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MYCTU:F2GKE9
Contents
Species (Taxon ID) | Mycobacterium tuberculosis KZN 4207. (478433) | |
Gene Name(s) | ftsH (ECO:0000256 with HAMAP-Rule:MF_01458) | |
Protein Name(s) | ATP-dependent zinc metalloprotease FtsH (ECO:0000256 with HAMAP-Rule:MF_01458) | |
External Links | ||
UniProt | F2GKE9 | |
EMBL | CP001662 JLCP01000011 | |
RefSeq | YP_005102143.1 | |
ProteinModelPortal | F2GKE9 | |
EnsemblBacteria | AEB05804 KBM94871 | |
GeneID | 11696599 | |
KEGG | mtk:TBSG_03675 | |
KO | K03798 | |
BioCyc | MTUB478433:GH4Y-3717-MONOMER | |
Proteomes | UP000005217 | |
GO | GO:0016021 GO:0005886 GO:0005524 GO:0016887 GO:0004222 GO:0008270 GO:0030163 | |
Gene3D | 3.40.50.300 | |
HAMAP | MF_01458 | |
InterPro | IPR003593 IPR003959 IPR003960 IPR005936 IPR027417 IPR000642 | |
Pfam | PF00004 PF01434 | |
SMART | SM00382 | |
SUPFAM | SSF52540 | |
TIGRFAMs | TIGR01241 | |
PROSITE | PS00674 |
Annotations
Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
---|---|---|---|---|---|---|---|---|
GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0006979 |
response to oxidative stress |
IMP: Inferred from Mutant Phenotype |
P |
ftsH protein levels were determined when exposing Mycobacterium tuberculosis to certain oxidative stresses. One of the mutant strains, Mtb-6, which contained an overexpression of ftsH , had significantly higher percentage of cell survival versus the wild-type and antisense [Mtb-33] strains when exposed to the same oxidative stress from hydrogen peroxide [Figure 3]. This shows that the FtsH protein is required for optimal survival from exposure of agents that produce reactive oxygen intermediates. |
complete | |||
GO:0004222 |
metalloendopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
GO:0006200 |
obsolete ATP catabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
GO:0008233 |
peptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0008233 |
peptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0008237 |
metallopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0008270 |
zinc ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
GO:0016021 |
integral component of membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0016887 |
ATPase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0017111 |
nucleoside-triphosphatase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
GO:0030163 |
protein catabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
GO:0030163 |
protein catabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
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Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kiran, M et al. (2009) Mycobacterium tuberculosis ftsH expression in response to stress and viability. Tuberculosis (Edinb) 89 Suppl 1 S70-3 PubMed GONUTS page
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