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MYCTU:O53166
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | acn (ECO:0000313 with EMBL:CCP44235.1) | |
| Protein Name(s) | Iron-regulated aconitate hydratase Can (ECO:0000313 with EMBL:AFN49388.1)
Probable iron-regulated aconitate hydratase Acn (Citrate hydro-lyase) (Aconitase) (ECO:0000313 with EMBL:CCP44235.1) | |
| External Links | ||
| UniProt | O53166 | |
| EMBL | CP003248 AL123456 JLDD01000018 | |
| RefSeq | NP_215991.1 YP_006514859.1 | |
| ProteinModelPortal | O53166 | |
| SMR | O53166 | |
| STRING | 83332.Rv1475c | |
| EnsemblBacteria | AFN49388 CCP44235 KBJ34833 | |
| GeneID | 13320068 886545 | |
| KEGG | mtu:Rv1475c mtv:RVBD_1475c | |
| PATRIC | 18125112 | |
| TubercuList | Rv1475c | |
| KO | K01681 | |
| OMA | EHVENLA | |
| OrthoDB | EOG67DPHM | |
| PhylomeDB | O53166 | |
| BioCyc | MetaCyc:MONOMER-11945 | |
| Proteomes | UP000001584 UP000003123 | |
| GO | GO:0005618 GO:0005829 GO:0005576 GO:0005886 GO:0003994 GO:0030350 GO:0040007 GO:0010039 | |
| Gene3D | 3.20.19.10 3.30.499.10 3.40.1060.10 | |
| InterPro | IPR015931 IPR015937 IPR001030 IPR015928 IPR015934 IPR015932 IPR018136 IPR000573 | |
| PANTHER | PTHR11670 PTHR11670:SF1 | |
| Pfam | PF00330 PF00694 | |
| PRINTS | PR00415 | |
| SUPFAM | SSF52016 SSF53732 | |
| PROSITE | PS00450 PS01244 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0003994 |
aconitate hydratase activity |
ECO:0000314 |
F |
purified protein with assay |
complete | |||||
| GO:0005506 |
iron ion binding |
ECO:0000314 |
F |
Source: UniProtKB-KW; Purified the protein and showed that the activity of the protein was lost in the presences of an iron chelator. |
complete | |||||
|
enables |
GO:0003730 |
mRNA 3'-UTR binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047456 |
2-methylisocitrate dehydratase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030350 |
iron-responsive element binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010039 |
response to iron ion |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003994 |
aconitate hydratase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11325 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006101 |
citrate metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000186700 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000186700 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11325 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003994 |
aconitate hydratase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11325 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003994 |
aconitate hydratase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047456 |
2-methylisocitrate dehydratase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019679 |
propionate metabolic process, methylcitrate cycle |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051536 |
iron-sulfur cluster binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0816 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Banerjee, S et al. (2007) Iron-dependent RNA-binding activity of Mycobacterium tuberculosis aconitase. J. Bacteriol. 189 4046-52 PubMed GONUTS page
- ↑ Wong, DK et al. (1999) Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry. Infect. Immun. 67 327-36 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
- ↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
- ↑ Målen, H et al. (2007) Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics 7 1702-18 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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