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MYCLE:GYRA

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Species (Taxon ID) Mycobacterium leprae (strain TN). (272631)
Gene Name(s) gyrA (ECO:0000255 with HAMAP-Rule:MF_01897)
Protein Name(s) DNA gyrase subunit A (ECO:0000255 with HAMAP-Rule:MF_01897)

Mle gyrA intein

External Links
UniProt Q57532
EMBL Z70722
Z68206
AL583917
X87124
PIR F86909
T10006
RefSeq NP_301134.1
ProteinModelPortal Q57532
SMR Q57532
STRING 272631.ML0006
MEROPS N10.001
EnsemblBacteria CAC29514
GeneID 908154
KEGG mle:ML0006
PATRIC 18050092
Leproma ML0006
eggNOG COG1372
HOGENOM HOG000076278
KO K02469
OrthoDB EOG661H5V
Proteomes UP000000806
GO GO:0005694
GO:0005737
GO:0005524
GO:0003677
GO:0003918
GO:0004519
GO:0006265
GO:0006261
GO:0016539
Gene3D 1.10.268.10
2.170.16.10
3.10.28.10
3.30.1360.40
3.90.199.10
HAMAP MF_01897
InterPro IPR024946
IPR005743
IPR006691
IPR028992
IPR003586
IPR003587
IPR027434
IPR006142
IPR004042
IPR006141
IPR002205
IPR013758
IPR013757
IPR013760
Pfam PF03989
PF00521
PF14528
PRINTS PR00379
SMART SM00305
SM00306
SM00434
SUPFAM SSF51294
SSF55608
SSF56719
TIGRFAMs TIGR01063
TIGR01443
TIGR01445
PROSITE PS50818
PS50819
PS50817

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0034335

DNA supercoiling activity

PMID:17325221[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002205
InterPro:IPR006691
InterPro:IPR013757
InterPro:IPR013758

F

Seeded From UniProt

complete

enables

GO:0003916

DNA topoisomerase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006691

F

Seeded From UniProt

complete

enables

GO:0003918

DNA topoisomerase type II (ATP-hydrolyzing) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002205
InterPro:IPR013757
InterPro:IPR013758
InterPro:IPR013760

F

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004042
InterPro:IPR004860

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002205
InterPro:IPR006691
InterPro:IPR013757
InterPro:IPR013758
InterPro:IPR013760

F

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006691

C

Seeded From UniProt

complete

involved_in

GO:0006259

DNA metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013758

P

Seeded From UniProt

complete

involved_in

GO:0006265

DNA topological change

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002205
InterPro:IPR006691
InterPro:IPR013758

P

Seeded From UniProt

complete

involved_in

GO:0016539

intein-mediated protein splicing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006141
InterPro:IPR006142

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003916

DNA topoisomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0799

F

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Matrat, S et al. (2007) Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones. Antimicrob. Agents Chemother. 51 1643-8 PubMed GONUTS page