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NEUCR:SYV
Contents
| Species (Taxon ID) | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM1257 / FGSC 987). (367110) | |
| Gene Name(s) | cyt-20 (synonyms: un-3) | |
| Protein Name(s) | Valine--tRNA ligase, mitochondrial
Valyl-tRNA synthetase ValRS | |
| External Links | ||
| UniProt | P28350 | |
| EMBL | M64703 CM002236 | |
| PIR | A41251 | |
| RefSeq | XP_964329.2 | |
| UniGene | Ncr.15346 | |
| ProteinModelPortal | P28350 | |
| STRING | 5141.NCU01965.1 | |
| EnsemblFungi | [example_ID EFNCRT00000001058] | |
| GeneID | 3880494 | |
| KEGG | ncr:NCU01965 | |
| eggNOG | COG0525 | |
| HOGENOM | HOG000020094 | |
| InParanoid | P28350 | |
| KO | K01873 | |
| OrthoDB | EOG7H1JTZ | |
| Proteomes | UP000001805 | |
| GO | GO:0005739 GO:0002161 GO:0005524 GO:0004832 GO:0006438 | |
| Gene3D | 1.10.730.10 3.40.50.620 3.90.740.10 | |
| HAMAP | MF_02004 | |
| InterPro | IPR001412 IPR002300 IPR013155 IPR014729 IPR009080 IPR009008 IPR002303 | |
| PANTHER | PTHR11946:SF5 | |
| Pfam | PF08264 PF00133 | |
| PRINTS | PR00986 | |
| SUPFAM | SSF47323 SSF50677 | |
| TIGRFAMs | TIGR00422 | |
| PROSITE | PS00178 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005739 |
mitochondrion |
ECO:0000315 |
C |
Figure 4 shows compromised mitochondrial protein synthesis in vars mutant |
complete | |||||
| GO:0005739 |
mitochondrion |
ECO:0000315 |
C |
Figure 6 shows altered steady-state levels of mutant VARS proteins. |
complete | |||||
| GO:0004832 |
valine-tRNA ligase activity |
ECO:0000314 |
F |
Figure 4 shows decreased protein synthesis in vars mutant. |
complete | |||||
| GO:0004832 |
valine-tRNA ligase activity |
ECO:0000314 |
F |
Figure 6 shows altered mitochondrial proteins in vars mutants. |
complete | |||||
| GO:0004812 |
aminoacyl-tRNA ligase activity |
ECO:0000314 |
F |
Figure 5 shows altered cytochrome content due to vars mutation. |
complete | |||||
| GO:0004743 |
pyruvate kinase activity |
ECO:0000314 |
F |
Table 1 shows increased pyruvate kinase activity in Cn1 pre- and post-treated diabetic test subjects. |
complete | |||||
|
involved_in |
GO:0006438 |
valyl-tRNA aminoacylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11067 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11067 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004832 |
valine-tRNA ligase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11067 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0106074 |
aminoacyl-tRNA metabolism involved in translational fidelity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0002161 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75005 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004832 |
valine-tRNA ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75005 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001412 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002161 |
aminoacyl-tRNA editing activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004812 |
aminoacyl-tRNA ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001412 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004832 |
valine-tRNA ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001412 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006418 |
tRNA aminoacylation for protein translation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001412 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006438 |
valyl-tRNA aminoacylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004832 |
valine-tRNA ligase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004812 |
aminoacyl-tRNA ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006412 |
translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Duarte, M & Videira, A (2012) Defective valyl-tRNA synthetase hampers the mitochondrial respiratory chain in Neurospora crassa. Biochem. J. 448 297-306 PubMed GONUTS page
- ↑ Renjith, RS & Rajamohan, T () Protective and curative effects of Cocos nucifera inflorescence on alloxan-induced pancreatic cytotoxicity in rats. Indian J Pharmacol 44 555-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
