PMID:16020269

Citation	Gordon, YJ, Huang, LC, Romanowski, EG, Yates, KA, Proske, RJ and McDermott, AM (2005) Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity. Curr. Eye Res. 30:385-94
Abstract	This study determined whether LL-37 (cathelicidin) is expressed by conjunctival and corneal epithelia as part of ocular host defense. The antimicrobial activity of LL-37 was also assessed in vitro against Pseudomonas aeruginosa (PA), Staphylococcus aureus (SA), Staphylococcus epidermidis (SE), herpes simplex virus type 1 (HSV-1), and adenovirus (Ad).
Links	PubMed PMC1497871 Online version:10.1080/02713680590934111
Keywords	Adenoviridae/drug effects; Anti-Bacterial Agents/pharmacology; Antimicrobial Cationic Peptides/genetics; Antimicrobial Cationic Peptides/pharmacology; Antiviral Agents/pharmacology; Cell Culture Techniques; Conjunctiva/cytology; Conjunctiva/metabolism; Epithelial Cells/metabolism; Epithelium, Corneal/metabolism; Gene Expression; Herpesvirus 1, Human/drug effects; Humans; Immunoblotting; Pseudomonas aeruginosa/drug effects; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcus aureus/drug effects; Staphylococcus epidermidis/drug effects
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:CAMP		GO:0042742: defense response to bacterium	ECO:0000314:		P		The human cathelicidin antimicrobial peptide can be cleaved into two peptides, one of which being the antibacterial peptide LL-37. The antibacterial activity of LL-37 against Pseudomonas Aeruginosa, Staphylococcus Aureus, and Staphylococcus Epidermidis was tested using an antibacterial assay. The results showed that at 100 μg/ml, LL-37 was completely bactericidal for all strains of PA, as shown in Figure 2. LL-37 also showed potent bactericidal activity against SA and SE with EC50 values being 1.6 ± 1.5 (n = 3) and 1.31.9 (n 3) μg/ml, respectively.	complete CACAO 12385
HUMAN:CAMP		GO:0051873: killing by host of symbiont cells	ECO:0000314:		P		Human cathelicidin antimicrobial peptide has the ability to kill the cells of other organisms. It can be cleaved into two peptides, one of which being the antibacterial peptide LL-37. The antibacterial activity of LL-37 against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis was tested using an antibacterial assay. The results showed that at 100 μg/ml, LL-37 was completely bactericidal for all strains of Pseudomonas aeruginosa (Figure 2). LL-37 also showed potent bactericidal activity against Staphylococcus aureus and Staphylococcus epidermidis with EC50 values being 1.6 ± 1.5 (n = 3) and 1.31.9 (n 3) μg/ml, respectively (Figure 2).	complete CACAO 12515
HUMAN:CAMP		GO:0002376: immune system process	ECO:0000314:		P		Human cathelicidin antimicrobial peptide plays a role in immune system processes. It can be cleaved into two peptides, one of which being the antibacterial peptide LL-37. The antibacterial immune activity of LL-37 against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis was tested using an antibacterial assay. The results showed that at 100 μg/ml, LL-37 was completely bactericidal for all strains of Pseudomonas aeruginosa (Figure 2). LL-37 also showed potent bactericidal activity against Staphylococcus aureus and Staphylococcus epidermidis with EC50 values being 1.6 ± 1.5 (n = 3) and 1.31.9 (n 3) μg/ml, respectively (Figure 2).	complete CACAO 12516
HUMAN:CAMP		GO:0016045: detection of bacterium	ECO:0000314:		P		Human cathelicidin antimicrobial peptide has the ability to detect bacterial cells and express antibacterial activity against them. It can be cleaved into two peptides, one of which being the antibacterial peptide LL-37. The antibacterial activity of LL-37 against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis was tested using an antibacterial assay. The results showed that at 100 μg/ml, LL-37 was completely bactericidal for all strains of Pseudomonas aeruginosa (Figure 2). LL-37 also showed potent bactericidal activity against Staphylococcus aureus and Staphylococcus epidermidis with EC50 values being 1.6 ± 1.5 (n = 3) and 1.31.9 (n 3) μg/ml, respectively (Figure 2).	complete CACAO 12517

References

See Help:References for how to manage references in GONUTS.