Category:GO:0034335 ! DNA negative supercoiling activity

name: DNA negative supercoiling activity
namespace: molecular_function
def: "Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria." [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:DNA_gyrase]
comment: Note that this term was reinstated from obsolete.
synonym: "DNA gyrase activity" RELATED []
synonym: "DNA-gyrase activity" RELATED []
is_a: GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

AmiGO <GOterm>GO:0034335</GOterm>
Gene Ontology Home