 | |
KO | K04269 | |
PhylomeDB | P41232 | |
NextBio | 609746 | |
PRO | PR:P41232 | |
Proteomes | UP000002494 | |
Genevestigator | P41232 | |
GO | GO:0016324 GO:0016323 GO:0016021 GO:0031686 GO:0005524 GO:0045028 GO:0045030 GO:0007568 GO:0071347 GO:0071222 GO:0071415 GO:0035589 GO:0001701 GO:0030279 GO:0007200 GO:0032722 GO:0007204 GO:0070257 GO:0010976 GO:0060406 GO:0032308 GO:0014911 GO:0042312 GO:0070848 GO:0019233 GO:0042060 | |
InterPro | IPR000276 IPR017452 IPR000356 | |
PANTHER | PTHR24231:SF17 | |
Pfam | PF00001 | |
PRINTS | PR00237 PR00594 | |
PROSITE | PS00237 PS50262 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
NOT|involved_in |
GO:0001774 |
microglial cell activation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0031686 |
A1 adenosine receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0006062 |
wide-field fluorescence microscopy evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0006054 |
pharmacological assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0000279 |
western blot evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0006062 |
wide-field fluorescence microscopy evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0006054 |
pharmacological assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0000279 |
western blot evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0099059 |
integral component of presynaptic active zone membrane |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
part_of |
GO:0099059 |
integral component of presynaptic active zone membrane |
ECO:0000279 |
western blot evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0006062 |
wide-field fluorescence microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0006054 |
pharmacological assay evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0006042 |
cell fractionation evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000279 |
western blot evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097746 |
regulation of blood vessel diameter |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071415 |
cellular response to purine-containing compound |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071347 |
cellular response to interleukin-1 |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070848 |
response to growth factor |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060406 |
positive regulation of penile erection |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0045030 |
UTP-activated nucleotide receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042060 |
wound healing |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032722 |
positive regulation of chemokine production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032308 |
positive regulation of prostaglandin secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030279 |
negative regulation of ossification |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019233 |
sensory perception of pain |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0014911 |
positive regulation of smooth muscle cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007568 |
aging |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005769 |
early endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005764 |
lysosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001701 |
in utero embryonic development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035589 |
G protein-coupled purinergic nucleotide receptor signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0045028 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035589 |
G protein-coupled purinergic nucleotide receptor signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0045028 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007200 |
phospholipase C-activating G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0045028 |
G protein-coupled purinergic nucleotide receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070257 |
positive regulation of mucus secretion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097746 |
regulation of blood vessel diameter |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0045028 |
G protein-coupled purinergic nucleotide receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Honda, S et al. (2001) Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 21 1975-82 PubMed GONUTS page
- ↑ Yoshioka, K et al. (2001) Heteromeric association creates a P2Y-like adenosine receptor. Proc. Natl. Acad. Sci. U.S.A. 98 7617-22 PubMed GONUTS page
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 Rodrigues, RJ et al. (2005) Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. J. Neurosci. 25 6286-95 PubMed GONUTS page
- ↑ Horiuchi, T et al. (2003) Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles. Stroke 34 1473-8 PubMed GONUTS page
- ↑ Ballerini, P et al. () P2Y2 receptor up-regulation induced by guanosine or UTP in rat brain cultured astrocytes. Int J Immunopathol Pharmacol 19 293-308 PubMed GONUTS page
- ↑ Kong, Q et al. (2009) Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor. J. Neurochem. 109 1300-10 PubMed GONUTS page
- ↑ Garcia-Verdugo, I et al. (2008) Long-term exposure to LPS enhances the rate of stimulated exocytosis and surfactant secretion in alveolar type II cells and upregulates P2Y2 receptor expression. Am. J. Physiol. Lung Cell Mol. Physiol. 295 L708-17 PubMed GONUTS page
- ↑ 8.0 8.1 Greig, AV et al. (2003) Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing. Exp. Dermatol. 12 860-71 PubMed GONUTS page
- ↑ Gur, S et al. (2009) Management of erectile function by penile purinergic p2 receptors in the diabetic rat. J. Urol. 181 2375-82 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Tulapurkar, ME et al. (2005) Endocytosis mechanism of P2Y2 nucleotide receptor tagged with green fluorescent protein: clathrin and actin cytoskeleton dependence. Cell. Mol. Life Sci. 62 1388-99 PubMed GONUTS page
- ↑ Stokes, L & Surprenant, A (2007) Purinergic P2Y2 receptors induce increased MCP-1/CCL2 synthesis and release from rat alveolar and peritoneal macrophages. J. Immunol. 179 6016-23 PubMed GONUTS page
- ↑ Sun, R et al. (2005) P2Y2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Am. J. Physiol. Renal Physiol. 289 F585-92 PubMed GONUTS page
- ↑ Hoebertz, A et al. (2002) ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling. J. Cell. Biochem. 86 413-9 PubMed GONUTS page
- ↑ Yajima, H et al. (2005) Inhibitory, facilitatory, and excitatory effects of ATP and purinergic receptor agonists on the activity of rat cutaneous nociceptors in vitro. Neurosci. Res. 51 405-16 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Dranoff, JA et al. (2001) Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Am. J. Physiol. Gastrointest. Liver Physiol. 281 G1059-67 PubMed GONUTS page
- ↑ Pillois, X et al. (2002) Nucleotide receptors involved in UTP-induced rat arterial smooth muscle cell migration. Circ. Res. 90 678-81 PubMed GONUTS page
- ↑ Chorna, NE et al. (2004) P2Y receptors activate neuroprotective mechanisms in astrocytic cells. J. Neurochem. 91 119-32 PubMed GONUTS page
- ↑ Miao, LY et al. (2001) Age-related changes in P2 receptor mRNA of rat cerebral arteries. Exp. Gerontol. 37 67-79 PubMed GONUTS page
- ↑ Agca, C et al. (2009) Development of a novel transgenic rat overexpressing the P2Y(2) nucleotide receptor using a lentiviral vector. J. Vasc. Res. 46 447-58 PubMed GONUTS page
- ↑ Krzeminski, P et al. (2007) Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells. Brain Res. Bull. 71 587-92 PubMed GONUTS page
- ↑ Cheung, KK et al. (2003) Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development. Dev. Dyn. 228 254-66 PubMed GONUTS page
- ↑ Seye, CI et al. (1997) Overexpression of P2Y2 purinoceptor in intimal lesions of the rat aorta. Arterioscler. Thromb. Vasc. Biol. 17 3602-10 PubMed GONUTS page
a
c
g
- Glires
- GO:0098978 ! glutamatergic synapse
- GO:0007186 ! G protein-coupled receptor signaling pathway
- GO:0004930 ! G protein-coupled receptor activity
- GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity
- GO:0045030 ! G protein-coupled UTP receptor activity
- GO:0035589 ! G protein-coupled purinergic nucleotide receptor signaling pathway
m
o
p
- GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0005886 ! plasma membrane
- GO:0010976 ! positive regulation of neuron projection development
- GO:0014911 ! positive regulation of smooth muscle cell migration
- GO:0070257 ! positive regulation of mucus secretion
- GO:0032308 ! positive regulation of prostaglandin secretion
- GO:0032722 ! positive regulation of chemokine production
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0060406 ! positive regulation of penile erection
r