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MYCTU:O53896
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | pepD (ECO:0000313 with EMBL:CCP43733.1) | |
| Protein Name(s) | Peptidase S1 (ECO:0000313 with EMBL:AIR13718.1)
Probable serine protease PepD (Serine proteinase) (MTB32B) (ECO:0000313 with EMBL:CCP43733.1) Serine protease PepD (ECO:0000313 with EMBL:AFN48872.1) | |
| External Links | ||
| UniProt | O53896 | |
| EMBL | CP003248 CP009480 AL123456 JLDD01000011 | |
| RefSeq | NP_215498.1 YP_006514343.1 | |
| PDB | 1Y8T 2Z9I | |
| PDBsum | 1Y8T 2Z9I | |
| SMR | O53896 | |
| STRING | 83332.Rv0983 | |
| MEROPS | S01.494 | |
| PRIDE | O53896 | |
| EnsemblBacteria | AFN48872 CCP43733 | |
| GeneID | 13319543 885382 | |
| KEGG | mtu:Rv0983 mtv:RVBD_0983 | |
| PATRIC | 18150710 | |
| KO | K08372 | |
| OMA | TINDPRE | |
| OrthoDB | EOG6XQ3NR | |
| PhylomeDB | O53896 | |
| BioCyc | MTBRV:RV0983-MONOMER | |
| Proteomes | UP000001584 UP000003123 | |
| GO | GO:0005576 GO:0004252 GO:0008236 GO:0009405 GO:0030163 GO:0006508 GO:0006950 | |
| Gene3D | 2.30.42.10 | |
| InterPro | IPR001478 IPR001940 IPR009003 | |
| Pfam | PF13180 | |
| PRINTS | PR00834 | |
| SMART | SM00228 | |
| SUPFAM | SSF50156 SSF50494 | |
| PROSITE | PS50106 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006508 |
proteolysis |
ECO:0000314 |
P |
Proteins that interact with PepD were selected by co-immunoprecipitation carried out with with M. smegmatis ΔpepD (Figure 2C). These were then identified using LC MS/MS, and co-immunoprecipitation and LC MS/MS were repeated with M. tuberculosis Δpep, indicating several proteins which interact with PepD (Tables S3-7).The 35-kDa antigen was the top scoring protein for probable interaction with PepD(Table 1). Specifically with the 35-kDa antigenFigure 3D shows the presence of a lower molecular weight protein that is immunoreactive with the anti-FLAG monoclonal antibody in the wild-type M. tuberculosis pepD strain. This indicates that PepD interacts with/ cleaves the 35-kDa antigen |
complete | |||||
|
involved_in |
GO:0030163 |
protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071236 |
cellular response to antibiotic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ White, MJ et al. (2011) The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein. PLoS ONE 6 e18175 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Mohamedmohaideen, NN et al. (2008) Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis. Biochemistry 47 6092-102 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 White, MJ et al. (2010) PepD participates in the mycobacterial stress response mediated through MprAB and SigE. J. Bacteriol. 192 1498-510 PubMed GONUTS page
- ↑ McCann, JR et al. (2011) Genome-wide identification of Mycobacterium tuberculosis exported proteins with roles in intracellular growth. J. Bacteriol. 193 854-61 PubMed GONUTS page
- ↑ Skeiky, YA et al. (1999) Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis. Infect. Immun. 67 3998-4007 PubMed GONUTS page
